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Results for “BRAF Wildtype”

95 trials

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Showing 20 of 95 results

Testing effectiveness (Phase 2)Ended earlyNCT04375527
What this trial is testing

Binimetinib and Nivolumab for the Treatment of Locally Advanced Unresectable or Metastatic BRAF V600 Wildtype Melanoma

Who this might be right for
Clinical Stage III Cutaneous Melanoma AJCC V8Clinical Stage IV Cutaneous Melanoma AJCC V8Locally Advanced Cutaneous Melanoma+8 more
Jonsson Comprehensive Cancer Center 3
Large-scale testing (Phase 3)Looking for participantsNCT07702032
What this trial is testing

Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)

Who this might be right for
Left-sided Colorectal Cancer
Genmab 960
Large-scale testing (Phase 3)Ended earlyNCT05223673
What this trial is testing

Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Institut de Recherches Internationales Servier 7
Testing effectiveness (Phase 2)Looking for participantsNCT07012954
What this trial is testing

CtDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC

Who this might be right for
Colorectal Cancer Metastatic
Sun Yat-sen University 64
Large-scale testing (Phase 3)Looking for participantsNCT06750094
What this trial is testing

Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

Who this might be right for
Colorectal Neoplasms
Janssen Research & Development, LLC 700
Large-scale testing (Phase 3)UnknownNCT04262635
What this trial is testing

Cetuximab Plus Capecitabine as Maintenance Treatment in RAS and BRAF wt Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Sun Yat-sen University 80
Testing effectiveness (Phase 2)Study completedNCT02278133
What this trial is testing

Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway Mutations

Who this might be right for
Metastatic Colorectal Cancer
Array BioPharma 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06855849
What this trial is testing

An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients With RAS/BRAF Wild-type Advanced Colorectal Cancer Progressing on Prior Anti-EGFR Based Treatment.

Who this might be right for
RAS/BRAF Wild-type Advanced Colorectal Cancer Patients
Yonsei University 85
Testing effectiveness (Phase 2)Looking for participantsNCT05742425
What this trial is testing

Serplulimab Combined With FOLFIRI and Bevacizumab in the Treatment of Colon Cancer Peritoneal Metastases

Who this might be right for
Unresectable Colon Cancer Peritoneal MetastasesPMMR/Ras/BRAF Wild-type
Second Affiliated Hospital, Zhejiang University, School of Medicine 30
Testing effectiveness (Phase 2)Study completedNCT01941927
What this trial is testing

Trametinib With GSK2141795 in BRAF Wild-type Melanoma

Who this might be right for
Melanoma
Adil Daud 20
Testing effectiveness (Phase 2)UnknownNCT05468177
What this trial is testing

Cetuximab in Combination With Anti-PD-1 and mFOLFOX Treat For RAS/BRAF wt Right-Sided Colon Cancer

Who this might be right for
Colonic Neoplasms
Tongji Hospital 66
Testing effectiveness (Phase 2)UnknownNCT04248387
What this trial is testing

Toripalimab in the Neoadjuvant Treatment of BRAF V600 Wild Type Melanoma

Who this might be right for
Melanoma Stage IIIB-IV
Fudan University 100
Large-scale testing (Phase 3)Not Yet RecruitingNCT06959693
What this trial is testing

A Clinical Study to Evaluate the Efficacy and Safety of Envafolimab Combined With Cetuxima-βand mFOLFOX6 in Patients With MSS, RAS/BRAF Wild-Type Metastatic Colorectal Cancer (mCRC)

Who this might be right for
Metastatic Colorectal Cancer (CRC)
Sun Yat-sen University 590
Testing effectiveness (Phase 2)Active Not RecruitingNCT05312398
What this trial is testing

CAPRI 2 GOIM Study: Investigate the Efficacy and Safety of a Bio-marker Driven Cetuximab-based Treatment Regimen

Who this might be right for
Metastatic Colorectal Adenocarcinoma
University of Campania Luigi Vanvitelli 219
Not applicableStudy completedNCT04718038
What this trial is testing

Continuing Cetuximab Plus Chemotherapy After First Progression in Wild-type KRAS, NRAS and BRAF V600E Metastatic Colorectal Cancer

Who this might be right for
Wild-type KRAS,NRAS and BRAF V600E Metastatic Colorectal Cancer
Henan Cancer Hospital 60
Large-scale testing (Phase 3)Not Yet RecruitingNCT06616259
What this trial is testing

First-line Treatment of MCapOX + Cetuximab Vs. MFOLFOX6 + Cetuximab for RAS/BRAF Wild-type, MSS, Unresectable Left-Sided MCRC: a Multicenter, Randomized, Controlled, Phase III Study

Who this might be right for
Colorectal Cancer (CRC)CapecitabineCetuximab
Meng Qiu 452
Early research (Phase 1)Study completedNCT02138292
What this trial is testing

A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma

Who this might be right for
Melanoma
University of Texas Southwestern Medical Center 27
Large-scale testing (Phase 3)UnknownNCT05948072
What this trial is testing

Cetuximab+mFOLFOX6 VS. mFOLFOX6 Alone in RAS/BRAF Wild Type Patients With High-Risk Resectable CRLM

Who this might be right for
Colorectal CancerLiver Metastases
Fudan University 250
Large-scale testing (Phase 3)Looking for participantsNCT06509126
What this trial is testing

Intermittent or Continuous Panitumumab Plus FOLFIRI for Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Stage IV
National Cancer Institute, Naples 500
Testing effectiveness (Phase 2)Ended earlyNCT01605162
What this trial is testing

Phase 2 Study of the Poly(ADP-Ribose) Polymerase Inhibitor E7016 in Combination With Temozolomide in Subjects With Wild Type BRAF Stage IV or Unresectable Stage III Melanoma

Who this might be right for
Wild Type BRAF Stage IV MelanomaUnresectable Stage III Melanoma
Eisai Inc. 8
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