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Results for “Cyclin-Dependent Kinase 4”

57 trials

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Showing 20 of 57 results

Not applicableUnknownNCT05051956
What this trial is testing

Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?

Who this might be right for
Can the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors
Namik Kemal University 140
Not applicableActive Not RecruitingNCT03697577
What this trial is testing

CDK and Body Composition Study

Who this might be right for
Breast Cancer
Montefiore Medical Center 30
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06481956
What this trial is testing

T-DM1 Combined With CDK4/6 Inhibitor Ribociclib

Who this might be right for
HER2-positive Advanced Breast Cancer
Zheng Yabing 40
Early research (Phase 1)Study completedNCT05431153
What this trial is testing

Investigate the Effect of Tablet Formulation and Food on PF-07104091 in Healthy Participants

Who this might be right for
Healthy
Pfizer 30
Early research (Phase 1)WithdrawnNCT05655598
What this trial is testing

TAS-116 Plus Palbociclib in Breast and Rb-null Cancer

Who this might be right for
Advanced Breast CancerTreatment-Refractory Solid TumorsRetinoblastoma Deficiency+4 more
Brown University
Testing effectiveness (Phase 2)Study completedNCT02441946
What this trial is testing

A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer

Who this might be right for
Breast CancerHormone Receptor Positive TumorEarly-Stage Breast Carcinoma
Eli Lilly and Company 224
Not applicableStudy completedNCT06367335
What this trial is testing

Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer

Who this might be right for
DILI
University of Milano Bicocca 128
Testing effectiveness (Phase 2)Study completedNCT01684215
What this trial is testing

Oral Palbociclib (PD-0332991), A CDK4/6 Inhibitor, As Single Agent In Japanese Patients With Advanced Solid Tumors Or In Combination With Letrozole For The First-Line Treatment Of Postmenopausal Japanese Patients With ER (+) HER2 (-) Advanced Breast Cancer

Who this might be right for
NeoplasmsBreast Neoplasms
Pfizer 61
Large-scale testing (Phase 3)Study completedNCT04799249
What this trial is testing

Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC)

Who this might be right for
TNBC - Triple-Negative Breast CancerBreast Cancer
G1 Therapeutics, Inc. 194
Early research (Phase 1)Study completedNCT06267963
What this trial is testing

Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy Adults

Who this might be right for
Healthy Participants
Pfizer 12
Testing effectiveness (Phase 2)Ended earlyNCT06408168
What this trial is testing

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Who this might be right for
Hormone Receptor-positive Human Epidermal Growth Factor 2-negativeMetastatic Invasive LObular Carcinoma
M.D. Anderson Cancer Center 6
Early research (Phase 1)Ended earlyNCT01701375
What this trial is testing

Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia

Who this might be right for
Relapsed Acute LeukemiaRefractory Acute LeukemiaHigh-Risk Myelodysplasia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2
Large-scale testing (Phase 3)Looking for participantsNCT06044623
What this trial is testing

Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients

Who this might be right for
Metastatic Breast CancerAdvanced Breast CancerQuality of Life+2 more
Region Örebro County 495
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Not applicableStudy completedNCT07223476
What this trial is testing

Treatment Landscape and Real-World Dosing Patterns With CDK4/6 Inhibitors for Breast Cancer in Portugal

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 1,926
Not applicableLooking for participantsNCT06805812
What this trial is testing

Predicting clinicAL outcoMes During First-line CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With Advanced Hormone REceptor-poSitive HER2-negative Breast Cancer: the Retrospective-prospective Multicenter Italian PALMARES-2 Study

Who this might be right for
Breast AdenocarcinomaBreast Cancer Stage IVBreast Cancer, Metastatic+38 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 3,500
Not applicableStudy completedNCT04133207
What this trial is testing

Clinical Outcome and Toxicity Data in Patients With Advanced Breast Cancer Treated With CDK Inhibitors Combined With Endocrine Therapy

Who this might be right for
Breast Cancer Stage IV
Hellenic Cooperative Oncology Group 340
Early research (Phase 1)WithdrawnNCT05905341
What this trial is testing

Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.

Who this might be right for
Breast CancerOvarian CancerLiposarcoma+3 more
Pfizer
Large-scale testing (Phase 3)Study completedNCT02785939
What this trial is testing

Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Who this might be right for
CCND1 Gene AmplificationCCND2 Gene AmplificationCCND3 Gene Amplification+3 more
SWOG Cancer Research Network 53
Large-scale testing (Phase 3)Active Not RecruitingNCT05288166
What this trial is testing

Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Who this might be right for
Prostatic NeoplasmsNeoplasm MetastasisUrogenital Neoplasms+14 more
Eli Lilly and Company 925
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