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Results for “DNA Repair Gene Mutation”

69 trials

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Showing 20 of 69 results

Not applicableLooking for participantsNCT05378204
What this trial is testing

Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer.

Who this might be right for
Breast Cancer
Institut Claudius Regaud 120
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Testing effectiveness (Phase 2)Study completedNCT04740190
What this trial is testing

Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

Who this might be right for
Recurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more
The University of Hong Kong 33
Testing effectiveness (Phase 2)UnknownNCT04761744
What this trial is testing

A Phase II Study of Nivolumab in Patients With Genetic Alterations in DNA Damage Repair and Response Who Progressed After Standard Treatment for Metastatic Solid Cancers

Who this might be right for
DDR Gene MutationMetastatic Solid Tumor
Korean Cancer Study Group 48
Not applicableLooking for participantsNCT07498829
What this trial is testing

Population Based Germline Testing for Early Detection and Prevention of Cancer

Who this might be right for
Breast Cancer RiskOvarian Cancer RiskCancer Gene Mutation
Queen Mary University of London 6,000
Early research (Phase 1)Study completedNCT03318445
What this trial is testing

Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair

Who this might be right for
Solid Tumor, Unspecified, Adult
Pamela Munster 22
Not applicableLooking for participantsNCT03124212
What this trial is testing

Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland

Who this might be right for
Hereditary Breast and Ovarian CancerLynch Syndrome
University of Basel 700
Not applicableLooking for participantsNCT03702309
What this trial is testing

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

Who this might be right for
CancerBreast CancerLung Cancer+15 more
University Health Network, Toronto 2,500
Testing effectiveness (Phase 2)Ended earlyNCT04030559
What this trial is testing

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

Who this might be right for
ATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+14 more
University of California, Davis 11
Not applicableUnknownNCT06163365
What this trial is testing

Inherited Cancer Early Diagnosis (ICED) Study

Who this might be right for
Li Fraumeni SyndromeLynch SyndromeHereditary Diffuse Gastric Cancer+5 more
Royal Marsden NHS Foundation Trust 100
Early research (Phase 1)Looking for participantsNCT05694715
What this trial is testing

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Who this might be right for
Metastatic Solid TumorBRCA1 MutationBRCA2 Mutation+2 more
University of California, San Francisco 24
Not applicableStudy completedNCT02289326
What this trial is testing

Biomarker Monitoring in TP53 Mutation Carriers

Who this might be right for
Li-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier
Scripps Health 6
Not applicableLooking for participantsNCT07472686
What this trial is testing

Small Bowel Capsule Endoscopy in Lynch Syndrome

Who this might be right for
MMR MutationSmall Bowel AdenomaSmall-bowel Adenocarcinoma+2 more
Assistance Publique - Hôpitaux de Paris 400
Not applicableStudy completedNCT06490510
What this trial is testing

Prognostic Significance of Mutation Type and Chromosome Fragility in Fanconi Anemia

Who this might be right for
Fanconi Anemia
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 227
Early research (Phase 1)Not Yet RecruitingNCT06614751
What this trial is testing

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Who this might be right for
Solid CancersBRCA MutationHRD Cancer+8 more
Danatlas Pharmaceuticals Co., Ltd 112
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Not applicableLooking for participantsNCT02705846
What this trial is testing

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations

Who this might be right for
Prostate Cancer
Institute of Cancer Research, United Kingdom 4,260
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Testing effectiveness (Phase 2)Ended earlyNCT03442556
What this trial is testing

Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

Who this might be right for
ATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+7 more
University of Washington 18
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