Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Depressive Disorder, Treatment-Resistant”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Large-scale testing (Phase 3)Study completedNCT00789854
What this trial is testing

Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients

Who this might be right for
Major Depressive DisorderTreatment Resistant Depression
AstraZeneca 688
Post-approval studies (Phase 4)Looking for participantsNCT07369102
What this trial is testing

Esketamine With or Without Integration Therapy for Treatment-Resistant Depression

Who this might be right for
Treatment-resistant Depression (TRD)
University of Puerto Rico 20
Testing effectiveness (Phase 2)Looking for participantsNCT07553637
What this trial is testing

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

Who this might be right for
Treatment-resistant Depression (TRD)
Alto Neuroscience 178
Not applicableStudy completedNCT00971815
What this trial is testing

Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight

Who this might be right for
Insulin ResistanceLow Birth WeightType 2 Diabetes+3 more
University of Aarhus 60
Early research (Phase 1)UnknownNCT05117710
What this trial is testing

IMPase in Treatment-resistant Depression

Who this might be right for
Depressive Disorder, Treatment-Resistant
University of Oxford 50
Not applicableStudy completedNCT01973478
What this trial is testing

Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression

Who this might be right for
Major Depressive DisorderRecurrent Depressive DisorderBipolar Disorder
Rennes University Hospital 9
Not applicableWithdrawnNCT04195308
What this trial is testing

SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty

Who this might be right for
Treatment Resistant Depression
Stanford University
Testing effectiveness (Phase 2)Study completedNCT01778790
What this trial is testing

Deep Brain Stimulation of the Superolateral Branch of the Medial Forebrain Bundle (slMFB) for the Treatment of Refractory Major Depression

Who this might be right for
Major Depression
University Hospital, Bonn 16
Large-scale testing (Phase 3)Study completedNCT02493868
What this trial is testing

Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

Who this might be right for
Depressive Disorder, Treatment-Resistant
Janssen Research & Development, LLC 719
Testing effectiveness (Phase 2)Study completedNCT05800860
What this trial is testing

A Trial of GH001 in Patients With Treatment-resistant Depression

Who this might be right for
Treatment-resistant Depression
GH Research Ireland Limited 81
Not applicableStudy completedNCT06953362
What this trial is testing

Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression

Who this might be right for
Treatment Resistant Depression
University of California, San Francisco 6
Testing effectiveness (Phase 2)Ended earlyNCT04634669
What this trial is testing

Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)

Who this might be right for
Treatment Resistant DepressionMajor Depressive Disorder
Axsome Therapeutics, Inc. 181
Testing effectiveness (Phase 2)Looking for participantsNCT02122562
What this trial is testing

Ketamine Alcohol (in Treatment-Resistant Depression)

Who this might be right for
Magnetic Resonance ImagingMajor DepressionAlcoholism
Mark Niciu 60
Not applicableStudy completedNCT07526454
What this trial is testing

Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder

Who this might be right for
Electroconvulsive TherapyIntravenous KetamineTreatment-Resistant+1 more
Tanta University 70
Post-approval studies (Phase 4)Not Yet RecruitingNCT07680140
What this trial is testing

Biomarker-Guided Antidepressant Selection

Who this might be right for
Depression - Major Depressive DisorderTreatment-resistant Depression (TRD)rTMS+2 more
Weill Medical College of Cornell University 27
Post-approval studies (Phase 4)Study completedNCT04957368
What this trial is testing

Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial

Who this might be right for
Treatment Resistant DepressionMajor Depressive Disorder
Unity Health Toronto 40
Very early researchStudy completedNCT04977674
What this trial is testing

Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine

Who this might be right for
Depressive Disorder, Treatment-Resistant
King's College London 27
Not applicableStudy completedNCT02971150
What this trial is testing

Treatment Resistant Depression and Insomnia in Older Veterans

Who this might be right for
Treatment Resistant DepressionInsomnia
VA Pittsburgh Healthcare System 12
Testing effectiveness (Phase 2)Study completedNCT04437485
What this trial is testing

EIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk

Who this might be right for
DepressionMajor Depressive DisorderDysthymic Disorder+4 more
Indiana University 46
Large-scale testing (Phase 3)Active Not RecruitingNCT05625555
What this trial is testing

Predictors of Intravenous Ketamine Response in TRD

Who this might be right for
Treatment Resistant DepressionMajor Depressive DisorderBipolar Disorder
Abraham Nunes 40
Next Page