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Results for “BRCA1 Syndrome”

58 trials

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Showing 20 of 58 results

Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Not applicableEnded earlyNCT01103128
What this trial is testing

Validation of a Mouse Model of Pancreatic Carcinogenesis

Who this might be right for
Pancreatic Cancer
Columbia University 450
Testing effectiveness (Phase 2)Study completedNCT02797977
What this trial is testing

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Who this might be right for
Advanced Solid Tumors
Sierra Oncology LLC - a GSK company 153
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Large-scale testing (Phase 3)Study completedNCT00685256
What this trial is testing

Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children

Who this might be right for
Breast CancerHereditary Breast/Ovarian Cancer (brca1, brca2)
Georgetown University 245
Testing effectiveness (Phase 2)Study completedNCT02873975
What this trial is testing

LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

Who this might be right for
Advanced Cancers
Dana-Farber Cancer Institute 27
Not applicableLooking for participantsNCT04431024
What this trial is testing

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Who this might be right for
Familial CancerBRCA1-Associated Protein-1 (BAP1) MutationsTumor Predisposition Syndrome (TPDS)+1 more
National Cancer Institute (NCI) 800
Not applicableLooking for participantsNCT02516540
What this trial is testing

Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers

Who this might be right for
Hereditary Breast and Ovarian Cancer
Technical University of Munich 600
Not applicableStudy completedNCT03510689
What this trial is testing

Genetics and Heart Health After Cancer Therapy

Who this might be right for
Breast CancerHereditary Breast/Ovarian Cancer (brca1, Brca2)Heart Diseases+1 more
Abramson Cancer Center at Penn Medicine 79
Testing effectiveness (Phase 2)Study completedNCT00253539
What this trial is testing

Arzoxifene or Tamoxifen in Preventing Breast Cancer in Premenopausal Women at High Risk for Breast Cancer

Who this might be right for
Breast CancerHereditary Breast/Ovarian Cancer (brca1, brca2)
The Cleveland Clinic 3
Not applicableActive Not RecruitingNCT04261972
What this trial is testing

Cell-free DNA in Hereditary And High-Risk Malignancies 1

Who this might be right for
Hereditary Cancer Syndrome
University Health Network, Toronto 1,416
Not applicableActive Not RecruitingNCT01608074
What this trial is testing

Radical Fimbriectomy for Young BRCA Mutation Carriers

Who this might be right for
BRCA1 MutationBRCA2 MutationHereditary Breast and Ovarian Cancer
Centre Oscar Lambret 123
Not applicableNot Yet RecruitingNCT07236359
What this trial is testing

Evaluation of Well Being and Patient Reported Outcomes After Robotic Single-port Nipple Sparing Mastectomy and Implant Reconstruction

Who this might be right for
Breast ReconstructionBreast CancerHereditary Breast/Ovarian Cancer (brca1, brca2)+1 more
Beaumont Hospital 108
Large-scale testing (Phase 3)UnknownNCT03162276
What this trial is testing

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Who this might be right for
Hereditary Breast and Ovarian Cancer Syndrome
Sheba Medical Center 118
Not applicableUnknownNCT01273909
What this trial is testing

Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment

Who this might be right for
Breast CancerHereditary Breast/Ovarian Cancer (brca1, brca2)Acquired Lymphedema+1 more
The National Institute of Lymphology 1,000
Not applicableUnknownNCT05409222
What this trial is testing

Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT)

Who this might be right for
Hereditary Breast and Ovarian Cancer
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 45
Testing effectiveness (Phase 2)Ended earlyNCT02203513
What this trial is testing

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Who this might be right for
Ovarian CancerBreast CancerProstate Cancer
National Cancer Institute (NCI) 111
Not applicableStudy completedNCT02503436
What this trial is testing

C-PATROL - Non-interventional Study (NIS) to Collect Clinical and Patient Reported Outcome Data in an Olaparib Treated BRCAm+ PSR Ovarian Cancer Population

Who this might be right for
Ovarian Cancer, Hereditary Ovarian Cancer Syndrome
AstraZeneca 276
Not applicableStudy completedNCT00001496
What this trial is testing

Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer

Who this might be right for
Breast NeoplasmHereditary Neoplastic Syndrome
National Cancer Institute (NCI) 50
Not applicableNot Yet RecruitingNCT07436312
What this trial is testing

Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer

Who this might be right for
Breast CancerPancreas CancerColon Cancer+3 more
Gustave Roussy, Cancer Campus, Grand Paris 170
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