Very early researchWithdrawnNCT04220892What this trial is testingPilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade GliomaWho this might be right forHigh Grade Glioma Jose Carrillo
Not applicableStudy completedNCT04133207What this trial is testingClinical Outcome and Toxicity Data in Patients With Advanced Breast Cancer Treated With CDK Inhibitors Combined With Endocrine TherapyWho this might be right forBreast Cancer Stage IV Hellenic Cooperative Oncology Group 340
Large-scale testing (Phase 3)Not Yet RecruitingNCT06996093What this trial is testingChemotherapy Omission in HR-positive/HER2-negative Breast Cancer With Lymph Node Negative Disease Receiving Adjuvant Endocrine Therapy and CDK4/6 InhibitorWho this might be right forBreast Cancer Fudan University 2,508
Testing effectiveness (Phase 2)Active Not RecruitingNCT01723774What this trial is testingPD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast CancerWho this might be right forBreast Neoplasms Washington University School of Medicine 84
Early research (Phase 1)Study completedNCT02499146What this trial is testingPalbociclib Pharmacokinetics Study In Postmenopausal Chinese Women With ER (+), HER2 (-) Advanced Breast CancerWho this might be right forAdvanced Breast Cancer Pfizer 26
Testing effectiveness (Phase 2)Ended earlyNCT04863248What this trial is testingTrilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Docetaxel for Metastatic Non-Small Cell Lung Cancer (NSCLC) (PRESERVE 4)Who this might be right forMetastatic Non-Small Cell Lung CancerNSCLCLung Cancer G1 Therapeutics, Inc. 10
Large-scale testing (Phase 3)Study completedNCT04799249What this trial is testingTrilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC)Who this might be right forTNBC - Triple-Negative Breast CancerBreast Cancer G1 Therapeutics, Inc. 194
Large-scale testing (Phase 3)Looking for participantsNCT06044623What this trial is testingImplementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer PatientsWho this might be right forMetastatic Breast CancerAdvanced Breast CancerQuality of Life+2 more Region Örebro County 495
Testing effectiveness (Phase 2)Study completedNCT02441946What this trial is testingA Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast CancerWho this might be right forBreast CancerHormone Receptor Positive TumorEarly-Stage Breast Carcinoma Eli Lilly and Company 224
Not applicableUnknownNCT05051956What this trial is testingEvaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast Cancer Patients?Who this might be right forCan the Geriatric Questionnaires Predict Adverse Effects in Geriatric Breast Cancer Patients Treated With Cyclin-dependent Kinase 4 and 6 Inhibitors Namik Kemal University 140
Not applicableStudy completedNCT07498413What this trial is testingEpidemiology and Treatment of HR+/HER2- Breast Cancer in EnglandWho this might be right forBreast Cancer Novartis Pharmaceuticals 218,677
Testing effectiveness (Phase 2)Study completedNCT02530320What this trial is testingSafety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB PreservedWho this might be right forOligodendrogliomaOligoastrocytoma Grupo Español de Investigación en Neurooncología 34
Not applicableStudy completedNCT06367335What this trial is testingCharacteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast CancerWho this might be right forDILI University of Milano Bicocca 128
Large-scale testing (Phase 3)Not Yet RecruitingNCT05249556What this trial is testingDouble-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Years OldWho this might be right forCDKL5 Deficiency Disorder Immedica Pharma AB 20
Early research (Phase 1)Study completedNCT04124653What this trial is testingEvaluate the Safety, Tolerability, and Pharmacokinetics of PF-06842874 in Healthy ParticipantsWho this might be right forHealthy Participants Pfizer 44
Testing effectiveness (Phase 2)Looking for participantsNCT06947811What this trial is testingAlmonertinib Combined With Palbociclib in Patients With Advanced Solid Tumors Harboring KRAS MutationsWho this might be right forEGFR Tyrosine Kinase Inhibitors Plus Cyclin-dependent Kinase 4/6 Inhibitor Sun Yat-sen University 71
Testing effectiveness (Phase 2)Looking for participantsNCT04469764What this trial is testingAbemaciclib for the Treatment of Recurrent Ovarian or Endometrial CancerWho this might be right forRecurrent Endometrial CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Ovarian Carcinoma+1 more Jonsson Comprehensive Cancer Center 32
Testing effectiveness (Phase 2)Study completedNCT01291017What this trial is testingCyclin Dependent Kinase (CDK)4/6 Inhibitor, PD0332991 in Advanced Non-small Cell Lung Cancer NSCLC.Who this might be right forNon-small Cell Lung Cancer University of Florida 19
Early research (Phase 1)Ended earlyNCT01701375What this trial is testingTrial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk MyelodysplasiaWho this might be right forRelapsed Acute LeukemiaRefractory Acute LeukemiaHigh-Risk Myelodysplasia Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2
Early research (Phase 1)WithdrawnNCT04585724What this trial is testingStereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain MetastasesWho this might be right forAnatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more Emory University