Post-approval studies (Phase 4)Study completedNCT05487885What this trial is testingAnhedonia, Development, and Emotions: Phenotyping and TherapeuticsWho this might be right forDepressionAnhedonia Erika Forbes 123
Not applicableEnded earlyNCT02915484What this trial is testingTranscranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke ApathyWho this might be right forApathyStroke Stony Brook University 12
Not applicableLooking for participantsNCT06096740What this trial is testingPsychotherapy Effects on Reward Processing in PTSDWho this might be right forPost Traumatic Stress DisorderDiminished PleasureAnhedonia+3 more University of Texas at Austin 120
Not applicableStudy completedNCT06576440What this trial is testingEffects of Ghrelin Administration on MotivationWho this might be right forMajor Depressive Disorder University Hospital Tuebingen 24
Post-approval studies (Phase 4)Study completedNCT02513485What this trial is testingInflammation-related Alterations in Neurocircuitry: Reversal With LevodopaWho this might be right forDepression Emory University 57
Post-approval studies (Phase 4)Looking for participantsNCT05282277What this trial is testingExamining the Effects of Estradiol on Neural and Molecular Response to RewardWho this might be right forDepressionPsychosisAnhedonia University of North Carolina, Chapel Hill 103
Not applicableLooking for participantsNCT05617898What this trial is testingDetermining the Role of Social Reward Learning in Social AnhedoniaWho this might be right forPsychosis University of Alabama at Birmingham 152
Not applicableStudy completedNCT04977232What this trial is testingAdjunctive Game Intervention for Anhedonia in MDD PatientsWho this might be right forDepression Central South University 50
Early research (Phase 1)Study completedNCT05342077What this trial is testingVirtual Reality-Reward Training for AnhedoniaWho this might be right forPositive AffectDepression University of California, Los Angeles 59
Not applicableStudy completedNCT03904186What this trial is testingEffectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIVWho this might be right forHuman Immunodeficiency VirusSmoking CessationSmoking, Cigarette+4 more Massachusetts General Hospital 131
Testing effectiveness (Phase 2)Study completedNCT05165394What this trial is testingStudy to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDDWho this might be right forAnhedoniaMajor Depressive Disorder Neurocrine Biosciences 93
Not applicableLooking for participantsNCT05384158What this trial is testingValuation in Depressed Mood, Anhedonia, and AnxietyWho this might be right forNeurobehavioral Components of Reward and Loss Valuation Virginia Polytechnic Institute and State University 252
Not applicableLooking for participantsNCT05691439What this trial is testingMechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain FunctionWho this might be right forDepression in Adolescence University of Oregon 150
Not applicableUnknownNCT06111664What this trial is testingAnergia-anhedonia by Lithium-induced Phosphorus DiabetesWho this might be right forMood Disorders University Hospital, Strasbourg, France 60
Large-scale testing (Phase 3)Ended earlyNCT06635135What this trial is testingAticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and PleasureWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 48
Testing effectiveness (Phase 2)WithdrawnNCT05601648What this trial is testingPET Synaptogenesis After Psilocybin In DEpression RecoveryWho this might be right forMajor Depressive DisorderAnhedonia Washington University School of Medicine
Not applicableStudy completedNCT03939676What this trial is testingEvaluating Motivation and Reward Mechanisms and Brain Substrates in Adults With ObesityWho this might be right forAnhedoniaObesity Brain and Cognition Discovery Foundation 12
Not applicableLooking for participantsNCT06270433What this trial is testingEfficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets Versus Desvenlafaxine Succinate Sustained-release Tablets Targeting Anhedonia in Patients With Major Depression DisorderWho this might be right forAnhedonia Jiangsu Province Nanjing Brain Hospital 80
Large-scale testing (Phase 3)Study completedNCT05550532What this trial is testingAticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 444
Early research (Phase 1)Study completedNCT03848715What this trial is testingSleep and Healthy Aging Research on Depression for Younger WomenWho this might be right forAnhedoniaDepression University of California, Los Angeles 40