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Results for “De Novo Mutation”

13 trials

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Showing 13 of 13 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07750574
What this trial is testing

Flonoltinib Maleate Oral Regimens in Patients With Myelofibrosis

Who this might be right for
MyelofibrosisMyelofibrosis Due to and Following Polycythemia VeraMyelofibrosis Transformation in Essential Thrombocythemia+9 more
Chengdu Zenitar Biomedical Technology Co., Ltd 105
Not applicableUnknownNCT03589079
What this trial is testing

Delineation of Novel Monogenic Disorders in the United Arab Emirates Population

Who this might be right for
Mendelian DisordersGenetic DisorderNovel Mutation+4 more
Imperial College London Diabetes Centre 150
Not applicableUnknownNCT01697163
What this trial is testing

De Novo Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors

Who this might be right for
NSCLC
Severance Hospital 155
Not applicableStudy completedNCT05149469
What this trial is testing

Molecular Aspects of Preimplantation Genetic Diagnosis for NF1

Who this might be right for
Neurofibromatosis Type 1
University Hospital, Strasbourg, France 60
Early research (Phase 1)Active Not RecruitingNCT02632708
What this trial is testing

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Who this might be right for
Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)+2 more
Institut de Recherches Internationales Servier 153
Not applicableStudy completedNCT04564235
What this trial is testing

Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools

Who this might be right for
Developmental Disorders
University Hospital, Rouen 5
Testing effectiveness (Phase 2)Study completedNCT02108964
What this trial is testing

A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies

Who this might be right for
Advanced Non-small Cell Lung Cancer
Novartis Pharmaceuticals 225
Early research (Phase 1)Study completedNCT00003959
What this trial is testing

Vaccine Therapy in Treating Patients With Myelodysplastic Syndrome

Who this might be right for
LeukemiaMyelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center 1
Large-scale testing (Phase 3)Looking for participantsNCT04293562
What this trial is testing

Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Who this might be right for
Acute Myeloid Leukemia
Children's Oncology Group 1,400
Not applicableEnrolling By InvitationNCT06722313
What this trial is testing

Optimized PGT-M Strategy for Patients With No Proband

Who this might be right for
De Novo MutationPreimplantation Genetic TestingWithout Proband
ShangHai Ji Ai Genetics & IVF Institute 5
Not applicableUnknownNCT05739890
What this trial is testing

Whole Genome Sequencing (WGS) on IVF Embryos and Individual Patients

Who this might be right for
Fertility IssuesSingle-Gene Defects
GenEmbryomics Pty. Ltd 100
Large-scale testing (Phase 3)Not Yet RecruitingNCT07591467
What this trial is testing

Carboplatin-Enhanced Therapy in BRCA-Mutated or Neuroendocrine-Differentiated Aggressive Metastatic Castration-Sensitive Prostate Cancer

Who this might be right for
BRCA-MutatedNeuroendocrine-Differentiated Aggressive Metastatic Castration-Sensitive Prostate CancerProstate Cancer
Gustave Roussy, Cancer Campus, Grand Paris 330
Testing effectiveness (Phase 2)Study completedNCT01904136
What this trial is testing

Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

Who this might be right for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia With Gene Mutations+6 more
M.D. Anderson Cancer Center 54