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Results for “BRCA1 Mutation”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Study completedNCT01482715
What this trial is testing

Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Who this might be right for
Ovarian CancerFallopian Tube CancerPeritoneal Cancer+1 more
pharmaand GmbH 136
Not applicableLooking for participantsNCT05420064
What this trial is testing

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Who this might be right for
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer Center 1,000
Not applicableStudy completedNCT04425200
What this trial is testing

Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting

Who this might be right for
Prostatic Neoplasms
AstraZeneca 205
Large-scale testing (Phase 3)Active Not RecruitingNCT01905046
What this trial is testing

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+2 more
Alliance for Clinical Trials in Oncology 86
Early research (Phase 1)Study completedNCT00892736
What this trial is testing

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Who this might be right for
Basal-Like Breast CarcinomaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+14 more
National Cancer Institute (NCI) 98
Testing effectiveness (Phase 2)Ended earlyNCT04718675
What this trial is testing

KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)

Who this might be right for
Relapsed Solid TumorsRefractory Solid TumorsNon-Hodgkin Lymphoma+2 more
Kronos Bio 135
Testing effectiveness (Phase 2)WithdrawnNCT03432676
What this trial is testing

Epacadostat and Pembrolizumab in Treating Participants With Advanced Pancreatic Cancer

Who this might be right for
ATM Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+7 more
M.D. Anderson Cancer Center
Not applicableUnknownNCT05748353
What this trial is testing

Endocrine Disruptors and Life STILe in Breast Cancer Development

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation+3 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 275
Large-scale testing (Phase 3)Active Not RecruitingNCT04711109
What this trial is testing

Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation

Who this might be right for
BRCA1 MutationBreast CancerBreast Diseases+3 more
Alliance for Clinical Trials in Oncology 300
Early research (Phase 1)Looking for participantsNCT06458712
What this trial is testing

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Who this might be right for
Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)
Duke Street Bio Ltd 180
Not applicableLooking for participantsNCT03702309
What this trial is testing

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

Who this might be right for
CancerBreast CancerLung Cancer+15 more
University Health Network, Toronto 2,500
Testing effectiveness (Phase 2)Study completedNCT01540565
What this trial is testing

Veliparib in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierOvarian Epithelial Tumor+3 more
National Cancer Institute (NCI) 52
Large-scale testing (Phase 3)Active Not RecruitingNCT06783140
What this trial is testing

Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer

Who this might be right for
Pancreatic Cancer, Advanced or MetastaticBRCA1/2 MutationPALB2 Gene Mutation
University Health Network, Toronto 10
Testing effectiveness (Phase 2)Active Not RecruitingNCT06380660
What this trial is testing

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

Who this might be right for
Solid Tumor, AdultBRCA1 MutationBRCA2 Mutation+3 more
Acerand Therapeutics (Shanghai) Limited 298
Testing effectiveness (Phase 2)Ended earlyNCT04030559
What this trial is testing

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

Who this might be right for
ATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+14 more
University of California, Davis 11
Not applicableUnknownNCT00855998
What this trial is testing

Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer

Who this might be right for
Breast CancerOvarian Cancer
Hadassah Medical Organization 300
Testing effectiveness (Phase 2)Ended earlyNCT02034916
What this trial is testing

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

Who this might be right for
Breast NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation
Pfizer 84
Not applicableStudy completedNCT02154633
What this trial is testing

Lessons Learned From the Family Gene Toolkit

Who this might be right for
Women With BRCA 1 or BRCA 2 MutationNon-tested Female Family Members
University of Michigan 13
Early research (Phase 1)Active Not RecruitingNCT05787587
What this trial is testing

PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+6 more
IDEAYA Biosciences 216
Not applicableNot Yet RecruitingNCT07764744
What this trial is testing

Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants

Who this might be right for
Ovarian NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation+2 more
Weill Medical College of Cornell University 70
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