Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Biologic; Inadequate”

58 trials

Showing 20 of 58 results

Large-scale testing (Phase 3)WithdrawnNCT04483687
What this trial is testing

Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy

Who this might be right for
Ankylosing Spondylitis
Gilead Sciences
Testing effectiveness (Phase 2)Study completedNCT05198310
What this trial is testing

Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor

Who this might be right for
Arthritis, Rheumatoid
Kiniksa Pharmaceuticals, Ltd. 145
Large-scale testing (Phase 3)Study completedNCT03086343
What this trial is testing

Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs

Who this might be right for
Rheumatoid Arthritis (RA)
AbbVie 657
Large-scale testing (Phase 3)Study completedNCT01254331
What this trial is testing

An Open-label Study With Tocilizumab in Patients With Rheumatoid Arthritis in a Local Environment

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 51
Large-scale testing (Phase 3)Study completedNCT00750880
What this trial is testing

An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 1,681
Post-approval studies (Phase 4)Looking for participantsNCT05552287
What this trial is testing

Pharmacokinetic Infliximab Data in Pediatric Crohn's Disease

Who this might be right for
Crohn DiseaseChild, OnlyBiologic; Inadequate
Erasmus Medical Center 50
Testing effectiveness (Phase 2)Study completedNCT00902486
What this trial is testing

INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic Drugs

Who this might be right for
Rheumatoid Arthritis
Incyte Corporation 127
Testing effectiveness (Phase 2)Study completedNCT01960855
What this trial is testing

A Study Investigating the Efficacy and Safety of ABT-494 Given With Methotrexate in Subjects With Rheumatoid Arthritis Who Failed Anti-Tumor Necrosis Factor (TNF) Biologic Therapy

Who this might be right for
Rheumatoid Arthritis
AbbVie 276
Testing effectiveness (Phase 2)Ended earlyNCT01636817
What this trial is testing

A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa Biologics

Who this might be right for
InflammationRheumatoid Arthritis
Novo Nordisk A/S 239
Large-scale testing (Phase 3)Looking for participantsNCT06332534
What this trial is testing

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

Who this might be right for
Crohn's Disease
AbbVie 110
Large-scale testing (Phase 3)Study completedNCT01835470
What this trial is testing

Efficacy, Safety, Pharmacokinetics and Immunogenicity Study of Abatacept Administered Intravenously to Treat Active Polyarticular-course Juvenile Idiopathic Arthritis in Japan

Who this might be right for
Juvenile Idiopathic Arthritis
Bristol-Myers Squibb 23
Testing effectiveness (Phase 2)Ended earlyNCT00995449
What this trial is testing

Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis

Who this might be right for
Rheumatoid Arthritis
Humanigen, Inc. 9
Large-scale testing (Phase 3)Study completedNCT00883753
What this trial is testing

An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 934
Testing effectiveness (Phase 2)WithdrawnNCT05165771
What this trial is testing

Study to Evaluate Safety, Tolerability, and Efficacy of GS-5718 in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-modifying Antirheumatic Drug(s) (bDMARDs) Treatment

Who this might be right for
Rheumatoid Arthritis
Gilead Sciences
Large-scale testing (Phase 3)Active Not RecruitingNCT05782907
What this trial is testing

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

Who this might be right for
Ulcerative Colitis
AbbVie 122
Large-scale testing (Phase 3)Study completedNCT02011334
What this trial is testing

A Study Assessing the Safety and Efficacy of Subcutaneous RoActemra/Actemra Alone or in Combination With Non-biologic Antirheumatics in Rhuematoid Arthritis Patients in Latin America With Inadequate Response to Non-biologic Antirheumatic Drugs.

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 285
Large-scale testing (Phase 3)Study completedNCT01987479
What this trial is testing

A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid Arthritis

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 150
Post-approval studies (Phase 4)WithdrawnNCT01878318
What this trial is testing

The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche
Large-scale testing (Phase 3)Study completedNCT01245439
What this trial is testing

RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis

Who this might be right for
Rheumatoid Arthritis
Hoffmann-La Roche 65
Large-scale testing (Phase 3)Study completedNCT01091675
What this trial is testing

Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs

Who this might be right for
Ankylosing Spondylitis
Spanish Foundation of Rheumatology 58
Next Page

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation