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Results for “CDK4 Gene Amplification”

9 trials

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Showing 9 of 9 results

Very early researchEnded earlyNCT04074785
What this trial is testing

Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6

Who this might be right for
GBMGlioblastomaBrain Tumor+1 more
University of Texas Southwestern Medical Center 10
Early research (Phase 1)Looking for participantsNCT06586957
What this trial is testing

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

Who this might be right for
Solid TumorAdvanced Solid TumorSolid Tumor, Adult+25 more
NiKang Therapeutics, Inc. 150
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Large-scale testing (Phase 3)Study completedNCT02785939
What this trial is testing

Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Who this might be right for
CCND1 Gene AmplificationCCND2 Gene AmplificationCCND3 Gene Amplification+3 more
SWOG Cancer Research Network 53
Testing effectiveness (Phase 2)Looking for participantsNCT03310879
What this trial is testing

Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-Type Cyclins or Amplification of CDK4 or CDK6

Who this might be right for
Cancer
Dana-Farber Cancer Institute 38
Early research (Phase 1)Ended earlyNCT06264921
What this trial is testing

A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors

Who this might be right for
Solid TumorSolid Tumor, AdultAdvanced Solid Tumor+26 more
NiKang Therapeutics, Inc. 23
Testing effectiveness (Phase 2)Looking for participantsNCT05735080
What this trial is testing

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Who this might be right for
Breast CancerBreast Cancer MetastaticHormone Receptor Positive Tumor+6 more
Incyclix Bio 150
Early research (Phase 1)Ended earlyNCT05252416
What this trial is testing

(VELA) Study of BLU-222 in Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsHR+ Breast CancerCCNE1 Amplification+6 more
Blueprint Medicines Corporation 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT06390839
What this trial is testing

Testing Palbociclib (PD-0332991) as Potentially Targeting Treatment in Cancers With CDK4 or CDK6 Amplification (MATCH - Subprotocol Z1C)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+1 more
National Cancer Institute (NCI) 43