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Results for “Central Nervous System/Leptomeningeal Neoplasms”

147 trials

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Showing 20 of 147 results

Not applicableLooking for participantsNCT06643000
What this trial is testing

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal MetastasisEGFR Gene Mutation
Henan Cancer Hospital 60
Not applicableStudy completedNCT01713699
What this trial is testing

Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases

Who this might be right for
Meningeal Carcinomatosis
The Netherlands Cancer Institute 146
Early research (Phase 1)Active Not RecruitingNCT05034497
What this trial is testing

Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Plus Therapeutics 18
Not applicableLooking for participantsNCT06304441
What this trial is testing

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Who this might be right for
Leptomeningeal Metastasis
Guangzhou Medical University 100
Testing effectiveness (Phase 2)Study completedNCT02336451
What this trial is testing

A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges

Who this might be right for
ALK-positive Non-small Cell Lung Cancer
Novartis Pharmaceuticals 156
Testing effectiveness (Phase 2)Study completedNCT04420598
What this trial is testing

DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease

Who this might be right for
Advanced Breast CancerHER2-positive Breast CancerBrain Metastases+1 more
MedSIR 41
Testing effectiveness (Phase 2)Looking for participantsNCT06462092
What this trial is testing

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Who this might be right for
Leptomeningeal Metastases
Guangzhou Medical University 34
Early research (Phase 1)Looking for participantsNCT07098806
What this trial is testing

Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Plus Therapeutics 24
Early research (Phase 1)Study completedNCT00005842
What this trial is testing

Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer

Who this might be right for
Cancer
National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06441045
What this trial is testing

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Who this might be right for
Leptomeningeal Metastasis
Fujian Cancer Hospital 112
Not applicableNo Longer AvailableNCT02755987
What this trial is testing

Expanded Access to ANG1005 for Individual Patients

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligodendrogliomaBreast Cancer With Recurrent Brain Metastases+1 more
Angiochem Inc
Early research (Phase 1)Study completedNCT02423525
What this trial is testing

Safety Study of Afatinib for Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari 24
Large-scale testing (Phase 3)Ended earlyNCT03275402
What this trial is testing

131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases

Who this might be right for
NeuroblastomaCNS MetastasesLeptomeningeal Metastases
Y-mAbs Therapeutics 52
Large-scale testing (Phase 3)Study completedNCT01645839
What this trial is testing

Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer

Who this might be right for
Breast CancerLeptomeningeal Metastases
Centre Oscar Lambret 74
Testing effectiveness (Phase 2)Ended earlyNCT00005812
What this trial is testing

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Who this might be right for
Brain TumorsCentral Nervous System TumorsLeptomeningeal Metastases
Dartmouth-Hitchcock Medical Center 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT00338377
What this trial is testing

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

Who this might be right for
Melanoma
M.D. Anderson Cancer Center 1,230
Testing effectiveness (Phase 2)Active Not RecruitingNCT05865990
What this trial is testing

HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease

Who this might be right for
Metastatic Breast CancerAdvanced Non-Small Cell Squamous Lung CancerSolid Tumor, Adult
MedSIR 63
Early research (Phase 1)Study completedNCT00003462
What this trial is testing

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

Who this might be right for
Brain and Central Nervous System Tumors
Duke University 20
Testing effectiveness (Phase 2)Ended earlyNCT04729348
What this trial is testing

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

Who this might be right for
Solid TumorSolid Tumor, AdultLeptomeningeal Metastasis
Massachusetts General Hospital 10
Testing effectiveness (Phase 2)Looking for participantsNCT06809530
What this trial is testing

Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisPemetrexedPD-1 Inhibitor+2 more
Guangzhou Medical University 34
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