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Results for “BRCA Mutation”

209 trials

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Showing 20 of 209 results

Not applicableStudy completedNCT05264532
What this trial is testing

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Ohio State University Comprehensive Cancer Center 58
Not applicableUnknownNCT04651933
What this trial is testing

A Training Set for the HRD Model in EOC

Who this might be right for
Epithelial Ovarian CancerBRCA MutationLoss of Heterozygosity+3 more
Lei Li 200
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Early research (Phase 1)Active Not RecruitingNCT04673448
What this trial is testing

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8BRCA-Associated Malignant Neoplasm+24 more
University of Washington 18
Testing effectiveness (Phase 2)Active Not RecruitingNCT03480776
What this trial is testing

ASA in Prevention of Ovarian Cancer (STICs and STONEs)

Who this might be right for
Ovarian Cancer Prevention
Canadian Cancer Trials Group 117
Not applicableStudy completedNCT00858078
What this trial is testing

A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

Who this might be right for
BRCA1 GeneBRCA2 Gene
National Cancer Institute (NCI) 76
Testing effectiveness (Phase 2)Study completedNCT02983799
What this trial is testing

Olaparib Tablets as a Treatment for Ovarian Cancer Subjects With Different HRD Tumor Status

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 272
Large-scale testing (Phase 3)Study completedNCT02282020
What this trial is testing

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 266
Early research (Phase 1)Study completedNCT04672460
What this trial is testing

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsSolid TumorsOvarian Cancer+5 more
Pfizer 73
Testing effectiveness (Phase 2)Looking for participantsNCT04090567
What this trial is testing

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT02393794
What this trial is testing

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Who this might be right for
Triple-Negative Breast CancerBreast Cancer
Priyanka Sharma 51
Not applicableStudy completedNCT06484725
What this trial is testing

Oncotype DX in BRCA-mutated Breast Cancer Patients: Our Experience. A Retrospective Observational Monocentric Study

Who this might be right for
Breast CancerGenetic Predisposition
IRCCS San Raffaele 250
Testing effectiveness (Phase 2)Ended earlyNCT02034916
What this trial is testing

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

Who this might be right for
Breast NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation
Pfizer 84
Not applicableStudy completedNCT05775549
What this trial is testing

Characterize the Outcomes of Olaparib Maintenance Monotherapy in Newly Diagnosed BRCAwt Ovarian Cancer

Who this might be right for
Advanced Ovarian Cancer
AstraZeneca 24
Not applicableActive Not RecruitingNCT06497270
What this trial is testing

A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial

Who this might be right for
BRCA MutationEstrogen DeficiencySurgical Menopause+3 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 3
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Testing effectiveness (Phase 2)UnknownNCT00496288
What this trial is testing

Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Who this might be right for
Breast Cancer
Assaf-Harofeh Medical Center 240
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439227
What this trial is testing

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 35
Testing effectiveness (Phase 2)Looking for participantsNCT04038502
What this trial is testing

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

Who this might be right for
Metastatic Castrate Resistant Prostate CancerBARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2RAD51B, RAD51C, RAD51D, or RAD54L Mutations
VA Office of Research and Development 100
Not applicableLooking for participantsNCT00823654
What this trial is testing

Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 609
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