Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “First-line Chemotherapy”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Early research (Phase 1)UnknownNCT03971214
What this trial is testing

PD-1 Inhibitors Consolidation in Extensive-stage Small Cell Lung Cancer

Who this might be right for
Extensive-stage Small Cell Lung CancerRadiotherapyImmunotherapy
Chinese Academy of Medical Sciences 6
Large-scale testing (Phase 3)Looking for participantsNCT05603104
What this trial is testing

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

Who this might be right for
Schizophrenia and Related DisordersMajor Depressive DisorderBipolar Depression
Dr. Inge Winter 1,254
Large-scale testing (Phase 3)Active Not RecruitingNCT03164616
What this trial is testing

Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).

Who this might be right for
Non Small Cell Lung Cancer NSCLC
AstraZeneca 1,186
Large-scale testing (Phase 3)Study completedNCT01351415
What this trial is testing

Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche 485
Large-scale testing (Phase 3)Study completedNCT01523587
What this trial is testing

LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim 795
Large-scale testing (Phase 3)Ended earlyNCT02117479
What this trial is testing

Study of Ruxolitinib in Pancreatic Cancer Patients (Janus 1)

Who this might be right for
Pancreatic Cancer
Incyte Corporation 321
Not applicableStudy completedNCT01483027
What this trial is testing

Efficacy Evaluation of TheraSphere Following Failed First Line Chemotherapy in Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
Boston Scientific Corporation 428
Large-scale testing (Phase 3)Active Not RecruitingNCT04035486
What this trial is testing

Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

Who this might be right for
Non-Small Cell Lung Cancer
AstraZeneca 587
Early research (Phase 1)Looking for participantsNCT04297605
What this trial is testing

Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2

Who this might be right for
Non-small Cell Lung Cancer
University of Rochester 60
Large-scale testing (Phase 3)Study completedNCT00861094
What this trial is testing

Radiation Therapy + Combination Chemotherapy as 1st-Line Therapy for Patients With Inoperable Esophageal Cancer

Who this might be right for
Esophageal Cancer
UNICANCER 266
Testing effectiveness (Phase 2)UnknownNCT00580359
What this trial is testing

S-1 vs Capecitabine in the Elderly and/or Poor Performance Status Patients With Recurrent or Metastatic Gastric Cancer

Who this might be right for
Stomach Neoplasms
National Cancer Center, Korea 96
Testing effectiveness (Phase 2)WithdrawnNCT01889680
What this trial is testing

Safety and Effectiveness Study of Chemotherapy and Ziv-aflibercept to Treat Metastatic Colorectal Cancer

Who this might be right for
Colorectal CancerMetastatic Colorectal Cancer
NSABP Foundation Inc
Testing effectiveness (Phase 2)Ended earlyNCT00979641
What this trial is testing

Biweekly Avastin and Docetaxel as the First Line Treatment for Patients With Metastatic Breast Cancer

Who this might be right for
Neoplasms
Tampere University Hospital 65
Testing effectiveness (Phase 2)UnknownNCT05621434
What this trial is testing

Evaluate Inetetamab + Pyrotinib + Chemotherapy in Previously Untreated HER2-Positive Metastatic Breast Cancer

Who this might be right for
HER2-positive Recurrent/Metastatic Breast Cancer
Fujian Medical University 63
Large-scale testing (Phase 3)Study completedNCT05807893
What this trial is testing

Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases

Who this might be right for
Non-small Cell Lung Cancer Stage IIBevacizumabImmunotherapy+1 more
Sun Yat-sen University 40
Testing effectiveness (Phase 2)Looking for participantsNCT07554521
What this trial is testing

Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States

Who this might be right for
Advanced Unresectable Gastric AdenocarcinomaEsophageal Squamous Cell CarcinomaAdvanced Gastroesophageal Adenocarcinoma
BeOne Medicines 30
Testing effectiveness (Phase 2)Study completedNCT03227328
What this trial is testing

CDK4/6-inhibitor or Chemotherapy, in Combination with ENDOcrine Therapy, for Advanced Breast Cancer / KENDO

Who this might be right for
Hormone Receptor Positive Breast CancerMetastatic Breast CancerHormone Receptor Negative Breast Cancer
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS 52
Not applicableStudy completedNCT07207928
What this trial is testing

Evaluation of Clinical Outcomes, Tolerability, and Costs of Avelumab Maintenance and Pembrolizumab Second-Line Therapy in Advanced Urothelial Cancer.

Who this might be right for
Urothelial Cancer
Azienda Ospedaliera Universitaria Integrata Verona 35
Testing effectiveness (Phase 2)Looking for participantsNCT07636798
What this trial is testing

Hepatic Arterial Infusion Chemotherapy Plus Envafolimab and Lenvatinib for First-Line Unresectable Advanced Biliary Tract Cancer

Who this might be right for
Biliary Tract Cancer
West China Hospital 20
Testing effectiveness (Phase 2)Study completedNCT00083928
What this trial is testing

Efficacy of Å6 in Ovarian Cancer Patients Following First-Line Chemotherapy and a Rising CA125 Levels

Who this might be right for
Ovarian CancerPrimary Peritoneal Carcinoma
Ångstrom Pharmaceuticals 60
Next Page