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Results for “BRCA1 Gene”

111 trials

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Showing 20 of 111 results

Testing effectiveness (Phase 2)Study completedNCT02598895
What this trial is testing

Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway

Who this might be right for
Castration Levels of TestosteroneCastration-Resistant Prostate CarcinomaMetastatic Prostate Carcinoma+3 more
University of Washington 14
Not applicableEnded earlyNCT04668521
What this trial is testing

Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Who this might be right for
Adnexal MassGermline BRCA1 Gene MutationGermline BRCA2 Gene Mutation+1 more
Aspira Women's Health 215
Testing effectiveness (Phase 2)Study completedNCT01009788
What this trial is testing

ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancerBRCA1 Gene Mutation+1 more
Steven J Isakoff, MD, PhD 63
Not applicableStudy completedNCT04012229
What this trial is testing

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA)

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation
Centre Hospitalier Universitaire de Besancon 2,295
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Early research (Phase 1)Not Yet RecruitingNCT06614751
What this trial is testing

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Who this might be right for
Solid CancersBRCA MutationHRD Cancer+8 more
Danatlas Pharmaceuticals Co., Ltd 112
Not applicableLooking for participantsNCT06775470
What this trial is testing

Impact of Different BRCA1/2 Gene Variants on Response to Therapy and Prognosis of Ovarian Cancer

Who this might be right for
Ovarian Cancer
IRCCS Azienda Ospedaliero-Universitaria di Bologna 300
Early research (Phase 1)UnknownNCT02225015
What this trial is testing

Cancer Prevention in Women With a BRCA Mutation

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationBreast Cancer+1 more
Women's College Hospital 300
Not applicableLooking for participantsNCT04294927
What this trial is testing

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene Mutation+3 more
University Medical Center Nijmegen 3,000
Not applicableLooking for participantsNCT03805919
What this trial is testing

Men at High Genetic Risk for Prostate Cancer

Who this might be right for
Prostatic Neoplasms
National Cancer Institute (NCI) 500
Not applicableStudy completedNCT03159572
What this trial is testing

Homologous Recombination Inquiry Through Ovarian Malignancy Investigations

Who this might be right for
Ovarian CancerFallopian Tube CancerPrimary Peritoneal Cancer
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan 996
Not applicableLooking for participantsNCT03396341
What this trial is testing

Responses to Genetic Risk Modifier Testing Among Women With Pathogenic Variants in Breast Cancer Predisposition Genes

Who this might be right for
Genetic TestingBRCA1/2
Memorial Sloan Kettering Cancer Center 806
Not applicableLooking for participantsNCT06817694
What this trial is testing

Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene

Who this might be right for
Breast Cancer Susceptibility Gene (BRCA1) MutationBRCA2 MutationFear of Cancer Recurrence
CHU de Quebec-Universite Laval 250
Not applicableStudy completedNCT02197000
What this trial is testing

A Nutritional Intervention to Decrease Breast Density Among Female BRCA (BReast CAncer Susceptibility Gene) Carriers

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Rabin Medical Center 23
Not applicableStudy completedNCT03066856
What this trial is testing

Dietary Intervention and BRCA Penetrance

Who this might be right for
Dietary ModificationBRCA1 MutationBRCA2 Mutation+1 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 502
Not applicableActive Not RecruitingNCT03546972
What this trial is testing

Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants

Who this might be right for
Deleterious BRCA1 Gene MutationDeleterious BRCA2 Gene MutationDuctal Breast Carcinoma In Situ+3 more
M.D. Anderson Cancer Center 51
Testing effectiveness (Phase 2)Ended earlyNCT03565991
What this trial is testing

Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

Who this might be right for
Locally Advanced or Metastatic Solid TumorsGenes, BRCA 1
Pfizer 202
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Not applicableUnknownNCT01907438
What this trial is testing

Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Hadassah Medical Organization 30
Not applicableStudy completedNCT01975363
What this trial is testing

Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Gene MutationBRCA2 Gene Mutation+2 more
Ohio State University Comprehensive Cancer Center 29
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