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Results for “Deficient Mismatch Repair”

138 trials

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Showing 20 of 138 results

Testing effectiveness (Phase 2)Looking for participantsNCT06903858
What this trial is testing

Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer

Who this might be right for
Colorectal CancerMicrosatellite Instability HighMismatch Repair Deficiency
Sun Yat-sen University 105
Large-scale testing (Phase 3)Active Not RecruitingNCT04214067
What this trial is testing

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

Who this might be right for
Endometrial Endometrioid AdenocarcinomaStage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8Stage II Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
National Cancer Institute (NCI) 164
Large-scale testing (Phase 3)Looking for participantsNCT05236972
What this trial is testing

PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer

Who this might be right for
Colorectal Carcinoma
Sun Yat-sen University 323
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07807800
What this trial is testing

DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC)

Who this might be right for
Metastatic Colorectal Cancer (CRC)
D. E. Shaw Research, LLC 88
Testing effectiveness (Phase 2)Study completedNCT04082572
What this trial is testing

Pembrolizumab Before Surgery for the Treatment of Mismatch Repair Deficient Locally Advanced Solid Cancers

Who this might be right for
Locally Advanced Malignant Solid Neoplasm
M.D. Anderson Cancer Center 35
Early research (Phase 1)Ended earlyNCT04458259
What this trial is testing

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

Who this might be right for
Neoplasm Metastasis
Pfizer 88
Large-scale testing (Phase 3)Looking for participantsNCT06762405
What this trial is testing

PRODIGE 90 - (FFCD 2204) Neoadjuvant Dostarlimab with Short Course Radiotherapy in a Watch-and-wait Strategy for Microsatellite Unstable or Mismatch Repair-deficient Locally Advanced Rectal Cancer Patients

Who this might be right for
Rectal Adenocarcinoma with Mismatch-repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H)
Centre Hospitalier Universitaire Dijon 68
Not applicableLooking for participantsNCT07270666
What this trial is testing

CtDNA Testing to Inform Standard-of-Care Treatment Decisions in People With Endometrial Cancer

Who this might be right for
Endometrial Cancer
Memorial Sloan Kettering Cancer Center 30
Testing effectiveness (Phase 2)WithdrawnNCT04197219
What this trial is testing

Pembrolizumab With Axitinib in Recurrent Endometrial Cancer

Who this might be right for
Recurrent Endometrial Cancer
Case Comprehensive Cancer Center
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Not applicableLooking for participantsNCT06613165
What this trial is testing

Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer

Who this might be right for
Immune-related Adverse EventNeoadjuvant TherapydMMR Colorectal Cancer
Xijing Hospital 100
Testing effectiveness (Phase 2)Looking for participantsNCT04774419
What this trial is testing

Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery

Who this might be right for
Endometrial Cancer
Memorial Sloan Kettering Cancer Center 62
Not applicableUnknownNCT04516083
What this trial is testing

Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation

Who this might be right for
Cancer Gene MutationLynch SyndromeEndometrial Cancer+1 more
RWJ Barnabas Health at Jersey City Medical Center 100
Early research (Phase 1)Looking for participantsNCT06004245
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsColorectal Cancer
Vividion Therapeutics, Inc. 280
Not applicableUnknownNCT06004713
What this trial is testing

Registry Study in MSI/dMMR Solid Tumors

Who this might be right for
DMMR CancerMSI-HSolid Tumor
Peking University Cancer Hospital & Institute 190
Not applicableLooking for participantsNCT07472686
What this trial is testing

Small Bowel Capsule Endoscopy in Lynch Syndrome

Who this might be right for
MMR MutationSmall Bowel AdenomaSmall-bowel Adenocarcinoma+2 more
Assistance Publique - Hôpitaux de Paris 400
Not applicableLooking for participantsNCT07269249
What this trial is testing

Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
National Cancer Institute, Naples 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT04104893
What this trial is testing

CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
VA Office of Research and Development 40
Very early researchEnded earlyNCT04906382
What this trial is testing

Tislelizumab for the Treatment of Recurrent Mismatch Repair Deficient Endometrial Cancer

Who this might be right for
Lynch SyndromeRecurrent Endometrial CarcinomaRecurrent Endometrial Clear Cell Adenocarcinoma+4 more
Floor Backes, MD 2
Testing effectiveness (Phase 2)Looking for participantsNCT07811193
What this trial is testing

Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum

Who this might be right for
Colorectal Adenocarcinoma
Vividion Therapeutics, Inc. 140
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