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Results for “ESR1 Gene Mutation”

37 trials

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Showing 20 of 37 results

Early research (Phase 1)WithdrawnNCT04602117
What this trial is testing

ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer

Who this might be right for
HER2-positive Breast CancerHER2 LowSYD-985+24 more
QuantumLeap Healthcare Collaborative
Not applicableLooking for participantsNCT06417801
What this trial is testing

Prevalence of Emerging Treatment-induced Mutations in Metastatic ER-positive Breast Cancer.

Who this might be right for
Metastatic Breast Cancer
AstraZeneca 70
Post-approval studies (Phase 4)Looking for participantsNCT05183828
What this trial is testing

Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer

Who this might be right for
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8+2 more
University of Washington 68
Early research (Phase 1)Ended earlyNCT02476955
What this trial is testing

Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole

Who this might be right for
Solid TumorsOvarian CancerEndometrial Cancer
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 41
Not applicableLooking for participantsNCT06127979
What this trial is testing

Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 42
Testing effectiveness (Phase 2)Study completedNCT04432454
What this trial is testing

Evaluation of Lasofoxifene Combined With Abemaciclib in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Who this might be right for
Metastatic Breast Cancer
Sermonix Pharmaceuticals Inc. 29
Early research (Phase 1)Active Not RecruitingNCT02432963
What this trial is testing

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Who this might be right for
Adult Solid NeoplasmBladder CarcinomaColon Carcinoma+14 more
City of Hope Medical Center 11
Large-scale testing (Phase 3)Looking for participantsNCT06382948
What this trial is testing

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

Who this might be right for
Advanced Breast CancerER-positive Breast CancerHER2-negative Breast Cancer+1 more
MedSIR 240
Testing effectiveness (Phase 2)UnknownNCT03879174
What this trial is testing

Pembrolizumab And Tamoxifen Among Women With Advanced Hormone Receptor Positive Breast Cancer And Esr1 Mutation

Who this might be right for
Breast Cancer Female
Mediclinic Middle East 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07499999
What this trial is testing

Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer

Who this might be right for
Breast CancerDuctal CarcinomaEstrogen-receptor-positive Breast Cancer+4 more
Dana-Farber Cancer Institute 140
Testing effectiveness (Phase 2)Looking for participantsNCT07222215
What this trial is testing

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Who this might be right for
Estrogen-receptor-positive Breast CancerMetastatic Breast CancerBreast Cancer+6 more
Kristina A. Fanucci 297
Large-scale testing (Phase 3)Looking for participantsNCT05696626
What this trial is testing

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Who this might be right for
Metastatic Breast Cancer
LeonaBio 500
Early research (Phase 1)UnknownNCT04631835
What this trial is testing

Phase I Study of the HS-10352 in Patients With Advanced Breast Cancer

Who this might be right for
Breast Cancer
Jiangsu Hansoh Pharmaceutical Co., Ltd. 54
Not applicableStudy completedNCT00342498
What this trial is testing

Estrogen Receptor Gene Mutations

Who this might be right for
MutationsHormones
National Institute of Environmental Health Sciences (NIEHS)
Testing effectiveness (Phase 2)Study completedNCT03781063
What this trial is testing

Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Who this might be right for
Locally Advanced or Metastatic Breast Cancer
Sermonix Pharmaceuticals Inc. 100
Early research (Phase 1)Study completedNCT01219699
What this trial is testing

BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene

Who this might be right for
Advanced Solid Tumors With an Alteration of the PIK3CA GeneEstrogen Receptor Positive Breast Cancer
Novartis Pharmaceuticals 221
Not applicableLooking for participantsNCT06544577
What this trial is testing

Safety of Elacestrant in ER+/HER2- and ESR1 Mutations MBC

Who this might be right for
ESR1 Gene MutationAdvanced Breast CancerSafety
SciClone Pharmaceuticals 350
Not applicableEnded earlyNCT01346579
What this trial is testing

Biomarkers in Tissue Samples From Older Women With Breast Cancer

Who this might be right for
Breast Cancer
Alliance for Clinical Trials in Oncology 505
Large-scale testing (Phase 3)UnknownNCT03544762
What this trial is testing

Correlation of 16α-[18F]Fluoro-17β-estradiol PET Imaging With ESR1 Mutation

Who this might be right for
Breast Cancer
National Taiwan University Hospital 60
Large-scale testing (Phase 3)Study completedNCT03079011
What this trial is testing

PAlbociclib and Circulating Tumor DNA for ESR1 Mutation Detection

Who this might be right for
Metastatic Breast Cancer
UNICANCER 1,017
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