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Results for “Familial Erythrophagocytic Lymphohistiocytosis”

16 trials

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Showing 16 of 16 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT06736080
What this trial is testing

Safety and Efficacy of Gene Therapy of FHL Type 3 Caused by Mutations in the Human UNC13D Gene by Transplantation of a Single Dose of Autologous CD34+ Cells Transduced ex Vivo With the UNC13D LV Vector Expressing the UNC13D cDNA

Who this might be right for
Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL 3)
Assistance Publique - Hôpitaux de Paris 5
Not applicableEnded earlyNCT00006054
What this trial is testing

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Who this might be right for
Immunologic Deficiency SyndromesChediak-Higashi SyndromeCommon Variable Immunodeficiency+11 more
Fairview University Medical Center
Early research (Phase 1)Active Not RecruitingNCT01494103
What this trial is testing

Administration of Donor T Cells With the Caspase-9 Suicide Gene

Who this might be right for
Acute Lymphoblastic LeukemiaMyelodysplastic SyndromeAcute Myeloid Leukemia+7 more
Baylor College of Medicine 15
Not applicableUnknownNCT00006056
What this trial is testing

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders

Who this might be right for
Chediak-Higashi SyndromeGraft Versus Host DiseaseX-Linked Lymphoproliferative Syndrome+3 more
Fairview University Medical Center 40
Not applicableStudy completedNCT05687474
What this trial is testing

Baby Detect : Genomic Newborn Screening

Who this might be right for
Congenital Adrenal HyperplasiaFamilial Hyperinsulinemic Hypoglycemia 1Phosphoglucomutase 1 Deficiency+121 more
Centre Hospitalier Universitaire de Liege 6,824
Not applicableNot Yet RecruitingNCT07741747
What this trial is testing

Impact of Ultra-fast Genetic Diagnosis of Familial Lymphohistiocytosis on the Time to Bone Marrow Transplantation and Overall Survival

Who this might be right for
Familial LymphohistiocytosisLymphohistiocytosis
Assistance Publique Hopitaux De Marseille 240
Testing effectiveness (Phase 2)Study completedNCT00368355
What this trial is testing

T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts

Who this might be right for
Acute Lymphoblastic LeukemiaNon Hodgkins LymphomaMyelodysplastic Syndrome+6 more
Baylor College of Medicine 46
Early research (Phase 1)Active Not RecruitingNCT00710892
What this trial is testing

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Who this might be right for
Acute Lymphoblastic LeukemiaNon-Hodgkin's LymphomaMyelodysplastic Syndrome+1 more
Baylor College of Medicine 10
Post-approval studies (Phase 4)Study completedNCT05744063
What this trial is testing

A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Swedish Orphan Biovitrum 13
Not applicableUnknownNCT06587191
What this trial is testing

Emapalumab Efficacy in Children With Primary Hemophagocytic Lymphohistiocytosis

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 7
Large-scale testing (Phase 3)Study completedNCT03312751
What this trial is testing

Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Swedish Orphan Biovitrum 35
Testing effectiveness (Phase 2)Looking for participantsNCT05762640
What this trial is testing

Ruxolitinib as First Line Treatment in Primary Haemophagocytic Lymphohistiocytosis (R-HLH)

Who this might be right for
Haemophagocytic Lymphohistiocytosis
Assistance Publique - Hôpitaux de Paris 20
Testing effectiveness (Phase 2)UnknownNCT02061800
What this trial is testing

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Who this might be right for
Chronic Myeloid Leukemia (CML)Acute Myelogenous Leukemia (AML)Myelodysplastic Syndrome (MDS)+3 more
Diane George 14
Not applicableActive Not RecruitingNCT03827343
What this trial is testing

Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer

Who this might be right for
Macrophage Activation SyndromePrimary Hemophagocytic Lymphohistiocytosis
National Cancer Institute (NCI) 500
Testing effectiveness (Phase 2)Active Not RecruitingNCT01966367
What this trial is testing

CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation

Who this might be right for
Bone Marrow Failure SyndromeSevere Aplastic AnemiaSevere Congenital Neutropenia+13 more
Diane George 37
Large-scale testing (Phase 3)Study completedNCT01818492
What this trial is testing

Study to Investigate Safety, Efficacy of an Anti-IFNγ mAb in Children With Primary Haemophagocytic Lymphohistiocytosis

Who this might be right for
Primary Haemophagocytic Lymphohistiocytosis
Swedish Orphan Biovitrum 45