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Results for “DNA Repair Gene Mutation”

69 trials

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Showing 20 of 69 results

Not applicableLooking for participantsNCT07450612
What this trial is testing

Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

Who this might be right for
Colorectal CancerAdenoma ColonAdenoma Colon Polyp+16 more
San Raffaele University 1,200
Not applicableLooking for participantsNCT07498829
What this trial is testing

Population Based Germline Testing for Early Detection and Prevention of Cancer

Who this might be right for
Breast Cancer RiskOvarian Cancer RiskCancer Gene Mutation
Queen Mary University of London 6,000
Testing effectiveness (Phase 2)Ended earlyNCT02203513
What this trial is testing

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Who this might be right for
Ovarian CancerBreast CancerProstate Cancer
National Cancer Institute (NCI) 111
Not applicableLooking for participantsNCT03702309
What this trial is testing

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

Who this might be right for
CancerBreast CancerLung Cancer+15 more
University Health Network, Toronto 2,500
Not applicableLooking for participantsNCT03124212
What this trial is testing

Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland

Who this might be right for
Hereditary Breast and Ovarian CancerLynch Syndrome
University of Basel 700
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Early research (Phase 1)Not Yet RecruitingNCT06614751
What this trial is testing

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Who this might be right for
Solid CancersBRCA MutationHRD Cancer+8 more
Danatlas Pharmaceuticals Co., Ltd 112
Testing effectiveness (Phase 2)Study completedNCT03962114
What this trial is testing

Effects of Vitamin B3 in Patients With Ataxia Telangiectasia

Who this might be right for
Ataxia TelangiectasiaATM Gene Mutation
Radboud University Medical Center 24
Not applicableLooking for participantsNCT06712095
What this trial is testing

Video Capsule Examination in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more
Royal Marsden NHS Foundation Trust 25
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Not applicableActive Not RecruitingNCT05692596
What this trial is testing

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Who this might be right for
Pancreatic Ductal AdenocarcinomaPancreatic CystChronic Pancreatitis+10 more
H. Lee Moffitt Cancer Center and Research Institute 317
Testing effectiveness (Phase 2)Looking for participantsNCT07215416
What this trial is testing

Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)

Who this might be right for
Ataxia Telangiectasia
Timothy Yu 10
Not applicableLooking for participantsNCT03830229
What this trial is testing

Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1

Who this might be right for
MesotheliomaFamilies
National Cancer Institute (NCI) 1,000
Early research (Phase 1)UnknownNCT02950064
What this trial is testing

Determine the Safety of BTP-114 for Treatment in Patients With Advanced Solid Tumors With BRCA Mutations

Who this might be right for
Pancreatic NeoplasmsOvarian NeoplasmsBreast Neoplasms+1 more
Placon Therapeutics 95
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Not applicableStudy completedNCT02699190
What this trial is testing

LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies

Who this might be right for
LeukodystrophyWhite Matter Disease4H Syndrome+61 more
Children's Hospital of Philadelphia 236
Large-scale testing (Phase 3)Active Not RecruitingNCT04821622
What this trial is testing

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC

Who this might be right for
Prostate Cancer
Pfizer 599
Testing effectiveness (Phase 2)Looking for participantsNCT05071222
What this trial is testing

Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Artemis (DCLRE1C) Deficient Severe Combined Immunodeficiency Patients (ARTEGENE)

Who this might be right for
Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency
Assistance Publique - Hôpitaux de Paris 7
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