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Results for “Cholestatic Genetic Diseases”

20 trials

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Enrolling by Invitation

Showing 20 of 20 results

Not applicableLooking for participantsNCT07317193
What this trial is testing

DEFINING THE GENETIC DRIVERS OF ADULT-ONSET CHOLESTATIC LIVER DISEASE

Who this might be right for
Cholestatic Liver DiseaseProgressive Familial Intrahepatic Cholestasis
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico 60
Testing effectiveness (Phase 2)Study completedNCT02047318
What this trial is testing

An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome (ALGS)

Who this might be right for
Alagille Syndrome
Mirum Pharmaceuticals, Inc. 19
Not applicableStudy completedNCT02131623
What this trial is testing

Validation of the Itch Reported Outcome (ItchRO) Diaries in Pediatric Cholestatic Liver Disease

Who this might be right for
Alagille SyndromeProgressive Familial Intrahepatic Cholestasis
Mirum Pharmaceuticals, Inc. 23
Testing effectiveness (Phase 2)UnknownNCT00004315
What this trial is testing

Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver Disease

Who this might be right for
Cystic FibrosisGastrointestinal DiseasesCholestasis
National Center for Research Resources (NCRR) 20
Not applicableStudy completedNCT01161992
What this trial is testing

Genomics of Primary Sclerosing Cholangitis (PSC)

Who this might be right for
Primary Sclerosing Cholangitis (PSC)
Mayo Clinic 1,500
Not applicableStudy completedNCT01161953
What this trial is testing

Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)

Who this might be right for
Primary Biliary Cirrhosis
Mayo Clinic 1,500
Testing effectiveness (Phase 2)Study completedNCT04729751
What this trial is testing

Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).

Who this might be right for
Progressive Familial Intrahepatic CholestasisAlagille SyndromeCholestatic Liver Disease
Mirum Pharmaceuticals, Inc. 27
Not applicableLooking for participantsNCT06767605
What this trial is testing

Spanish Registry of Autoimmune and Cholestatic Liver Diseases (ColHai)

Who this might be right for
Hepatitis Autoimmune DiseasePrimary Biliary Cholangitis (PBC)Primary Sclerosing Cholangitis (PSC)+1 more
Asociación Española para el Estudio del Hígado 5,000
Not applicableApproved For MarketingNCT04530994
What this trial is testing

A Maralixibat Expanded Access Program for Patients With Cholestatic Pruritus Associated With Alagille Syndrome (ALGS)

Who this might be right for
Alagille Syndrome
Mirum Pharmaceuticals, Inc.
Large-scale testing (Phase 3)WithdrawnNCT04531878
What this trial is testing

BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases

Who this might be right for
Hereditary DiseasesCholestasis, Intrahepatic
Children's Hospital of Fudan University
Testing effectiveness (Phase 2)Study completedNCT02057692
What this trial is testing

Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome

Who this might be right for
Alagille Syndrome
Mirum Pharmaceuticals, Inc. 37
Not applicableEnrolling By InvitationNCT06610695
What this trial is testing

PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals

Who this might be right for
CholestasisGenetic Liver Disorder
University of Aarhus 22
Early research (Phase 1)Study completedNCT02963077
What this trial is testing

A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384

Who this might be right for
Orphan Cholestatic Liver DiseasesPrimary Biliary CirrhosisProgressive Familial Intrahepatic Cholestasis+1 more
Albireo 94
Testing effectiveness (Phase 2)Study completedNCT02117713
What this trial is testing

An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Pediatric Subjects With Alagille Syndrome

Who this might be right for
Alagille Syndrome
Mirum Pharmaceuticals, Inc. 34
Early research (Phase 1)Study completedNCT03082937
What this trial is testing

An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects

Who this might be right for
Orphan Cholestatic Liver DiseasesProgressive Familial Intrahepatic CholestasisAlagille Syndrome+1 more
Albireo 6
Not applicableStudy completedNCT02922751
What this trial is testing

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Who this might be right for
Biliary AtresiaAlagille SyndromeAlpha1 Anti-Trypsin Deficiency+3 more
Arbor Research Collaborative for Health 552
Not applicableTemporarily pausedNCT00571272
What this trial is testing

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

Who this might be right for
Liver DiseasesAlagille SyndromeAlpha 1-Antitrypsin Deficiency
Arbor Research Collaborative for Health 1,675
Not applicableStudy completedNCT00007033
What this trial is testing

Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease

Who this might be right for
Alagille SyndromeCholestasisBiliary Atresia
National Center for Research Resources (NCRR) 25
Not applicableLooking for participantsNCT03131427
What this trial is testing

China Registry for Genetic / Metabolic Liver Diseases

Who this might be right for
Genetic/Metabolic Liver Diseases
Beijing Friendship Hospital 20,000
Testing effectiveness (Phase 2)Study completedNCT01903460
What this trial is testing

Safety and Efficacy Study of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Alagille Syndrome

Who this might be right for
Alagille Syndrome
Mirum Pharmaceuticals, Inc. 20