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Results for “Cancers With DNA Repair-Deficiency”

130 trials

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Showing 20 of 130 results

Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Testing effectiveness (Phase 2)Study completedNCT04939662
What this trial is testing

Olaparib and Bevacizumab in Relapsed Small Cell Lung Cancer Subjects

Who this might be right for
Lung Cancer
Se-Hoon Lee 25
Not applicableLooking for participantsNCT06712095
What this trial is testing

Video Capsule Examination in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more
Royal Marsden NHS Foundation Trust 25
Not applicableNot Yet RecruitingNCT07689812
What this trial is testing

Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.

Who this might be right for
NSCLC (Advanced Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Carcinoma)+12 more
Natera, Inc. 920
Testing effectiveness (Phase 2)Looking for participantsNCT07262619
What this trial is testing

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Who this might be right for
Advanced Solid TumorsMSI-H or dMMR Advanced Solid TumorsMSI-H/dMMR Gastric Cancer+4 more
Eikon Therapeutics 160
Not applicableEnrolling By InvitationNCT07381985
What this trial is testing

Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment

Who this might be right for
Hereditary Cancer SyndromesBRCA1 Hereditary Breast and Ovarian Cancer SyndromeLynch Syndrome
University of Vermont Medical Center 200
Early research (Phase 1)Study completedNCT02052908
What this trial is testing

Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome

Who this might be right for
Lynch Syndrome
National Cancer Institute (NCI) 81
Not applicableStudy completedNCT00899522
What this trial is testing

Tissue Sample Collection From Patients With Fanconi Anemia

Who this might be right for
Fanconi AnemiaUnspecified Adult Solid Tumor, Protocol SpecificUnspecified Childhood Solid Tumor, Protocol Specific
OHSU Knight Cancer Institute 8
Testing effectiveness (Phase 2)Study completedNCT03476330
What this trial is testing

Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia

Who this might be right for
Fanconi AnemiaSquamous Cell Carcinoma
Children's Hospital Medical Center, Cincinnati 48
Not applicableUnknownNCT03294343
What this trial is testing

Risk-Reducing Surgeries for Hereditary Ovarian Cancer

Who this might be right for
Hereditary Breast and Ovarian Cancer SyndromeColorectal Neoplasms, Hereditary NonpolyposisOvariectomy+1 more
Lei Li 600
Not applicableUnknownNCT05909410
What this trial is testing

Perception About Benefits and Risks Related to Combined Hormonal Contraceptives Use in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeContraception
Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia 180
Testing effectiveness (Phase 2)Ended earlyNCT04276376
What this trial is testing

Efficacy and Safety of the Combination of Rucaparib (PARP Inhibitor) and Atezolizumab (Anti-PD-L1 Antibody) in Patients With DNA Repair-deficient or Platinum-sensitive Solid Tumors

Who this might be right for
Solid Tumor
Gustave Roussy, Cancer Campus, Grand Paris 130
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Testing effectiveness (Phase 2)Study completedNCT02797977
What this trial is testing

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Who this might be right for
Advanced Solid Tumors
Sierra Oncology LLC - a GSK company 153
Not applicableNot Yet RecruitingNCT07600710
What this trial is testing

Periodontal Disease in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromePeriodontal Disease
Rotundo Roberto 25
Not applicableUnknownNCT04037189
What this trial is testing

Treatment of Leukemia and Lymphoma in Children With Ataxia Telangiectasia

Who this might be right for
Ataxia TelangiectasiaLeukemiaLymphoma
Rabin Medical Center 250
Not applicableStudy completedNCT00510796
What this trial is testing

Combined Colon and Endometrial Cancer Screening in Women With HNPCC

Who this might be right for
Colon Cancer
M.D. Anderson Cancer Center 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT04266912
What this trial is testing

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

Who this might be right for
Metastatic Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
M.D. Anderson Cancer Center 23
Early research (Phase 1)Active Not RecruitingNCT02264678
What this trial is testing

Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents

Who this might be right for
Adv Solid Malig - H&N SCC, ATM Pro / Def NSCLC, Gastric, Breast and Ovarian Cancer
AstraZeneca 358
Testing effectiveness (Phase 2)Study completedNCT00305708
What this trial is testing

Busulfan, Antithymocyte Globulin, and Fludarabine Followed By a Donor Stem Cell Transplant in Treating Young Patients With Blood Disorders, Bone Marrow Disorders, Chronic Myelogenous Leukemia in First Chronic Phase, or Acute Myeloid Leukemia in First Remission

Who this might be right for
Congenital Amegakaryocytic ThrombocytopeniaDiamond-blackfan AnemiaFanconi Anemia+3 more
University of California, San Francisco 40
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