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Results for “BRCA 1 Gene Mutation”

78 trials

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Showing 20 of 78 results

Not applicableEnded earlyNCT04668521
What this trial is testing

Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Who this might be right for
Adnexal MassGermline BRCA1 Gene MutationGermline BRCA2 Gene Mutation+1 more
Aspira Women's Health 215
Testing effectiveness (Phase 2)Study completedNCT01009788
What this trial is testing

ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancerBRCA1 Gene Mutation+1 more
Steven J Isakoff, MD, PhD 63
Early research (Phase 1)Not Yet RecruitingNCT07088588
What this trial is testing

Study of SYN608 for the Treatment of Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid CancerMetastatic Solid TumorOvarian Cancer+3 more
Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd 105
Early research (Phase 1)Study completedNCT00892736
What this trial is testing

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Who this might be right for
Basal-Like Breast CarcinomaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+14 more
National Cancer Institute (NCI) 98
Early research (Phase 1)UnknownNCT02225015
What this trial is testing

Cancer Prevention in Women With a BRCA Mutation

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationBreast Cancer+1 more
Women's College Hospital 300
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Not applicableLooking for participantsNCT04294927
What this trial is testing

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene Mutation+3 more
University Medical Center Nijmegen 3,000
Not applicableStudy completedNCT02197000
What this trial is testing

A Nutritional Intervention to Decrease Breast Density Among Female BRCA (BReast CAncer Susceptibility Gene) Carriers

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Rabin Medical Center 23
Not applicableActive Not RecruitingNCT03546972
What this trial is testing

Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants

Who this might be right for
Deleterious BRCA1 Gene MutationDeleterious BRCA2 Gene MutationDuctal Breast Carcinoma In Situ+3 more
M.D. Anderson Cancer Center 51
Not applicableUnknownNCT01907438
What this trial is testing

Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Hadassah Medical Organization 30
Not applicableStudy completedNCT01975363
What this trial is testing

Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Gene MutationBRCA2 Gene Mutation+2 more
Ohio State University Comprehensive Cancer Center 29
Not applicableTemporarily pausedNCT02993068
What this trial is testing

Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)

Who this might be right for
BARD1 Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+12 more
M.D. Anderson Cancer Center 5,200
Testing effectiveness (Phase 2)Study completedNCT02983799
What this trial is testing

Olaparib Tablets as a Treatment for Ovarian Cancer Subjects With Different HRD Tumor Status

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 272
Not applicableStudy completedNCT00858078
What this trial is testing

A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

Who this might be right for
BRCA1 GeneBRCA2 Gene
National Cancer Institute (NCI) 76
Large-scale testing (Phase 3)Study completedNCT02000622
What this trial is testing

Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.

Who this might be right for
Breast Cancer MetastaticBRCA 1 Gene MutationBRCA 2 Gene Mutation
AstraZeneca 302
Testing effectiveness (Phase 2)UnknownNCT04556292
What this trial is testing

A Phase II Study to Assess the Efficacy and Safety of SC10914 in the Metastatic Breast Cancer Patients

Who this might be right for
Breast Cancer MetastaticBRCA 1 Gene MutationBRCA 2 Gene Mutation
Jiangxi Qingfeng Pharmaceutical Co. Ltd. 78
Early research (Phase 1)Study completedNCT01339650
What this trial is testing

Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Fallopian TubePrimary Peritoneal CancerSolid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian
AbbVie (prior sponsor, Abbott) 93
Early research (Phase 1)Study completedNCT04672460
What this trial is testing

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsSolid TumorsOvarian Cancer+5 more
Pfizer 73
Early research (Phase 1)Study completedNCT05904730
What this trial is testing

Phase I Clinical Trials Investigating the Potential Efficacy of Axitinib in Patients With a BRCA 1/2 Mutations

Who this might be right for
Breast CancerOvarian CancerBreast Neoplasms+5 more
Lynkcell Europe 10
Not applicableStudy completedNCT02963688
What this trial is testing

BRCA 1/2 Mutation in Korean Patients With Epithelial Ovarian Cancer

Who this might be right for
To Investigate the Prevalence of BRCA 1/2 Mutation Among Ovarian Cancer
Samsung Medical Center 298
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