Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Enzyme Deficiency”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Not applicableStudy completedNCT00328159
What this trial is testing

Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids

Who this might be right for
Inborn Errors of Metabolism
Assistance Publique - Hôpitaux de Paris 20
Not applicableStudy completedNCT00103883
What this trial is testing

A Novel Method to Determine HIV Incidence Among Youth

Who this might be right for
HIV Infection
University of North Carolina, Chapel Hill 440
Testing effectiveness (Phase 2)Looking for participantsNCT06887777
What this trial is testing

Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)

Who this might be right for
Pyruvate Dehydrogenase Complex Deficiency Disease
Assistance Publique - Hôpitaux de Paris 15
Testing effectiveness (Phase 2)Active Not RecruitingNCT02171104
What this trial is testing

MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

Who this might be right for
Mucopolysaccharidosis DisordersHurler SyndromeHunter Syndrome+26 more
Masonic Cancer Center, University of Minnesota 149
Not applicableStudy completedNCT03878069
What this trial is testing

Registry Study of Revcovi Treatment in Patients With ADA-SCID

Who this might be right for
Adenosine Deaminase Severe Combined Immunodeficiency
Chiesi Farmaceutici S.p.A. 32
Testing effectiveness (Phase 2)Study completedNCT00786422
What this trial is testing

Deep Vein Thrombosis Treatment With the Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients Using a Strong CYP 3A4 Inducer

Who this might be right for
Venous ThrombosisDeep Vein Thrombosis
Bayer 25
Not applicableLooking for participantsNCT04885179
What this trial is testing

SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)

Who this might be right for
SphingolipidosesEnzyme Deficiency
University of California, San Francisco 120
Testing effectiveness (Phase 2)Study completedNCT01307098
What this trial is testing

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Who this might be right for
Cholesterol Ester Storage Disease(CESD)Lysosomal Acid Lipase DeficiencyLAL-Deficiency
Alexion Pharmaceuticals, Inc. 9
Not applicableStudy completedNCT03334968
What this trial is testing

Prolidase Enzyme Activity in Stroke Patients

Who this might be right for
Stroke, IschemicProlidase Deficiency
Bezmialem Vakif University 74
Not applicableUnknownNCT05300347
What this trial is testing

Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)

Who this might be right for
BronchiectasisAdenosine Deaminase DeficiencyPulmonary Disease
TRPHARM 500
Early research (Phase 1)Study completedNCT01894165
What this trial is testing

Phase 1 Single Dose Study of ALXN1101 in Healthy Volunteers

Who this might be right for
Molybdenum Cofactor Deficiency (MoCD)Rare Autosomal Recessive DisorderDeficiency of Activity of Molybdenum-dependent Enzymes (Sulfite Oxidase [SOX], Xanthine Dehydrogenase, and Aldehyde Oxidase)
Origin Biosciences 24
Not applicableLooking for participantsNCT01665326
What this trial is testing

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Who this might be right for
Pompe Disease
Duke University 400
Large-scale testing (Phase 3)Study completedNCT00006396
What this trial is testing

Effectiveness of AZT and Nevirapine in Preventing HIV Transmission From Ugandan Mothers to Their Newborns

Who this might be right for
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID) 1,500
Large-scale testing (Phase 3)Study completedNCT00006327
What this trial is testing

Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand

Who this might be right for
HIV InfectionsHIV Seronegativity
VaxGen 2,500
Early research (Phase 1)Ended earlyNCT00410566
What this trial is testing

Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)

Who this might be right for
Acid Sphingomyelinase DeficiencyNiemann-Pick Disease
Genzyme, a Sanofi Company 11
Not applicableStudy completedNCT02418221
What this trial is testing

A Provocation Study Using Biogenic Amines to Show the Efficacy of Oral Diamine Oxidase Supplementation

Who this might be right for
Histamine Intolerance
IPSC AG 72
Not applicableUnknownNCT05300373
What this trial is testing

Evaluation of Adenosine Deaminase (ADA) Enzyme Deficiency in Patients With Lymphopenia and/or Elevated Immunoglobulin E

Who this might be right for
Adenosine Deaminase Deficiency
TRPHARM 100
Early research (Phase 1)Study completedNCT04723602
What this trial is testing

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

Who this might be right for
Ebola Virus DiseaseMarburg Virus Disease
Albert B. Sabin Vaccine Institute 32
Early research (Phase 1)Study completedNCT02819102
What this trial is testing

An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates

Who this might be right for
Hereditary Angioedema
BioCryst Pharmaceuticals 20
Testing effectiveness (Phase 2)UnknownNCT04556071
What this trial is testing

Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer

Who this might be right for
Ovarian NeoplasmsFallopian Tube NeoplasmsEndocrine Gland Neoplasms+21 more
Xiaoxiang Chen 32
Next Page