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Results for “Developmental and Epileptic Encephalopathy”

49 trials

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Showing 20 of 49 results

Testing effectiveness (Phase 2)Looking for participantsNCT07227857
What this trial is testing

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Who this might be right for
Epileptic Encephalopathy
Institut de Recherches Internationales Servier 20
Testing effectiveness (Phase 2)UnknownNCT03944447
What this trial is testing

Outcomes Mandate National Integration With Cannabis as Medicine

Who this might be right for
Chronic PainChronic Pain SyndromeChronic Pain Due to Injury+30 more
OMNI Medical Services, LLC 200,000
Not applicableEnded earlyNCT04537832
What this trial is testing

Natural History Study of Infants and Children With Developmental and Epileptic Encephalopathies

Who this might be right for
Dravet Syndrome
Encoded Therapeutics 58
Not applicableLooking for participantsNCT06092346
What this trial is testing

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Who this might be right for
AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more
National Human Genome Research Institute (NHGRI)
Large-scale testing (Phase 3)Looking for participantsNCT07019922
What this trial is testing

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

Who this might be right for
Epileptic EncephalopathySCN2A Encephalopathy
Praxis Precision Medicines 50
Large-scale testing (Phase 3)Looking for participantsNCT06719141
What this trial is testing

Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

Who this might be right for
Developmental and Epileptic Encephalopathy
Longboard Pharmaceuticals 320
Very early researchActive Not RecruitingNCT04937062
What this trial is testing

Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy

Who this might be right for
STXBP1 Encephalopathy With Epilepsy, SLC6A1 Neurodevelopmental DisorderDevelopmental and Epileptic Encephalopathy
Weill Medical College of Cornell University 50
Large-scale testing (Phase 3)Looking for participantsNCT06660394
What this trial is testing

A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)

Who this might be right for
Dravet Syndrome
Longboard Pharmaceuticals 160
Large-scale testing (Phase 3)Active Not RecruitingNCT05818553
What this trial is testing

A Clinical Trial of PRAX-562 in Subjects With Developmental and Epileptic Encephalopathies (DEE)

Who this might be right for
SCN2A EncephalopathySCN8A Encephalopathy
Praxis Precision Medicines 77
Testing effectiveness (Phase 2)Study completedNCT03650452
What this trial is testing

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies

Who this might be right for
EpilepsyDravet SyndromeLennox-Gastaut Syndrome
Takeda 141
Not applicableLooking for participantsNCT06792396
What this trial is testing

Study of Patients with Electrical Status Epilepticus in Sleep

Who this might be right for
Electrical Status Epilepticus in Sleep
East Suffolk and North Essex NHS Foundation Trust 20
Not applicableStudy completedNCT05687474
What this trial is testing

Baby Detect : Genomic Newborn Screening

Who this might be right for
Congenital Adrenal HyperplasiaFamilial Hyperinsulinemic Hypoglycemia 1Phosphoglucomutase 1 Deficiency+121 more
Centre Hospitalier Universitaire de Liege 6,824
Not applicableLooking for participantsNCT01238250
What this trial is testing

Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

Who this might be right for
16P11.2 Deletion Syndrome16p11.2 Duplications1Q21.1 Deletion+181 more
Simons Searchlight 100,000
Not applicableUnknownNCT05722990
What this trial is testing

Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam

Who this might be right for
Whole Exome SequencingEpileptic Encephalopathy
Number 2 Children's Hospital, Ho Chi Minh City 150
Testing effectiveness (Phase 2)Study completedNCT06412653
What this trial is testing

Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders

Who this might be right for
GNAO1DystoniaEpilepsy+4 more
Children's University Hospital Cologne, Germany 13
Large-scale testing (Phase 3)Looking for participantsNCT07010471
What this trial is testing

A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine

Who this might be right for
Developmental and Epileptic Encephalopathy 1
Praxis Precision Medicines 160
Testing effectiveness (Phase 2)Study completedNCT05364021
What this trial is testing

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies

Who this might be right for
Developmental and Epileptic EncephalopathyDravet SyndromeLennox Gastaut Syndrome
Longboard Pharmaceuticals 52
Not applicableEnrolling By InvitationNCT06938542
What this trial is testing

Palliative Care Needs of Children With Rare Diseases and Their Families

Who this might be right for
Trisomy 13 SyndromeArthrogryposis Congenita Multiplex With Intestinal AtresiaAsparagine Synthetase Deficiency+16 more
Children's National Research Institute 480
Large-scale testing (Phase 3)Ended earlyNCT04912856
What this trial is testing

An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE

Who this might be right for
EpilepsyEpilepsy in ChildrenEpilepsy; Seizure+5 more
Xenon Pharmaceuticals Inc. 8
Testing effectiveness (Phase 2)Active Not RecruitingNCT06112275
What this trial is testing

A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (Australia Only)

Who this might be right for
Dravet Syndrome
Encoded Therapeutics 4
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