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Results for “Cancers With DNA Repair-Deficiency”

131 trials

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Showing 20 of 131 results

Testing effectiveness (Phase 2)Study completedNCT04740190
What this trial is testing

Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

Who this might be right for
Recurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more
The University of Hong Kong 33
Testing effectiveness (Phase 2)Active Not RecruitingNCT04266912
What this trial is testing

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

Who this might be right for
Metastatic Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
M.D. Anderson Cancer Center 23
Not applicableLooking for participantsNCT05963191
What this trial is testing

CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome

Who this might be right for
Lynch Syndrome
PERROD Guillaume 272
Not applicableLooking for participantsNCT06218433
What this trial is testing

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

Who this might be right for
Urothelial CarcinomaLynch Syndrome
Tampere University Hospital 200
Early research (Phase 1)Study completedNCT02052908
What this trial is testing

Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome

Who this might be right for
Lynch Syndrome
National Cancer Institute (NCI) 81
Not applicableNot Yet RecruitingNCT06501417
What this trial is testing

EC_ItaLynch: Mainstreaming the Diagnosis of Lynch Syndrome

Who this might be right for
Lynch SyndromeEndometrial Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 600
Testing effectiveness (Phase 2)UnknownNCT05370235
What this trial is testing

Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V

Who this might be right for
Xeroderma Pigmentosum
Clinuvel Europe Limited 6
Not applicableStudy completedNCT00406445
What this trial is testing

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Who this might be right for
Mitochondrial DisordersLi-Fraumeni SyndromeCarriers of p53 Mutation
National Heart, Lung, and Blood Institute (NHLBI) 82
Not applicableStudy completedNCT00900055
What this trial is testing

Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma

Who this might be right for
Chronic Myeloproliferative DisordersFanconi AnemiaMultiple Myeloma and Plasma Cell Neoplasm+1 more
OHSU Knight Cancer Institute 213
Early research (Phase 1)Looking for participantsNCT07163403
What this trial is testing

First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers

Who this might be right for
Lynch Syndrome
Fundacion Clinic per a la Recerca Biomédica 20
Not applicableActive Not RecruitingNCT00582296
What this trial is testing

Multi-Organ Screening Recommendations in Patients With Lynch Syndrome

Who this might be right for
Lynch Syndrome
Memorial Sloan Kettering Cancer Center 1,530
Testing effectiveness (Phase 2)UnknownNCT05461261
What this trial is testing

The Efficacy and Safety of Docetaxel Combined With Platinum for Metastatic Hormone-sensitive Prostate Cancer

Who this might be right for
Hormone Sensitive Metastatic Prostate CancerDNA Damage Repair DeficiencyChemotherapy Effect+1 more
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 50
Not applicableStudy completedNCT07838246
What this trial is testing

Liquid Biopsy Biomarkers for Endoscopic Surveillance in Lynch Syndrome

Who this might be right for
Lynch SyndromeHereditary Nonpolyposis Colorectal CancerHNPCC+2 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 109
Not applicableUnknownNCT02494791
What this trial is testing

Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer

Who this might be right for
Lynch SyndromeEndometrial NeoplasmsOvarian Neoplasms+1 more
University Health Network, Toronto 886
Early research (Phase 1)Study completedNCT03236935
What this trial is testing

Phase Ib of L-NMMA and Pembrolizumab

Who this might be right for
Non-Small Cell Lung CancerMalignant MelanomaHead and Neck Squamous Cell Carcinoma+3 more
The Methodist Hospital Research Institute 12
Testing effectiveness (Phase 2)Looking for participantsNCT03740893
What this trial is testing

PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition With or Without Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Treatment Resistant Residual Triple Negative Breast Cancer

Who this might be right for
Breast NeoplasmTriple Negative Breast Cancer (TNBC)HRD
Institute of Cancer Research, United Kingdom 119
Not applicableStudy completedNCT03344289
What this trial is testing

Linked Color Imaging Versus High-definition White Light Endoscopy for the Detection of Polyps in Patients With Lynch Syndrome (LCI-LYNCH)

Who this might be right for
Lynch SyndromeColonoscopy
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 357
Not applicableLooking for participantsNCT01793168
What this trial is testing

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Who this might be right for
Rare DisordersUndiagnosed DisordersDisorders of Unknown Prevalence+340 more
Sanford Health 20,000
Not applicableLooking for participantsNCT03303833
What this trial is testing

The GEOLynch Cohort Study

Who this might be right for
Lynch SyndromeNeoplasmsHereditary Nonpolyposis Colorectal Cancer+1 more
Wageningen University 1,000
Testing effectiveness (Phase 2)Looking for participantsNCT06088030
What this trial is testing

Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer

Who this might be right for
Pediatric CancerLi-Fraumeni Syndromep53 Mutations
Yang Li 50
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