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Results for “Deficient Mismatch Repair”

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Showing 20 of 0 results

Early research (Phase 1)Ended earlyNCT06034860
What this trial is testing

Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types

Who this might be right for
Non Small Cell Lung CancerHepatocellular CarcinomaMelanoma+8 more
Molecular Templates, Inc. 15
Large-scale testing (Phase 3)Not Yet RecruitingNCT07740720
What this trial is testing

The Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally Advanced Rectal Cancer

Who this might be right for
Neoplasms, Rectal
GlaxoSmithKline 90
Testing effectiveness (Phase 2)Looking for participantsNCT03926338
What this trial is testing

Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMismatch Repair-deficient (dMMR)Microsatellite Instability-high (MSI-H)+1 more
Sun Yat-sen University 270
Testing effectiveness (Phase 2)Active Not RecruitingNCT05426005
What this trial is testing

Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer Stage IVMismatch Repair-deficient (dMMR)Microsatellite Instability-high (MSI-H)
Sun Yat-sen University 28
Testing effectiveness (Phase 2)Active Not RecruitingNCT04556253
What this trial is testing

AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

Who this might be right for
MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
Peking University 47
Early research (Phase 1)Study completedNCT03894618
What this trial is testing

SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas

Who this might be right for
Squamous Cell Carcinoma of the Head and NeckMelanomaNon Small Cell Lung Cancer+10 more
Shattuck Labs, Inc. 49
Not applicableStudy completedNCT04482608
What this trial is testing

The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival

Who this might be right for
Colorectal Cancer MetastaticMismatch Repair DeficiencyMicrosatellite Instability High
Sun Yat-sen University 671
Large-scale testing (Phase 3)Looking for participantsNCT06686576
What this trial is testing

Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer

Who this might be right for
Colon Cancer
Qilu Pharmaceutical Co., Ltd. 363
Not applicableNot Yet RecruitingNCT07625735
What this trial is testing

MMR Status Modulates the Predictive Value of Lymphatic Invasion for Lymph Node Metastasis in Gastric Cancer

Who this might be right for
Gastric / Gastroesophageal Junction AdenocarcinomaMismatch Repair Deficient or MSI-High Solid TumorsLymph Node Metastasis+1 more
Shanghai Zhongshan Hospital 3,000
Testing effectiveness (Phase 2)WithdrawnNCT04001101
What this trial is testing

Anti-PD-1 +/- RT for MSI-H Solid Tumors

Who this might be right for
Microsatellite Instability HighMismatch Repair DeficiencyColorectal Cancer
University of Colorado, Denver
Testing effectiveness (Phase 2)Looking for participantsNCT06898450
What this trial is testing

Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

Who this might be right for
Advanced Solid Tumors CancerMSI-H Cancer
Nimbus Wadjet, Inc. 134
Testing effectiveness (Phase 2)Looking for participantsNCT06059495
What this trial is testing

DEWI: Watch-and-Wait With Dostarlimab in Localized dMMR/MSI-H Gastric/GEJ Adenocarcinoma Phase II Study

Who this might be right for
Adenocarcinoma - GEJGastric Adenocarcinoma
GERCOR - Multidisciplinary Oncology Cooperative Group 89
Testing effectiveness (Phase 2)Looking for participantsNCT06529523
What this trial is testing

Tislelizumab in People With Colorectal Cancer

Who this might be right for
Colorectal Cancer
Memorial Sloan Kettering Cancer Center 40
Large-scale testing (Phase 3)Active Not RecruitingNCT02997228
What this trial is testing

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

Who this might be right for
Metastatic Colorectal AdenocarcinomaStage IV Colorectal Cancer AJCC v7
National Cancer Institute (NCI) 120
Testing effectiveness (Phase 2)Ended earlyNCT04258111
What this trial is testing

IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 4
Early research (Phase 1)Not Yet RecruitingNCT07809607
What this trial is testing

Evaluate YF087 in Subjects With MSI-H or dMMR Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor Cancer
InventisBio Co., Ltd 70
Not applicableStudy completedNCT07838246
What this trial is testing

Liquid Biopsy Biomarkers for Endoscopic Surveillance in Lynch Syndrome

Who this might be right for
Lynch SyndromeHereditary Nonpolyposis Colorectal CancerHNPCC+2 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 109
Early research (Phase 1)Looking for participantsNCT07403721
What this trial is testing

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

Who this might be right for
Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)
Amgen 464
Large-scale testing (Phase 3)Looking for participantsNCT07412613
What this trial is testing

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Who this might be right for
Resectable Colon CancerMSI-H/dMMR Colorectal Cancer
Akeso 386
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
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