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Results for “Central Nervous System/Leptomeningeal Neoplasms”

161 trials

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Showing 20 of 161 results

Early research (Phase 1)Not Yet RecruitingNCT07702305
What this trial is testing

Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung Cancer

Who this might be right for
EGFR-TKI-resistant Non-small Cell Lung Cancer With Leptomeningeal Metastasis
Henan Cancer Hospital 15
Not applicableLooking for participantsNCT04988009
What this trial is testing

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Who this might be right for
Central Nervous System NeoplasmLeptomeningeal NeoplasmMetastatic Malignant Neoplasm in the Brain+1 more
M.D. Anderson Cancer Center 200
Early research (Phase 1)Study completedNCT00854867
What this trial is testing

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Who this might be right for
Solid Tumour Neoplastic MeningitisBrain Metastases
Mundipharma Research Limited 18
Not applicableLooking for participantsNCT06933199
What this trial is testing

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

Who this might be right for
Brain Metastases
University Hospital Ostrava 260
Early research (Phase 1)Study completedNCT00031928
What this trial is testing

Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors

Who this might be right for
Brain and Central Nervous System Tumors
National Cancer Institute (NCI) 3,000
Testing effectiveness (Phase 2)WithdrawnNCT04315246
What this trial is testing

177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)

Who this might be right for
Leptomeningeal MetastasisSolid Tumor, Adult
Y-mAbs Therapeutics
Testing effectiveness (Phase 2)Looking for participantsNCT06901817
What this trial is testing

The Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China 97
Not applicableLooking for participantsNCT06417710
What this trial is testing

Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+1 more
University of Zurich 200
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06861218
What this trial is testing

Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
Zhejiang Cancer Hospital 42
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Not applicableLooking for participantsNCT05746754
What this trial is testing

Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
University of Aarhus 50
Early research (Phase 1)Ended earlyNCT00515788
What this trial is testing

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Who this might be right for
Neoplastic Meningitis
M.D. Anderson Cancer Center 11
Post-approval studies (Phase 4)Study completedNCT00029523
What this trial is testing

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Who this might be right for
Meningeal Neoplasms
Pacira Pharmaceuticals, Inc 100
Early research (Phase 1)Study completedNCT00416923
What this trial is testing

Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma

Who this might be right for
Brain and Central Nervous System TumorsLymphoma
University of California, San Francisco 10
Not applicableWithdrawnNCT01438021
What this trial is testing

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal Metastases
City of Hope Medical Center
Not applicableLooking for participantsNCT07415018
What this trial is testing

Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease

Who this might be right for
Leptomeningeal Disease
M.D. Anderson Cancer Center 40
Early research (Phase 1)Ended earlyNCT00527410
What this trial is testing

A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis

Who this might be right for
Leptomeningeal Carcinomatosis
Biogen 9
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07751744
What this trial is testing

Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma

Who this might be right for
Brain Metastases From Solid TumorsLeptomeningeal DiseaseHigh Grade Glioma (HGG)+1 more
Jubilant Therapeutics Inc. 113
Testing effectiveness (Phase 2)Ended earlyNCT00005812
What this trial is testing

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Who this might be right for
Brain TumorsCentral Nervous System TumorsLeptomeningeal Metastases
Dartmouth-Hitchcock Medical Center 12
Not applicableStudy completedNCT02071056
What this trial is testing

Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)

Who this might be right for
Leptomeningeal Metastasis
Dartmouth-Hitchcock Medical Center 5
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