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Results for “BRCA-Mutated Breast Carcinoma”

106 trials

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Showing 20 of 106 results

Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Early research (Phase 1)Active Not RecruitingNCT04673448
What this trial is testing

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8BRCA-Associated Malignant Neoplasm+24 more
University of Washington 18
Large-scale testing (Phase 3)Study completedNCT02282020
What this trial is testing

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 266
Early research (Phase 1)Study completedNCT04672460
What this trial is testing

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsSolid TumorsOvarian Cancer+5 more
Pfizer 73
Testing effectiveness (Phase 2)Looking for participantsNCT04090567
What this trial is testing

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT02393794
What this trial is testing

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Who this might be right for
Triple-Negative Breast CancerBreast Cancer
Priyanka Sharma 51
Not applicableStudy completedNCT06484725
What this trial is testing

Oncotype DX in BRCA-mutated Breast Cancer Patients: Our Experience. A Retrospective Observational Monocentric Study

Who this might be right for
Breast CancerGenetic Predisposition
IRCCS San Raffaele 250
Testing effectiveness (Phase 2)Ended earlyNCT02034916
What this trial is testing

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

Who this might be right for
Breast NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation
Pfizer 84
Not applicableStudy completedNCT05775549
What this trial is testing

Characterize the Outcomes of Olaparib Maintenance Monotherapy in Newly Diagnosed BRCAwt Ovarian Cancer

Who this might be right for
Advanced Ovarian Cancer
AstraZeneca 24
Testing effectiveness (Phase 2)UnknownNCT00496288
What this trial is testing

Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Who this might be right for
Breast Cancer
Assaf-Harofeh Medical Center 240
Early research (Phase 1)Not Yet RecruitingNCT07088588
What this trial is testing

Study of SYN608 for the Treatment of Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid CancerMetastatic Solid TumorOvarian Cancer+3 more
Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd 105
Large-scale testing (Phase 3)Active Not RecruitingNCT04915755
What this trial is testing

Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease

Who this might be right for
Neoplasms, Breast
GlaxoSmithKline 40
Early research (Phase 1)Looking for participantsNCT06666270
What this trial is testing

Study of SYN818 for the Treatment of Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid CancerMetastatic Solid TumorOvarian Cancer+4 more
Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd 30
Not applicableActive Not RecruitingNCT01608074
What this trial is testing

Radical Fimbriectomy for Young BRCA Mutation Carriers

Who this might be right for
BRCA1 MutationBRCA2 MutationHereditary Breast and Ovarian Cancer
Centre Oscar Lambret 123
Not applicableLooking for participantsNCT06817694
What this trial is testing

Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene

Who this might be right for
Breast Cancer Susceptibility Gene (BRCA1) MutationBRCA2 MutationFear of Cancer Recurrence
CHU de Quebec-Universite Laval 250
Not applicableActive Not RecruitingNCT04009148
What this trial is testing

Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome

Who this might be right for
BRCA-Mutated Ovarian CarcinomaBRIP1 Gene MutationMSH2 A636P+5 more
NYU Langone Health 118
Not applicableStudy completedNCT02151747
What this trial is testing

Testing BRCA 1/2 Mutation Using Next Generation Sequencing

Who this might be right for
Breast NeoplasmsBreast Cancer
Severance Hospital 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Large-scale testing (Phase 3)UnknownNCT03162276
What this trial is testing

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Who this might be right for
Hereditary Breast and Ovarian Cancer Syndrome
Sheba Medical Center 118
Not applicableStudy completedNCT04012229
What this trial is testing

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA)

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation
Centre Hospitalier Universitaire de Besancon 2,295
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