Large-scale testing (Phase 3)Active Not RecruitingNCT04821622What this trial is testingStudy of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPCWho this might be right forProstate Cancer Pfizer 599
Testing effectiveness (Phase 2)Looking for participantsNCT05222971What this trial is testingOlaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based ChemotherapyWho this might be right forBiliary Tract CancerDNA Damage Repair Deficiency Asan Medical Center 62
Early research (Phase 1)Not Yet RecruitingNCT06614751What this trial is testingA PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR PathwayWho this might be right forSolid CancersBRCA MutationHRD Cancer+8 more Danatlas Pharmaceuticals Co., Ltd 112
Testing effectiveness (Phase 2)UnknownNCT04761744What this trial is testingA Phase II Study of Nivolumab in Patients With Genetic Alterations in DNA Damage Repair and Response Who Progressed After Standard Treatment for Metastatic Solid CancersWho this might be right forDDR Gene MutationMetastatic Solid Tumor Korean Cancer Study Group 48
Testing effectiveness (Phase 2)Looking for participantsNCT05933265What this trial is testingStudy of LP-184 in Patients With Advanced Solid TumorsWho this might be right forAdvanced Solid TumorMetastatic Solid TumorGBM+4 more Lantern Pharma Inc. 175
Testing effectiveness (Phase 2)Active Not RecruitingNCT04030559What this trial is testingNiraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response DefectsWho this might be right forATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+14 more Marc Dall'Era, MD 11