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Results for “CDK4/6 Inhibitors”

80 trials

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Showing 20 of 80 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT06750848
What this trial is testing

Chidamide Combined With Angiogenesis Inhibitors and Fulvestrant for Advanced HR-positive, HER2-negative Breast Cancer

Who this might be right for
Advanced Breast Cancer
Jundong Wu 48
Large-scale testing (Phase 3)Looking for participantsNCT06680921
What this trial is testing

SIM0270 Combined With Everolimus vs. Treatment of Physician's Choice in Patients With ER+/HER2- Advanced Breast Cancer (SIMRISE)

Who this might be right for
Locally Advanced or Metastatic Breast Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd. 460
Not applicableLooking for participantsNCT06805812
What this trial is testing

Predicting clinicAL outcoMes During First-line CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With Advanced Hormone REceptor-poSitive HER2-negative Breast Cancer: the Retrospective-prospective Multicenter Italian PALMARES-2 Study

Who this might be right for
Breast AdenocarcinomaBreast Cancer Stage IVBreast Cancer, Metastatic+38 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 3,500
Not applicableStudy completedNCT04133207
What this trial is testing

Clinical Outcome and Toxicity Data in Patients With Advanced Breast Cancer Treated With CDK Inhibitors Combined With Endocrine Therapy

Who this might be right for
Breast Cancer Stage IV
Hellenic Cooperative Oncology Group 340
Not applicableStudy completedNCT04276272
What this trial is testing

D4 Choline Breast PET/CT

Who this might be right for
HER2-negative Breast CancerER Positive Breast CancerMetastatic Breast Cancer
Imperial College London 6
Not applicableStudy completedNCT06367335
What this trial is testing

Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer

Who this might be right for
DILI
University of Milano Bicocca 128
Not applicableLooking for participantsNCT06666439
What this trial is testing

Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer

Who this might be right for
Metastatic Invasive Lobular Carcinoma (mILC)
Julia Foldi 20
Not applicableStudy completedNCT05770713
What this trial is testing

A Real-life Study to Learn About the Use and Effects of the CDK4/6 Inhibitors in Canadian Patients With Breast Cancer.

Who this might be right for
Breast Cancer
Pfizer 48
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Not applicableStudy completedNCT07223476
What this trial is testing

Treatment Landscape and Real-World Dosing Patterns With CDK4/6 Inhibitors for Breast Cancer in Portugal

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 1,926
Large-scale testing (Phase 3)Active Not RecruitingNCT05288166
What this trial is testing

Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Who this might be right for
Prostatic NeoplasmsNeoplasm MetastasisUrogenital Neoplasms+14 more
Eli Lilly and Company 925
Testing effectiveness (Phase 2)Active Not RecruitingNCT03439735
What this trial is testing

Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC

Who this might be right for
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 45
Not applicableLooking for participantsNCT06033287
What this trial is testing

Real-World Study on CDK4/6 Inhibitors Combined With Endocrine Therapy and Subsequent Treatment in HR+/HER2- MBC.

Who this might be right for
Breast CancerEndocrine TherapyCDK4/6 Inhibitors+1 more
Hunan Cancer Hospital 300
Testing effectiveness (Phase 2)Looking for participantsNCT06207734
What this trial is testing

Discontinuation of CDK4/6 Inhibitors in Patients With Metastatic HR Positive, HER2 Negative Breast Cancer

Who this might be right for
Breast Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest 120
Not applicableStudy completedNCT04943497
What this trial is testing

A Prospective Observational Study to Describe Clinical Outcomes, Treatment Patterns, Patients Characteristics Among Patients With HR+/HER2- Advanced BC Initiating Treatment With Risarg®, Piqray®, Endocrine Therapy or Chemotherapy in Routine Clinical Practice in Russia

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 2,424
Large-scale testing (Phase 3)Looking for participantsNCT07019363
What this trial is testing

CDK4/6 Inhibitors Combined With Standard Adjuvant Endocrine Therapy in High-Risk, HR+/HER2+ Early Breast Cancer Patients(CHESS)

Who this might be right for
Breast CancerAdjuvant Therapy
Fudan University 1,903
Not applicableNot Yet RecruitingNCT07215364
What this trial is testing

Impact of Exercise on Quality of Life of EBC Patients on Treatment With Adjuvant AI With or Without CDK4/6 Inhibitors

Who this might be right for
Early-stage Breast Cancer
Spanish Breast Cancer Research Group 74
Not applicableEnrolling By InvitationNCT07100054
What this trial is testing

Pharmacogenomic and Circulating Biomarkers for CDK4/6 Inhibitors

Who this might be right for
CDK4/6 InhibitorBreast CancerCYP3A4 Protein, Human+2 more
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's 100
Large-scale testing (Phase 3)Not Yet RecruitingNCT07382687
What this trial is testing

Famitinib Combined With SHR-A1811, Versus SHR-A1811 for CDK4/6 Inhibitors-resistent Advanced HR+/HER2- Breast Cancer With SNF4 Subtype

Who this might be right for
Breast Cancer
Fudan University 248
Large-scale testing (Phase 3)Active Not RecruitingNCT06382948
What this trial is testing

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

Who this might be right for
Advanced Breast CancerER-positive Breast CancerHER2-negative Breast Cancer+1 more
MedSIR 240
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