Large-scale testing (Phase 3)Active Not RecruitingNCT04821622What this trial is testingStudy of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPCWho this might be right forProstate Cancer Pfizer 599
Not applicableStudy completedNCT02699190What this trial is testingLeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for LeukodystrophiesWho this might be right forLeukodystrophyWhite Matter Disease4H Syndrome+61 more Children's Hospital of Philadelphia 236
Not applicableActive Not RecruitingNCT02194387What this trial is testingEnergy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family MembersWho this might be right forBody Mass Index 25 or GreaterBRCA1 Gene MutationBRCA2 Gene Mutation+8 more M.D. Anderson Cancer Center 337
Not applicableStudy completedNCT06490510What this trial is testingPrognostic Significance of Mutation Type and Chromosome Fragility in Fanconi AnemiaWho this might be right forFanconi Anemia Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 227
Not applicableStudy completedNCT05573789What this trial is testingTumor Molecular Profiling in Patients With Prostate CancerWho this might be right forProstate CancerMetastatic Prostate Adenocarcinoma Hellenic Cooperative Oncology Group 220
Not applicableLooking for participantsNCT05129605What this trial is testingProstate Cancer Genetic Risk Evaluation and Screening StudyWho this might be right forProstatic NeoplasmProstate CancerBRCA2 Mutation+5 more Massachusetts General Hospital 400
Testing effectiveness (Phase 2)Looking for participantsNCT05222971What this trial is testingOlaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based ChemotherapyWho this might be right forBiliary Tract CancerDNA Damage Repair Deficiency Asan Medical Center 62
Testing effectiveness (Phase 2)Study completedNCT04740190What this trial is testingTalazoparib - Carboplatin for Recurrent High-grade Glioma With DDRdWho this might be right forRecurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more The University of Hong Kong 33
Not applicableStudy completedNCT03889171What this trial is testingComparison to Psychological, Medical and Emotional Influencing Communication and Achievement Factors to Oncogenetics TestsWho this might be right forCancerColorectal CancerBreast Cancer+1 more University Hospital, Montpellier 200
Not applicableLooking for participantsNCT07220239What this trial is testingMenstrual Cup for Early Endometrial Cancer Detection in Lynch SyndromeWho this might be right forEndometrial CancerLynch SyndromeScreening+1 more Jessica D. St. Laurent, MD 25
Early research (Phase 1)Not Yet RecruitingNCT06614751What this trial is testingA PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR PathwayWho this might be right forSolid CancersBRCA MutationHRD Cancer+8 more Danatlas Pharmaceuticals Co., Ltd 112
Not applicableUnknownNCT03294343What this trial is testingRisk-Reducing Surgeries for Hereditary Ovarian CancerWho this might be right forHereditary Breast and Ovarian Cancer SyndromeColorectal Neoplasms, Hereditary NonpolyposisOvariectomy+1 more Lei Li 600
Testing effectiveness (Phase 2)UnknownNCT04761744What this trial is testingA Phase II Study of Nivolumab in Patients With Genetic Alterations in DNA Damage Repair and Response Who Progressed After Standard Treatment for Metastatic Solid CancersWho this might be right forDDR Gene MutationMetastatic Solid Tumor Korean Cancer Study Group 48
Not applicableLooking for participantsNCT02775461What this trial is testingPancreas Registry and High Risk RegistryWho this might be right forPancreas CancerPancreatitisChronic Pancreatitis+3 more Icahn School of Medicine at Mount Sinai 1,368
Not applicableWithdrawnNCT02309632What this trial is testingPancreatic Cancer Screening of High-Risk Individuals in ArkansasWho this might be right forPancreatic NeoplasmsPeutz-Jegher's SyndromeBRCA1 Gene Mutation+5 more University of Arkansas
Testing effectiveness (Phase 2)Active Not RecruitingNCT05203445What this trial is testingOlaparib and Pembrolizumab in People With Triple Negative Breast Cancer (TNBC) or Hormone Receptor-positive HER2-negative Breast CancerWho this might be right forBreast Cancer Memorial Sloan Kettering Cancer Center 23
Testing effectiveness (Phase 2)Ended earlyNCT03442556What this trial is testingDocetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair DeficiencyWho this might be right forATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+7 more University of Washington 18
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07215416What this trial is testingSafety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)Who this might be right forAtaxia Telangiectasia Timothy Yu 10
Not applicableActive Not RecruitingNCT00261456What this trial is testingThe IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte CancerWho this might be right forProstate CancerBRCA MutationMismatch Repair Gene Mutation+1 more Institute of Cancer Research, United Kingdom 3,500
Testing effectiveness (Phase 2)Study completedNCT03413995What this trial is testingTrial of Rucaparib in Patients With Metastatic Hormone-Sensitive Prostate Cancer Harboring Germline DNA Repair Gene MutationsWho this might be right forProstate Cancer Metastatic Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 12