Not applicableStudy completedNCT05629520What this trial is testingA Neurobiological Model of AnhedoniaWho this might be right forAnhedoniaDepression Milton S. Hershey Medical Center 60
Not applicableStudy completedNCT03939676What this trial is testingEvaluating Motivation and Reward Mechanisms and Brain Substrates in Adults With ObesityWho this might be right forAnhedoniaObesity Brain and Cognition Discovery Foundation 12
Not applicableActive Not RecruitingNCT07199179What this trial is testingLink Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and AnhedoniaWho this might be right forDepression - Major Depressive DisorderDepression DisorderSuicide University Hospital, Montpellier 456
Not applicableStudy completedNCT05756530What this trial is testingThe Experience of Affective Touch in Anorexia NervosaWho this might be right forAnorexia Nervosa Istituto Auxologico Italiano 60
Testing effectiveness (Phase 2)UnknownNCT03915613What this trial is testingBrain Insulin Resistance in Mood DisordersWho this might be right forMajor Depressive DisorderBipolar DisorderAnhedonia+1 more University Health Network, Toronto 150
Large-scale testing (Phase 3)Study completedNCT05550532What this trial is testingAticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 444
Testing effectiveness (Phase 2)Study completedNCT04121091What this trial is testingPramipexole to Target "Anhedonic Depression"Who this might be right forDepression, BipolarDepression, UnipolarDysthymia+1 more Region Skane 13
Large-scale testing (Phase 3)Ended earlyNCT06635135What this trial is testingAticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and PleasureWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 47
Not applicableEnrolling By InvitationNCT07467473What this trial is testingCausal Role of Rostromedial Prefrontal Cortex for Positive Savoring in DepressionWho this might be right forLeft Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta BurstLeft Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta BurstLeft Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst Florida State University 48
Testing effectiveness (Phase 2)Study completedNCT04827901What this trial is testingXEN1101 for Major Depressive DisorderWho this might be right forMajor Depressive Disorder James Murrough 44
Not applicableNot Yet RecruitingNCT07032428What this trial is testingEfficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of AnhedoniaWho this might be right forAnhedonia in Major Depressive Disorder Magnetic Tides 80
Not applicableLooking for participantsNCT07476469What this trial is testingTVNS and Approach-Avoidance Behavior in Anhedonia and AnxietyWho this might be right forHealthy ParticipantsAnxiety Disorders (With High Anxiety Symptoms)Depressive Disorders (With High Anhedonia Symptoms)+1 more Dr. Nils B. Kroemer 104
Not applicableStudy completedNCT05870501What this trial is testingSynaptic Imaging and Network Activity in Treatment Resistant DepressionWho this might be right forDepressive DisorderDepressive Disorder, MajorDepressive Disorder, Treatment-Resistant+5 more King's College London 56
Early research (Phase 1)Study completedNCT03369015What this trial is testingEffect of D-amphetamine on Reward FunctioningWho this might be right forAnhedonia The University of Texas Health Science Center, Houston 68
Not applicableEnded earlyNCT02915484What this trial is testingTranscranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke ApathyWho this might be right forApathyStroke Stony Brook University 12
Post-approval studies (Phase 4)Looking for participantsNCT06075771What this trial is testingDopaminergic Therapy for Anhedonia - 2Who this might be right forAnhedoniaDepression Emory University 70
Early research (Phase 1)Not Yet RecruitingNCT07607938What this trial is testingPsilocybin as a Novel Therapy for Residual AnhedoniaWho this might be right forAnhedoniaEmotional Blunting NYU Langone Health 90
Early research (Phase 1)UnknownNCT05320107What this trial is testingThe Effect of Ketamine on Aesthetics and Role for Antidepressant EffectsWho this might be right forMajor Depressive Disorder Medical University of Vienna 60
Not applicableUnknownNCT05234476What this trial is testingBehavioral Activation Plus Savoring for University StudentsWho this might be right forMoodAnhedoniaDepression Southern Methodist University 60
Post-approval studies (Phase 4)Study completedNCT02513485What this trial is testingInflammation-related Alterations in Neurocircuitry: Reversal With LevodopaWho this might be right forDepression Emory University 57