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Results for “BRCA1 Gene Mutation”

239 trials

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Showing 20 of 239 results

Not applicableStudy completedNCT05264532
What this trial is testing

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Ohio State University Comprehensive Cancer Center 58
Not applicableUnknownNCT05391763
What this trial is testing

Bilateral Prophylactic Mastectomy; Should we Preserve the Pectoral Fascia?

Who this might be right for
BRCA1/2 MutationBilateral Prophylactic MastectomySeroma+1 more
Erasmus Medical Center 21
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Testing effectiveness (Phase 2)Ended earlyNCT04718675
What this trial is testing

KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)

Who this might be right for
Relapsed Solid TumorsRefractory Solid TumorsNon-Hodgkin Lymphoma+2 more
Kronos Bio 135
Not applicableStudy completedNCT00858078
What this trial is testing

A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

Who this might be right for
BRCA1 GeneBRCA2 Gene
National Cancer Institute (NCI) 76
Not applicableStudy completedNCT04823871
What this trial is testing

Early Detection of High Grade Ovarian Cancer Using Uterine Lavage EHUD Study and Duplex Sequencing

Who this might be right for
Ovarian Epithelial CancerCarcinoma in SituOvarian Cancer
Paul Speiser, Prof.MD, 406
Testing effectiveness (Phase 2)Active Not RecruitingNCT03344965
What this trial is testing

Olaparib In Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerInvasive Breast CancerSomatic Mutation Breast Cancer (BRCA1)+7 more
Beth Israel Deaconess Medical Center 114
Not applicableStudy completedNCT04651920
What this trial is testing

A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer

Who this might be right for
Epithelial Ovarian CancerChineseHomologous Recombination Deficiency+4 more
Lei Li 240
Large-scale testing (Phase 3)Study completedNCT02282020
What this trial is testing

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 266
Not applicableLooking for participantsNCT06972719
What this trial is testing

Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy

Who this might be right for
BRCA1 MutationBRCA2 Mutation
Duke University 50
Testing effectiveness (Phase 2)Looking for participantsNCT04090567
What this trial is testing

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 60
Not applicableActive Not RecruitingNCT04499534
What this trial is testing

BRCA1/2 Flu Vaccine

Who this might be right for
BRCA1 MutationBRCA2 Mutation
Abramson Cancer Center at Penn Medicine 50
Not applicableStudy completedNCT00416754
What this trial is testing

Genetic Counseling in Women at Risk for BRCA1 or BRCA2 Mutations

Who this might be right for
Breast Cancer
Georgetown University 1,109
Testing effectiveness (Phase 2)Active Not RecruitingNCT02393794
What this trial is testing

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Who this might be right for
Triple-Negative Breast CancerBreast Cancer
Priyanka Sharma 51
Early research (Phase 1)Ended earlyNCT01233505
What this trial is testing

Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors

Who this might be right for
Adenocarcinoma of the PancreasAdenocarcinoma of the StomachBRCA1 Mutation Carrier+23 more
National Cancer Institute (NCI) 16
Testing effectiveness (Phase 2)Ended earlyNCT02034916
What this trial is testing

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

Who this might be right for
Breast NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation
Pfizer 84
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Not applicableStudy completedNCT04425200
What this trial is testing

Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting

Who this might be right for
Prostatic Neoplasms
AstraZeneca 205
Testing effectiveness (Phase 2)Study completedNCT02873975
What this trial is testing

LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

Who this might be right for
Advanced Cancers
Dana-Farber Cancer Institute 27
Not applicableLooking for participantsNCT04431024
What this trial is testing

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Who this might be right for
Familial CancerBRCA1-Associated Protein-1 (BAP1) MutationsTumor Predisposition Syndrome (TPDS)+1 more
National Cancer Institute (NCI) 800
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