Very early researchUnknownNCT03993821What this trial is testingBurosumab for CSHSWho this might be right forCutaneous Skeletal Hypophosphatemia Syndrome (CSHS)Epidermal Nevus Syndrome Laura Tosi 1
Testing effectiveness (Phase 2)Looking for participantsNCT06789913What this trial is testingMutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA MutationWho this might be right forPIK3CA-Related Overgrowth Spectrum (PROS)Lymphatic MalformationsVascular Malformations+4 more Relay Therapeutics, Inc. 277
Not applicableLooking for participantsNCT03001180What this trial is testingIdentification of Biomarkers for Patients with Vascular AnomaliesWho this might be right forVascular AnomalyGeneralized Lymphatic AnomalyKaposiform Hemangioendothelioma+4 more Children's Hospital Medical Center, Cincinnati 1,000
Testing effectiveness (Phase 2)Looking for participantsNCT07070232What this trial is testingA Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant TumorsWho this might be right forAdvanced Solid Tumor BioNTech SE 980
Post-approval studies (Phase 4)Study completedNCT04320316What this trial is testingA Trial to Assess the Safety and Efficacy of KRN23 in Epidermal Nevus Syndrome (ENS)Who this might be right forEpidermal Nevus Syndrome University of Alabama at Birmingham 1
Not applicableLooking for participantsNCT06642051What this trial is testingSafety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the PeripheryWho this might be right forChronic Venous Insufficiency, CVIVenous MalformationsVenous Leg Ulcers+3 more Sonablate 30
Large-scale testing (Phase 3)Study completedNCT03581591What this trial is testingOpen Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic RicketsWho this might be right forHypophosphatemiaHypophosphatemic RicketsPain, Chronic Redwood Dermatology Sciences 1
Large-scale testing (Phase 3)Not Yet RecruitingNCT07285005What this trial is testingInvestigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES SyndromeWho this might be right forVenous MalformationsLymphatic MalformationsKlippel-Trenaunay Syndrome+1 more Kaken Pharmaceutical 150
Not applicableLooking for participantsNCT02399527What this trial is testingLymphatic Anomalies Registry for the Assessment of Outcome DataWho this might be right forLymphatic MalformationGeneralized Lymphatic Anomaly (GLA)Central Conducting Lymphatic Anomaly+7 more Boston Children's Hospital 1,000
Testing effectiveness (Phase 2)Study completedNCT02304367What this trial is testingStudy of Burosumab (KRN23) in Adults With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS)Who this might be right forTumor Induced Osteomalacia (TIO)Epidermal Nevus Syndrome (ENS) Kyowa Kirin, Inc. 17
Not applicableLooking for participantsNCT05563831What this trial is testingNational Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)Who this might be right forPIK3CA-related Overgrowth SpectrumCLOVES SyndromeKlippel Trenaunay Syndrome+6 more Institut National de la Santé Et de la Recherche Médicale, France 2,500
Testing effectiveness (Phase 2)Study completedNCT02722798What this trial is testingKRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus SyndromeWho this might be right forTumor-Induced Osteomalacia or Epidermal Nevus Syndrome Kyowa Kirin Co., Ltd. 14
Testing effectiveness (Phase 2)WithdrawnNCT05195762What this trial is testing12-week Study of NFX-179 Gel in Subjects With Epidermal NeviWho this might be right forEpidermal NeviNevus Sebaceus Albert Chiou