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Results for “Factor VIII (FVIII) Gene”

41 trials

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Showing 20 of 41 results

Not applicableLooking for participantsNCT06147414
What this trial is testing

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

Who this might be right for
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, IncludingSickle Cell DiseaseCystic Fibrosis+12 more
Assistance Publique - Hôpitaux de Paris 550
Not applicableActive Not RecruitingNCT03432520
What this trial is testing

Long-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia A

Who this might be right for
Hemophilia A
Spark Therapeutics, Inc. 29
Large-scale testing (Phase 3)Study completedNCT03370913
What this trial is testing

Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301)

Who this might be right for
Hemophilia A
BioMarin Pharmaceutical 144
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07226206
What this trial is testing

A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A

Who this might be right for
Hemophilia A
Hoffmann-La Roche 5
Testing effectiveness (Phase 2)Ended earlyNCT04541628
What this trial is testing

Safety & Efficacy of Encapsulated Allogeneic FVIII Cell Therapy in Haemophilia A

Who this might be right for
Hemophilia A
Eli Lilly and Company 3
Very early researchLooking for participantsNCT05152732
What this trial is testing

Safety and Tolerability of VGB-R04 in Patients With Haemophilia B

Who this might be right for
Hemophilia B
Institute of Hematology & Blood Diseases Hospital, China 3
Large-scale testing (Phase 3)Study completedNCT04323098
What this trial is testing

Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A

Who this might be right for
Hemophilia A
BioMarin Pharmaceutical 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT04684940
What this trial is testing

Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors

Who this might be right for
Hemophilia A With InhibitorHemophilia A With Anti Factor VIII
BioMarin Pharmaceutical 10
Not applicableLooking for participantsNCT04728841
What this trial is testing

Gene Therapy for Chinese Hemophilia A

Who this might be right for
Hemophilia AGene Therapy
Institute of Hematology & Blood Diseases Hospital, China 12
Early research (Phase 1)Active Not RecruitingNCT03818763
What this trial is testing

Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A

Who this might be right for
Hemophilia A
Medical College of Wisconsin 5
Testing effectiveness (Phase 2)Study completedNCT02576795
What this trial is testing

Gene Therapy Study in Severe Haemophilia A Patients (270-201)

Who this might be right for
Severe Haemophilia A
BioMarin Pharmaceutical 15
Testing effectiveness (Phase 2)Active Not RecruitingNCT03001830
What this trial is testing

Gene Therapy for Haemophilia A.

Who this might be right for
Hemophilia A
University College, London 14
Testing effectiveness (Phase 2)Study completedNCT03489291
What this trial is testing

Dose Confirmation Trial of AAV5-hFIXco-Padua

Who this might be right for
Hemophilia B
CSL Behring 3
Large-scale testing (Phase 3)Looking for participantsNCT05568719
What this trial is testing

Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively

Who this might be right for
Hemophilia AHemophilia B
Pfizer 173
Not applicableLooking for participantsNCT05523128
What this trial is testing

The Efficacy and Safety of ZS802 in Chinese Hemophilia A Patients.

Who this might be right for
Hemophilia A
Institute of Hematology & Blood Diseases Hospital, China 6
Testing effectiveness (Phase 2)Active Not RecruitingNCT03588299
What this trial is testing

Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle"

Who this might be right for
Hemophilia A
Bayer 11
Early research (Phase 1)Not Yet RecruitingNCT04418414
What this trial is testing

Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia A

Who this might be right for
Hemophilia A
Expression Therapeutics, LLC 7
Early research (Phase 1)UnknownNCT03217032
What this trial is testing

Lentiviral FVIII Gene Therapy

Who this might be right for
Hemophilia A
Shenzhen Geno-Immune Medical Institute 10
Testing effectiveness (Phase 2)Study completedNCT03734588
What this trial is testing

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Who this might be right for
Adeno-Associated Virus (AAV)Blood Coagulation DisorderBlood Coagulation Disorders, Inherited+14 more
Spark Therapeutics, Inc. 4
Not applicableEnrolling By InvitationNCT05768386
What this trial is testing

A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)

Who this might be right for
Hemophilia A
BioMarin Pharmaceutical 172
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