Not applicableUnknownNCT06545305What this trial is testingIncidence and Risk Factors of Ocular Complications Among Patients With HomocystinuriaWho this might be right forComplications King Fahad Armed Forces Hospital 6
Testing effectiveness (Phase 2)Looking for participantsNCT03406611What this trial is testingPegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study)Who this might be right forHomocystinuria Travere Therapeutics, Inc. 39
Not applicableUnknownNCT04578145What this trial is testingCommunity Based Screening for HIV Self Testing in FSW in 23 Priority Districts in IndonesiaWho this might be right forHuman Immunodeficiency Virus (HIV) Kerti Praja Foundation 1,522
Not applicableStudy completedNCT02998710What this trial is testingNatural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)Who this might be right forHomocystinuria Due to CBS Deficiency Travere Therapeutics, Inc. 110
Testing effectiveness (Phase 2)Ended earlyNCT05154890What this trial is testingA Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS DeficiencyWho this might be right forHomocystinuria Due to Cystathionine Beta-Synthase Deficiency Aeglea Biotherapeutics 13
Testing effectiveness (Phase 2)Temporarily pausedNCT04015557What this trial is testingEffect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on HomocystinuriaWho this might be right forCBS Deficiency Hospital de Clinicas de Porto Alegre 10
Not applicableStudy completedNCT04287881What this trial is testingMethylenetetrahydrofolate Reductase Deficiency in Ischemic StrokeWho this might be right forHyperhomocysteinemia, Thrombotic, Cbs-RelatedIschemic StrokeEpilepsy Istanbul Medeniyet University 32
Large-scale testing (Phase 3)Looking for participantsNCT06247085What this trial is testingInvestigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care TreatmentWho this might be right forHomocystinuria Travere Therapeutics, Inc. 70
Large-scale testing (Phase 3)Enrolling By InvitationNCT06431893What this trial is testingA Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)Who this might be right forHomocystinuria Travere Therapeutics, Inc. 100
Not applicableLooking for participantsNCT06556615What this trial is testingHealth Related Quality of Life (HrQoL) in Classical Homocystinuria (CBS Deficiency)Who this might be right forHomocystinuria University Children's Hospital, Zurich 80