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Results for “BRAF”

551 trials

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Showing 20 of 551 results

Large-scale testing (Phase 3)Ended earlyNCT05223673
What this trial is testing

Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Institut de Recherches Internationales Servier 7
Testing effectiveness (Phase 2)Ended earlyNCT04310397
What this trial is testing

Dabrafenib, Trametinib, and Spartalizumab for the Treatment of BRAF V600E or V600K Mutation Positive Stage IIIB/C/D Melanoma

Who this might be right for
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8Pathologic Stage IIIC Cutaneous Melanoma AJCC v8Pathologic Stage IIID Cutaneous Melanoma AJCC v8
M.D. Anderson Cancer Center 4
Post-approval studies (Phase 4)Ended earlyNCT01683188
What this trial is testing

HD IL-2 + Vemurafenib in Patients With BRAF Mutation Positive Metastatic Melanoma

Who this might be right for
Metastatic Melanoma
Clinigen, Inc. 53
Testing effectiveness (Phase 2)Ended earlyNCT04488003
What this trial is testing

Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

Who this might be right for
Advanced Solid TumorBRAF Gene MutationBRAF Gene Alteration+6 more
BioMed Valley Discoveries, Inc 104
Early research (Phase 1)Ended earlyNCT04800822
What this trial is testing

PF-07284892 in Participants With Advanced Solid Tumors

Who this might be right for
Solid Tumor
Pfizer 53
Testing effectiveness (Phase 2)Active Not RecruitingNCT04722575
What this trial is testing

Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Melanoma

Who this might be right for
Melanoma
Fondazione Melanoma Onlus 95
Testing effectiveness (Phase 2)Study completedNCT02094872
What this trial is testing

Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic

Who this might be right for
Recurrent MelanomaStage IIIA MelanomaStage IIIB Melanoma+2 more
Yale University 49
Testing effectiveness (Phase 2)Looking for participantsNCT05525273
What this trial is testing

Treatment of BRAF ( B-Rapidly Accelerated Fibrosarcoma) Mutated Papillary Craniopharyngioma

Who this might be right for
Craniopharyngioma
Eva Marie Erfurth, MD, PhD 25
Early research (Phase 1)Looking for participantsNCT05985954
What this trial is testing

Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy

Who this might be right for
Metastatic Colorectal Cancer
M.D. Anderson Cancer Center 27
Early research (Phase 1)Study completedNCT03864042
What this trial is testing

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsMetastatic Melanoma
Pfizer 56
Testing effectiveness (Phase 2)Ended earlyNCT03391050
What this trial is testing

APR-246 in Combination With Dabrafenib in Resistant Patients With BRAF V600 Mutant Melanoma

Who this might be right for
Melanoma
Aprea Therapeutics 3
Testing effectiveness (Phase 2)UnknownNCT03727763
What this trial is testing

Cetuximab and Vemurafenib Plus FOLFIRI for BRAF V600E Mutated Advanced Colorectal Cancer (IMPROVEMENT)

Who this might be right for
Colorectal Cancer
Shanghai Changzheng Hospital 30
Early research (Phase 1)Study completedNCT00948467
What this trial is testing

Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies

Who this might be right for
Advanced Non-hematologic MalignanciesAdvanced Metastatic Melanoma
Millennium Pharmaceuticals, Inc. 51
Not applicableStudy completedNCT04039672
What this trial is testing

Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma

Who this might be right for
Melanoma
Hospices Civils de Lyon 10
Testing effectiveness (Phase 2)UnknownNCT05102292
What this trial is testing

The Efficacy and Safety of HLX208 in Advanced Anaplastic Thyroid Cancer (ATC) With BRAF V600 Mutation

Who this might be right for
Anaplastic Thyroid CancerATC
Shanghai Henlius Biotech 25
Testing effectiveness (Phase 2)UnknownNCT03514901
What this trial is testing

To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib.

Who this might be right for
Melanoma MetastaticBRAF V600 Mutation
Intergruppo Melanoma Italiano 120
Early research (Phase 1)Study completedNCT01738451
What this trial is testing

Evaluate the Effect of Repeat Oral Dosing of GSK2118436 on Cardiac Repolarization in Subjects With V600 BRAF Mutation-Positive Tumors

Who this might be right for
Cancer
GlaxoSmithKline 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT01709292
What this trial is testing

Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer

Who this might be right for
Thyroid Cancer
M.D. Anderson Cancer Center 24
Early research (Phase 1)Not Yet RecruitingNCT07463365
What this trial is testing

LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults

Who this might be right for
Venous Leg UlcerChronic Non-Healing Cutaneous WoundsVLU
Antoni Ribas 18
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06470880
What this trial is testing

Circulating Tumour DNA Guided Adaptive BRAF and MEK Inhibitor Therapy

Who this might be right for
Melanoma
The Christie NHS Foundation Trust 40
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