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Results for “Central Nervous System/Leptomeningeal Neoplasms”

149 trials

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Showing 20 of 149 results

Post-approval studies (Phase 4)UnknownNCT04356118
What this trial is testing

Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
Hui Bu 30
Testing effectiveness (Phase 2)Study completedNCT00450866
What this trial is testing

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

Who this might be right for
Breast CancerMetastatic Cancer
David Peereboom, MD 55
Not applicableNo Longer AvailableNCT05064306
What this trial is testing

131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults

Who this might be right for
Central Nervous System/Leptomeningeal Neoplasms
Memorial Sloan Kettering Cancer Center
Testing effectiveness (Phase 2)Looking for participantsNCT06762080
What this trial is testing

Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
Guangzhou Medical University 36
Early research (Phase 1)Study completedNCT03719768
What this trial is testing

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal MetastasesLeptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute 16
Early research (Phase 1)Looking for participantsNCT05184816
What this trial is testing

Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center 35
Testing effectiveness (Phase 2)Study completedNCT05146219
What this trial is testing

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

Who this might be right for
NSCLCEGFR Activating MutationBrain Metastases+1 more
TYK Medicines, Inc 29
Not applicableLooking for participantsNCT06933199
What this trial is testing

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

Who this might be right for
Brain Metastases
University Hospital Ostrava 260
Early research (Phase 1)Study completedNCT00854867
What this trial is testing

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Who this might be right for
Solid Tumour Neoplastic MeningitisBrain Metastases
Mundipharma Research Limited 18
Testing effectiveness (Phase 2)UnknownNCT05385185
What this trial is testing

Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer

Who this might be right for
Leptomeningeal MetastasisImmune Checkpoint InhibitorEndostatin
Hebei Medical University 20
Not applicableLooking for participantsNCT06643000
What this trial is testing

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal MetastasisEGFR Gene Mutation
Henan Cancer Hospital 60
Large-scale testing (Phase 3)UnknownNCT03613181
What this trial is testing

ANG1005 in Leptomeningeal Disease From Breast Cancer

Who this might be right for
Leptomeningeal CarcinomatosisLeptomeningeal MetastasesBrain Metastases+1 more
Angiochem Inc 150
Early research (Phase 1)Looking for participantsNCT03423628
What this trial is testing

Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Who this might be right for
Recurrent Glioblastoma MultiformePrimary Glioblastoma MultiformeBrain Neoplasms, Malignant+1 more
AstraZeneca 180
Testing effectiveness (Phase 2)Study completedNCT03507244
What this trial is testing

Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

Who this might be right for
Leptomeningeal Metastasis
The First Hospital of Jilin University 34
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06441045
What this trial is testing

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Who this might be right for
Leptomeningeal Metastasis
Fujian Cancer Hospital 112
Early research (Phase 1)Not Yet RecruitingNCT07390539
What this trial is testing

B7-H3.CD28Z.CART in CNS Neoplasms

Who this might be right for
Central Nervous System NeoplasmsBrain TumorBrain Tumor, Recurrent+11 more
Robbie Majzner 70
Testing effectiveness (Phase 2)Study completedNCT02939300
What this trial is testing

Ipilimumab and Nivolumab in Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Carcinomatosis
Massachusetts General Hospital 18
Testing effectiveness (Phase 2)Looking for participantsNCT06901817
What this trial is testing

The Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China 97
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Large-scale testing (Phase 3)Looking for participantsNCT06500481
What this trial is testing

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Who this might be right for
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more
NRG Oncology 115
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