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Results for “Familial Transthyretin Cardiac Amyloidosis”

91 trials

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Showing 20 of 91 results

Early research (Phase 1)Study completedNCT04601051
What this trial is testing

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Not applicableLooking for participantsNCT05697861
What this trial is testing

Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Not applicableStudy completedNCT01432587
What this trial is testing

The Effect of Diflunisal on Familial Transthyretin Amyloidosis

Who this might be right for
Amyloidosis
Umeå University 55
Testing effectiveness (Phase 2)Study completedNCT03458130
What this trial is testing

Study of AG10 in Amyloid Cardiomyopathy

Who this might be right for
Familial ATTR-CM (ATTRm-CM, or FAC)Wild-type ATTR-CM (ATTRwt-CM)
Eidos Therapeutics, a BridgeBio company 49
Large-scale testing (Phase 3)Study completedNCT03759379
What this trial is testing

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

Who this might be right for
Amyloidosis, HereditaryTransthyretin Amyloidosis
Alnylam Pharmaceuticals 164
Not applicableLooking for participantsNCT06907186
What this trial is testing

An Interventional Pilot Study to Investigate the Feasibility and Acceptance of a Structured Psychological Support Program for Patients, Caregivers, and Presymptomatic Carriers in Hereditary Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Hereditary Transthyretin Amyloidosis
Fondazione IRCCS Policlinico San Matteo di Pavia 150
Not applicableStudy completedNCT03812172
What this trial is testing

Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations

Who this might be right for
Amyloid Cardiomyopathy, Transthyretin-Related
Mathew S. Maurer, MD 646
Post-approval studies (Phase 4)Ended earlyNCT04306510
What this trial is testing

Characterize Adverse Events Occurring Within One Day of TEGSEDI Administration to Adult Participants With hATTR-PN

Who this might be right for
Hereditary Transthyretin Amyloidosis With Polyneuropthy
Akcea Therapeutics 8
Large-scale testing (Phase 3)Active Not RecruitingNCT06128629
What this trial is testing

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Intellia Therapeutics 1,200
Not applicableLooking for participantsNCT04849754
What this trial is testing

Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy

Who this might be right for
Cardiac Amyloidosis
GCS Ramsay Santé pour l'Enseignement et la Recherche 30
Not applicableActive Not RecruitingNCT05873868
What this trial is testing

Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran

Who this might be right for
Transthyretin AmyloidosisAmyloidosis, Hereditary
Rennes University Hospital 20
Not applicableLooking for participantsNCT06907836
What this trial is testing

Description of a Retrospective Cohort of Patients With Transthyretin Cardiac Amyloidosis (ATTR-CA) in Internal Medicine

Who this might be right for
Cardiac Amyloidosis
University Hospital, Strasbourg, France 30
Large-scale testing (Phase 3)Not Yet RecruitingNCT07116473
What this trial is testing

To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Who this might be right for
Amyloidosis in Transthyretin (TTR)Amyloidosis, FamilialAmyloid Cardiomyopathy+7 more
Eidos Therapeutics, a BridgeBio company 250
Large-scale testing (Phase 3)Active Not RecruitingNCT04153149
What this trial is testing

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Alnylam Pharmaceuticals 655
Testing effectiveness (Phase 2)Looking for participantsNCT06634108
What this trial is testing

Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy

Who this might be right for
Amyloid Cardiomyopathy
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's 20
Not applicableLooking for participantsNCT05040373
What this trial is testing

Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program

Who this might be right for
Hereditary Transthyretin-mediated (hATTR) AmyloidosisPolyneuropathy
Alnylam Pharmaceuticals 10
Large-scale testing (Phase 3)Looking for participantsNCT07223203
What this trial is testing

TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

Who this might be right for
Hereditary Transthyretin-Mediated Amyloidosis With PolyneuropathyhATTR-PN
Alnylam Pharmaceuticals 125
Not applicableLooking for participantsNCT06251778
What this trial is testing

NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis

Who this might be right for
AmyloidosisAmyloidosis CardiacATTR Amyloidosis Wild Type
Paolo Milani 200
Not applicableStudy completedNCT01705626
What this trial is testing

Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)

Who this might be right for
Polyneuropathy, AmyloidNeuropathic PainCardiac Failure+2 more
CENTOGENE GmbH Rostock 500
Large-scale testing (Phase 3)Study completedNCT03862807
What this trial is testing

Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant

Who this might be right for
Amyloidosis, FamilialTransthyretin Amyloidosis
Alnylam Pharmaceuticals 24
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