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Results for “EGFRvIII”

33 trials

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Showing 20 of 33 results

Not applicableStudy completedNCT02666248
What this trial is testing

Long-term Follow-up of Subjects Exposed to Lentiviral-based CART-EGFRvIII Gene-modified Cellular Therapy Products in Cancer Studies

Who this might be right for
Subjects Entering Into This Protocol Will be Followed for up to 15 Years After Initial CART-EGFRvIII Infusion
University of Pennsylvania 3
Early research (Phase 1)Not Yet RecruitingNCT07579208
What this trial is testing

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

Who this might be right for
Phase 1NK CellIL13Ra+4 more
M.D. Anderson Cancer Center 36
Testing effectiveness (Phase 2)Looking for participantsNCT07326566
What this trial is testing

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Who this might be right for
Glioblastoma (GBM)Newly Diagnosed GlioblastomaGBM+4 more
Black Diamond Therapeutics, Inc. 162
Not applicableUnknownNCT03058198
What this trial is testing

The Research on 89Zr-ABT806 PET Imaging in High Grade Glioma

Who this might be right for
Glioma
Huashan Hospital 40
Early research (Phase 1)Ended earlyNCT00023634
What this trial is testing

S0114 Vaccine Therapy in Treating Patients With Gastric, Prostate, or Ovarian Cancer

Who this might be right for
Brain TumorsGastric CancerOvarian Cancer+1 more
SWOG Cancer Research Network 14
Early research (Phase 1)Looking for participantsNCT07480941
What this trial is testing

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

Who this might be right for
GlioblastomaHigh-grade GliomaMalignant Glioma+2 more
Beijing Biotech 36
Very early researchNot Yet RecruitingNCT07244666
What this trial is testing

Safety and Preliminary Efficacy of a Metabolically Armed Chimeric Antigen Receptor T Cell Therapy Targeting EGFRvIII for Recurrent Glioblastoma

Who this might be right for
Glioblastoma (GBM)
Second Affiliated Hospital, School of Medicine, Zhejiang University 36
Early research (Phase 1)Study completedNCT01475006
What this trial is testing

AMG 595 First-in-Human in Recurrent Gliomas

Who this might be right for
Advanced Malignant GliomaAnaplastic AstrocytomasGlioblastoma Multiforme
Amgen 32
Testing effectiveness (Phase 2)Looking for participantsNCT02861898
What this trial is testing

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Who this might be right for
GlioblastomaBrain CancerBrain Neoplasm+4 more
Northwell Health 33
Early research (Phase 1)Study completedNCT02378532
What this trial is testing

The Addition of Chloroquine to Chemoradiation for Glioblastoma

Who this might be right for
Glioblastoma Multiforme
Maastricht Radiation Oncology 13
Testing effectiveness (Phase 2)Study completedNCT01454596
What this trial is testing

CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII

Who this might be right for
Malignant GliomaGlioblastomaBrain Cancer+1 more
National Cancer Institute (NCI) 18
Early research (Phase 1)Study completedNCT03726515
What this trial is testing

CART-EGFRvIII + Pembrolizumab in GBM

Who this might be right for
Glioblastoma
University of Pennsylvania 7
Early research (Phase 1)Study completedNCT01238237
What this trial is testing

Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA

Who this might be right for
Glioblastoma Multiforme (GBM)ANAPLASTIC ASTROCYTOMA (AOA)GBM+1 more
Northwell Health 15
Testing effectiveness (Phase 2)Study completedNCT01498328
What this trial is testing

Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Who this might be right for
GlioblastomaSmall Cell GlioblastomaGiant Cell Glioblastoma+4 more
Celldex Therapeutics 127
Very early researchUnknownNCT05802693
What this trial is testing

Evaluate the Safety, Tolerance and Initial Efficacy of EGFRvIII CAR-T on Glioblastoma

Who this might be right for
Recurrent Glioblastoma
Beijing Tsinghua Chang Gung Hospital 22
Early research (Phase 1)Looking for participantsNCT07551336
What this trial is testing

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

Who this might be right for
Malignant GliomaHigh-Grade GliomasGlioblastoma+2 more
Beijing Biotech 36
Testing effectiveness (Phase 2)Looking for participantsNCT07523529
What this trial is testing

Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid Tumors

Who this might be right for
Advanced UnresectableMetastatic
Beijing Biotech 72
Testing effectiveness (Phase 2)Study completedNCT01520870
What this trial is testing

Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.

Who this might be right for
GlioblastomaBrain Tumor, Recurrent
Grupo Español de Investigación en Neurooncología 49
Testing effectiveness (Phase 2)Study completedNCT00458601
What this trial is testing

Phase II Study of Rindopepimut (CDX-110) in Patients With Glioblastoma Multiforme

Who this might be right for
Malignant Glioma
Celldex Therapeutics 82
Testing effectiveness (Phase 2)UnknownNCT03941626
What this trial is testing

Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies

Who this might be right for
Esophagus CancerHepatomaGlioma+1 more
Shenzhen BinDeBio Ltd. 50
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