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Results for “Deficient Mismatch Repair”

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Enrolling by Invitation

Showing 20 of 0 results

Testing effectiveness (Phase 2)Looking for participantsNCT06580574
What this trial is testing

Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers

Who this might be right for
Gastric CancerColon CancerMSI-H+1 more
Peking University 34
Testing effectiveness (Phase 2)Looking for participantsNCT07262619
What this trial is testing

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Who this might be right for
Advanced Solid TumorsMSI-H or dMMR Advanced Solid TumorsMSI-H/dMMR Gastric Cancer+4 more
Eikon Therapeutics 160
Testing effectiveness (Phase 2)Looking for participantsNCT04165772
What this trial is testing

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Who this might be right for
Rectal AdenocarcinomaClinical Stage: Stage II (T3-4, N-)Stage III (Any T, N+)+2 more
Memorial Sloan Kettering Cancer Center 212
Not applicableNot Yet RecruitingNCT07689812
What this trial is testing

Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.

Who this might be right for
NSCLC (Advanced Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Carcinoma)+12 more
Natera, Inc. 920
Testing effectiveness (Phase 2)Enrolling By InvitationNCT07542262
What this trial is testing

Low-dose Immunotherapy in Metastatic and Locally Advanced Colorectal and Gastric MSI/dMMR Cancers

Who this might be right for
Colorectal CancerGastric Cancer
Blokhin's Russian Cancer Research Center 128
Early research (Phase 1)Ended earlyNCT06625515
What this trial is testing

First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers

Who this might be right for
Advanced Solid TumorsBreast Cancer RecurrentColorectal Cancer Metastatic+3 more
Accent Therapeutics 17
Testing effectiveness (Phase 2)Active Not RecruitingNCT06710847
What this trial is testing

Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

Who this might be right for
Neoplasms, ColorectalSolid TumorColon Cancer+2 more
GlaxoSmithKline 14
Early research (Phase 1)Not Yet RecruitingNCT07552376
What this trial is testing

This Study Aims to Evaluate the Efficacy and Safety of QLS1317 in Patients With MSI-H/dMMR Advanced Solid Tumors.

Who this might be right for
MSI-H or dMMR Advanced Solid Tumors
Shanghai Qilu Pharmaceutical Research and Development Center LTD 120
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07403877
What this trial is testing

Neoadjuvant Immunotherapy ± Radiotherapy in MSI-H/dMMR Locally Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer (MSI-H)
Fudan University 114
Early research (Phase 1)Ended earlyNCT05909995
What this trial is testing

Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors

Who this might be right for
MelanomaHepatocellular Carcinoma (HCC)Renal Cell Carcinoma (RCC)+3 more
Incyte Corporation 8
Testing effectiveness (Phase 2)Ended earlyNCT04547101
What this trial is testing

AK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid Tumors

Who this might be right for
MSI-H/dMMR Solid Tumor
Akeso 6
Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Testing effectiveness (Phase 2)UnknownNCT04326829
What this trial is testing

QL1604 Monotherapy for dMMR or MSI-H Advanced Solid Tumors

Who this might be right for
Advanced Malignant Tumor
Qilu Pharmaceutical Co., Ltd. 86
Large-scale testing (Phase 3)Study completedNCT02563002
What this trial is testing

Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177)

Who this might be right for
Colorectal Carcinoma
Merck Sharp & Dohme LLC 307
Testing effectiveness (Phase 2)Active Not RecruitingNCT03767348
What this trial is testing

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Microsatellite Instability-High (MSI-H)Non-melanoma Skin Cancer (NMSC)+1 more
Replimune, Inc. 340
Not applicableLooking for participantsNCT06549855
What this trial is testing

PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer

Who this might be right for
Endometrial CancerEndometrioid CarcinomaMismatch Repair Deficiency
Peking University People's Hospital 10
Testing effectiveness (Phase 2)Active Not RecruitingNCT03935893
What this trial is testing

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Who this might be right for
Gastric CancerColorectal CancerPancreatic Cancer+7 more
Udai Kammula 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06426654
What this trial is testing

Sintilimab Combined With LDRT for Neoadjuvant Treatment of Locally Advanced dMMR/MSI-H Gastric Cancer

Who this might be right for
Gastric Cancer
West China Hospital 45
Testing effectiveness (Phase 2)Active Not RecruitingNCT04895722
What this trial is testing

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

Who this might be right for
Colorectal Cancer
Merck Sharp & Dohme LLC 302
Early research (Phase 1)Study completedNCT02052908
What this trial is testing

Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome

Who this might be right for
Lynch Syndrome
National Cancer Institute (NCI) 81
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