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Results for “Cyclin-Dependent Kinase 6”

50 trials

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Showing 20 of 50 results

Testing effectiveness (Phase 2)Ended earlyNCT03519178
What this trial is testing

PF-06873600 in People With Cancer

Who this might be right for
HR+ HER2- Metastatic Breast Cancer, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Triple Negative Breast Cancer, Male Breast Cancer
Pfizer 155
Not applicableLooking for participantsNCT06805812
What this trial is testing

Predicting clinicAL outcoMes During First-line CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With Advanced Hormone REceptor-poSitive HER2-negative Breast Cancer: the Retrospective-prospective Multicenter Italian PALMARES-2 Study

Who this might be right for
Breast AdenocarcinomaBreast Cancer Stage IVBreast Cancer, Metastatic+38 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 3,500
Not applicableStudy completedNCT04133207
What this trial is testing

Clinical Outcome and Toxicity Data in Patients With Advanced Breast Cancer Treated With CDK Inhibitors Combined With Endocrine Therapy

Who this might be right for
Breast Cancer Stage IV
Hellenic Cooperative Oncology Group 340
Not applicableStudy completedNCT06367335
What this trial is testing

Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer

Who this might be right for
DILI
University of Milano Bicocca 128
Very early researchWithdrawnNCT04220892
What this trial is testing

Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma

Who this might be right for
High Grade Glioma
Jose Carrillo
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Not applicableStudy completedNCT07223476
What this trial is testing

Treatment Landscape and Real-World Dosing Patterns With CDK4/6 Inhibitors for Breast Cancer in Portugal

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 1,926
Large-scale testing (Phase 3)Active Not RecruitingNCT05288166
What this trial is testing

Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Who this might be right for
Prostatic NeoplasmsNeoplasm MetastasisUrogenital Neoplasms+14 more
Eli Lilly and Company 925
Testing effectiveness (Phase 2)Active Not RecruitingNCT03439735
What this trial is testing

Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC

Who this might be right for
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 45
Not applicableApproved For MarketingNCT04504513
What this trial is testing

Expanded Access to Trilaciclib for Patients Receiving Chemotherapy for Small Cell Lung Cancer

Who this might be right for
Myelosuppression AdultChemotherapeutic ToxicitySmall Cell Lung Cancer
G1 Therapeutics, Inc.
Not applicableStudy completedNCT06463626
What this trial is testing

Real-life Treatment Patterns With Cyclin-dependent Kinase Inhibitors in Advanced Breast Cancer in Portugal - REVEAL Study

Who this might be right for
Hormone-receptor-positive Breast CancerHuman Epidermal Growth Factor 2 Negative Carcinoma of Breast
Novartis 121
Large-scale testing (Phase 3)Looking for participantsNCT06044623
What this trial is testing

Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients

Who this might be right for
Metastatic Breast CancerAdvanced Breast CancerQuality of Life+2 more
Region Örebro County 495
Testing effectiveness (Phase 2)Ended earlyNCT06408168
What this trial is testing

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Who this might be right for
Hormone Receptor-positive Human Epidermal Growth Factor 2-negativeMetastatic Invasive LObular Carcinoma
M.D. Anderson Cancer Center 6
Testing effectiveness (Phase 2)Ended earlyNCT04887831
What this trial is testing

Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab

Who this might be right for
Urothelial CarcinomaBladder CancerMyelosuppression Adult+2 more
G1 Therapeutics, Inc. 92
Early research (Phase 1)Study completedNCT05538572
What this trial is testing

PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors

Who this might be right for
Breast CancerGlioblastomaHead and Neck Squamous Cell Carcinoma+4 more
Prelude Therapeutics 22
Testing effectiveness (Phase 2)Study completedNCT02632045
What this trial is testing

Study of Efficacy of Ribociclib After Progression on CDK4/6 Inhibition in Patients With HR+ HER2- Advanced Breast Cancer

Who this might be right for
Metastatic Breast CancerBreast Carcinoma
Melissa K Accordino 169
Testing effectiveness (Phase 2)Study completedNCT03227328
What this trial is testing

CDK4/6-inhibitor or Chemotherapy, in Combination with ENDOcrine Therapy, for Advanced Breast Cancer / KENDO

Who this might be right for
Hormone Receptor Positive Breast CancerMetastatic Breast CancerHormone Receptor Negative Breast Cancer
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS 52
Not applicableUnknownNCT05051956
What this trial is testing

Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?

Who this might be right for
Can the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors
Namik Kemal University 140
Not applicableActive Not RecruitingNCT04597580
What this trial is testing

Personalised Disease Monitoring in Metastatic Breast Cancer

Who this might be right for
Breast Cancer MetastaticEstrogen Receptor-positive Breast Cancer
The Christie NHS Foundation Trust 97
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06849947
What this trial is testing

Fulvestrant With Ribociclib Versus Physician's Choice Treatments Recurred After Completion of Adjuvant Cyclin-Dependent Kinase 4/6 Inhibitors in HR+, HER2- Metastatic Breast Cancer

Who this might be right for
Breast Cancer Metastatic
Yeon Hee Park 272
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