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Results for “BRCA2 Mutation Carrier”

43 trials

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Showing 20 of 43 results

Testing effectiveness (Phase 2)UnknownNCT00080756
What this trial is testing

Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease

Who this might be right for
brca1 Mutation Carrierbrca2 Mutation CarrierBreast Cancer
City of Hope Medical Center 11
Testing effectiveness (Phase 2)Active Not RecruitingNCT02571725
What this trial is testing

PARP-inhibition and CTLA-4 Blockade in BRCA-deficient Ovarian Cancer

Who this might be right for
Ovarian CancerFallopian Tube CancerPeritoneal Neoplasms
New Mexico Cancer Research Alliance 50
Early research (Phase 1)Study completedNCT01154426
What this trial is testing

ABT-888 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors

Who this might be right for
Adult Solid NeoplasmBRCA1 Mutation CarrierBRCA2 Mutation Carrier
National Cancer Institute (NCI) 31
Large-scale testing (Phase 3)Active Not RecruitingNCT01905046
What this trial is testing

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+2 more
Alliance for Clinical Trials in Oncology 86
Early research (Phase 1)Study completedNCT00892736
What this trial is testing

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Who this might be right for
Basal-Like Breast CarcinomaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+14 more
National Cancer Institute (NCI) 98
Testing effectiveness (Phase 2)Study completedNCT01540565
What this trial is testing

Veliparib in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierOvarian Epithelial Tumor+3 more
National Cancer Institute (NCI) 52
Not applicableStudy completedNCT03066856
What this trial is testing

Dietary Intervention and BRCA Penetrance

Who this might be right for
Dietary ModificationBRCA1 MutationBRCA2 Mutation+1 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 502
Testing effectiveness (Phase 2)Study completedNCT01506609
What this trial is testing

Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide (TMZ) or In Combination With Carboplatin and Paclitaxel Versus Placebo in Participants With Breast Cancer Gene (BRCA)1 and BRCA2 Mutation and Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
AbbVie 294
Not applicableLooking for participantsNCT02705846
What this trial is testing

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations

Who this might be right for
Prostate Cancer
Institute of Cancer Research, United Kingdom 4,260
Not applicableStudy completedNCT03684733
What this trial is testing

Magnetic Resonance Breast Tissue Characterisation to Improve Risk Stratification for Breast Cancer

Who this might be right for
BRCA1 MutationBRCA2 MutationMammography+1 more
Royal Marsden NHS Foundation Trust 28
Post-approval studies (Phase 4)Study completedNCT03495609
What this trial is testing

Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers

Who this might be right for
hCGBRCA1 MutationBRCA2 Mutation
University Hospital, Ghent 33
Early research (Phase 1)Active Not RecruitingNCT02208375
What this trial is testing

MTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierEndometrial Adenocarcinoma+13 more
M.D. Anderson Cancer Center 159
Testing effectiveness (Phase 2)Study completedNCT01009788
What this trial is testing

ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancerBRCA1 Gene Mutation+1 more
Steven J Isakoff, MD, PhD 63
Not applicableWithdrawnNCT01409226
What this trial is testing

3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation
NYU Langone Health
Early research (Phase 1)Active Not RecruitingNCT04367675
What this trial is testing

INO 5401 Vaccination in BRCA1/2 Mutation Carriers

Who this might be right for
BRCA1/2 Mutation
Abramson Cancer Center at Penn Medicine 44
Not applicableWithdrawnNCT00084370
What this trial is testing

Celecoxib in Preventing Cancer in Patients at High Risk for Ovarian Epithelial Cancer Who Are Undergoing Prophylactic Oophorectomy

Who this might be right for
brca1 Mutation Carrierbrca2 Mutation CarrierOvarian Cancer
University of Alabama at Birmingham
Testing effectiveness (Phase 2)UnknownNCT01772979
What this trial is testing

Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer

Who this might be right for
BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype
Catholic University of the Sacred Heart 100
Early research (Phase 1)Study completedNCT01339650
What this trial is testing

Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Fallopian TubePrimary Peritoneal CancerSolid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian
AbbVie (prior sponsor, Abbott) 93
Testing effectiveness (Phase 2)Study completedNCT00580112
What this trial is testing

An Efficacy Study of Trabectedin in the Treatment of Participants With Specific Subtypes of Metastatic Breast Cancer

Who this might be right for
Breast Neoplasms
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 127
Not applicableLooking for participantsNCT07253051
What this trial is testing

BRCA Mutation Carriers' Platform a Multicenter Study

Who this might be right for
BRCA1 MutationBRCA2 Mutation
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 10,000
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