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Results for “DNA Repair Gene Mutation”

69 trials

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Showing 20 of 69 results

Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Testing effectiveness (Phase 2)Active Not RecruitingNCT03344965
What this trial is testing

Olaparib In Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerInvasive Breast CancerSomatic Mutation Breast Cancer (BRCA1)+7 more
Beth Israel Deaconess Medical Center 114
Not applicableUnknownNCT03294343
What this trial is testing

Risk-Reducing Surgeries for Hereditary Ovarian Cancer

Who this might be right for
Hereditary Breast and Ovarian Cancer SyndromeColorectal Neoplasms, Hereditary NonpolyposisOvariectomy+1 more
Lei Li 600
Not applicableLooking for participantsNCT03830229
What this trial is testing

Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

Who this might be right for
MesotheliomaFamilies
National Cancer Institute (NCI) 1,000
Testing effectiveness (Phase 2)UnknownNCT04042831
What this trial is testing

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Who this might be right for
Bile Duct AdenocarcinomaFanconi Anemia Complementation Group Gene MutationMetastatic Bile Duct Carcinoma+1 more
Academic and Community Cancer Research United 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT05203445
What this trial is testing

Olaparib and Pembrolizumab in People With Triple Negative Breast Cancer (TNBC) or Hormone Receptor-positive HER2-negative Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 23
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Testing effectiveness (Phase 2)Study completedNCT02873975
What this trial is testing

LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

Who this might be right for
Advanced Cancers
Dana-Farber Cancer Institute 27
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Not applicableLooking for participantsNCT07472686
What this trial is testing

Small Bowel Capsule Endoscopy in Lynch Syndrome

Who this might be right for
MMR MutationSmall Bowel AdenomaSmall-bowel Adenocarcinoma+2 more
Assistance Publique - Hôpitaux de Paris 400
Testing effectiveness (Phase 2)UnknownNCT05461261
What this trial is testing

The Efficacy and Safety of Docetaxel Combined With Platinum for Metastatic Hormone-sensitive Prostate Cancer

Who this might be right for
Hormone Sensitive Metastatic Prostate CancerDNA Damage Repair DeficiencyChemotherapy Effect+1 more
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 50
Testing effectiveness (Phase 2)Study completedNCT03962114
What this trial is testing

Effects of Vitamin B3 in Patients With Ataxia Telangiectasia

Who this might be right for
Ataxia TelangiectasiaATM Gene Mutation
Radboud University Medical Center 24
Testing effectiveness (Phase 2)Ended earlyNCT03631641
What this trial is testing

Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy

Who this might be right for
Colon AdenomaColon CarcinomaLynch Syndrome+2 more
John Hays 3
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Large-scale testing (Phase 3)Active Not RecruitingNCT04821622
What this trial is testing

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC

Who this might be right for
Prostate Cancer
Pfizer 599
Not applicableUnknownNCT03495544
What this trial is testing

Study Estimating Association Between Germline Mutations and PD-L1 Expression in Breast Cancer

Who this might be right for
Hereditary Breast Cancer
Tatarstan Cancer Center 390
Testing effectiveness (Phase 2)Ended earlyNCT02203513
What this trial is testing

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Who this might be right for
Ovarian CancerBreast CancerProstate Cancer
National Cancer Institute (NCI) 111
Testing effectiveness (Phase 2)Looking for participantsNCT05222971
What this trial is testing

Olaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based Chemotherapy

Who this might be right for
Biliary Tract CancerDNA Damage Repair Deficiency
Asan Medical Center 62
Not applicableStudy completedNCT00353639
What this trial is testing

Telomere Repair Gene Mutation in Inflammatory Bowel Disease

Who this might be right for
Inflammatory Bowel Disease
National Heart, Lung, and Blood Institute (NHLBI) 95
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