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Results for “Cyclin-Dependent Kinase 4”

57 trials

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Showing 20 of 57 results

Testing effectiveness (Phase 2)Looking for participantsNCT04750928
What this trial is testing

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Who this might be right for
Neurofibromatosis 1
National Cancer Institute (NCI) 55
Testing effectiveness (Phase 2)Study completedNCT02632045
What this trial is testing

Study of Efficacy of Ribociclib After Progression on CDK4/6 Inhibition in Patients With HR+ HER2- Advanced Breast Cancer

Who this might be right for
Metastatic Breast CancerBreast Carcinoma
Melissa K Accordino 169
Testing effectiveness (Phase 2)Active Not RecruitingNCT01723774
What this trial is testing

PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer

Who this might be right for
Breast Neoplasms
Washington University School of Medicine 84
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Not applicableUnknownNCT05051956
What this trial is testing

Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?

Who this might be right for
Can the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors
Namik Kemal University 140
Testing effectiveness (Phase 2)Study completedNCT01291017
What this trial is testing

Cyclin Dependent Kinase (CDK)4/6 Inhibitor, PD0332991 in Advanced Non-small Cell Lung Cancer NSCLC.

Who this might be right for
Non-small Cell Lung Cancer
University of Florida 19
Testing effectiveness (Phase 2)Active Not RecruitingNCT03439735
What this trial is testing

Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC

Who this might be right for
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 45
Not applicableActive Not RecruitingNCT04597580
What this trial is testing

Personalised Disease Monitoring in Metastatic Breast Cancer

Who this might be right for
Breast Cancer MetastaticEstrogen Receptor-positive Breast Cancer
The Christie NHS Foundation Trust 97
Large-scale testing (Phase 3)Study completedNCT02785939
What this trial is testing

Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Who this might be right for
CCND1 Gene AmplificationCCND2 Gene AmplificationCCND3 Gene Amplification+3 more
SWOG Cancer Research Network 53
Not applicableStudy completedNCT05361655
What this trial is testing

Real-World Effectiveness of Palbociclib in Combination With an Aromatase Inhibitor

Who this might be right for
Metastatic Breast Cancer
Pfizer 2,888
Large-scale testing (Phase 3)Ended earlyNCT04607668
What this trial is testing

Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC):

Who this might be right for
Colorectal Cancer MetastaticMyelosuppression-AdultChemotherapeutic Toxicity
G1 Therapeutics, Inc. 326
Not applicableStudy completedNCT07498413
What this trial is testing

Epidemiology and Treatment of HR+/HER2- Breast Cancer in England

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 218,677
Testing effectiveness (Phase 2)Active Not RecruitingNCT05262400
What this trial is testing

Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors

Who this might be right for
Breast CancerSolid Tumors
Pfizer 192
Testing effectiveness (Phase 2)Study completedNCT02530320
What this trial is testing

Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved

Who this might be right for
OligodendrogliomaOligoastrocytoma
Grupo Español de Investigación en Neurooncología 34
Early research (Phase 1)WithdrawnNCT05655598
What this trial is testing

TAS-116 Plus Palbociclib in Breast and Rb-null Cancer

Who this might be right for
Advanced Breast CancerTreatment-Refractory Solid TumorsRetinoblastoma Deficiency+4 more
Brown University
Not applicableStudy completedNCT06367335
What this trial is testing

Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer

Who this might be right for
DILI
University of Milano Bicocca 128
Early research (Phase 1)Study completedNCT04124653
What this trial is testing

Evaluate the Safety, Tolerability, and Pharmacokinetics of PF-06842874 in Healthy Participants

Who this might be right for
Healthy Participants
Pfizer 44
Testing effectiveness (Phase 2)Looking for participantsNCT07427394
What this trial is testing

Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer

Who this might be right for
Advanced Breast Cancer
AstraZeneca 24
Large-scale testing (Phase 3)Looking for participantsNCT06044623
What this trial is testing

Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients

Who this might be right for
Metastatic Breast CancerAdvanced Breast CancerQuality of Life+2 more
Region Örebro County 495
Not applicableStudy completedNCT06463626
What this trial is testing

Real-life Treatment Patterns With Cyclin-dependent Kinase Inhibitors in Advanced Breast Cancer in Portugal - REVEAL Study

Who this might be right for
Hormone-receptor-positive Breast CancerHuman Epidermal Growth Factor 2 Negative Carcinoma of Breast
Novartis 121
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