Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “First-line Treatment”

4,046 trials

Showing 20 of 4,046 results

Not applicableActive Not RecruitingNCT04767594
What this trial is testing

First-line Palbociclib and Endocrine Therapy for Patients With HR+/HER2- Advanced Breast Cancer in the Real-world Setting.

Who this might be right for
Breast Neoplasms
Pfizer 1,409
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07261215
What this trial is testing

Zuberitamab for EBV Infection Post-Allo-HSCT

Who this might be right for
HSCTEBV Infection
Institute of Hematology & Blood Diseases Hospital, China 20
Not applicableUnknownNCT01756625
What this trial is testing

PREMIUM, Observational Study

Who this might be right for
First Line WT KRAS mCRC
Dr.Laurent Mineur 500
Not applicableEnded earlyNCT02949908
What this trial is testing

MEasuring Satisfaction of Treatment With REbif After Initial Treatment of Multiple Sclerosis (MS)

Who this might be right for
Multiple Sclerosis
Merck KGaA, Darmstadt, Germany 2
Early research (Phase 1)Ended earlyNCT00424840
What this trial is testing

Phase I/II Study to Evaluate the Efficacy and Safety of a Combination Chemotherapy

Who this might be right for
Lung Cancer
University of Massachusetts, Worcester 12
Large-scale testing (Phase 3)UnknownNCT02633189
What this trial is testing

Study Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer

Who this might be right for
Non-squamous Non-small Cell Lung Cancer
National Cancer Institute, Naples 200
Not applicableStudy completedNCT01893268
What this trial is testing

An Observational Study of Avastin (Bevacizumab) in Elderly Patients With Non-Squamous Non-Small Cell Lung Cancer in Clinical Practice

Who this might be right for
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche 279
Testing effectiveness (Phase 2)Active Not RecruitingNCT01820910
What this trial is testing

Phase II Trial of First-line Doxycycline for Ocular Adnexal Marginal Zone Lymphoma Treatment

Who this might be right for
Marginal Zone Lymphoma of Ocular Adnexal
International Extranodal Lymphoma Study Group (IELSG) 34
Testing effectiveness (Phase 2)UnknownNCT04590625
What this trial is testing

Apatinib Combined With Abraxane and Carboplatin or Cisplatinum as First-line Treatment for Epithelial Ovarian Cancer

Who this might be right for
Ovarian Cancer
Zhongshan Hospital Xiamen University 58
Early research (Phase 1)UnknownNCT00562068
What this trial is testing

Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma

Who this might be right for
LymphomaSmall Intestine Cancer
Cancer Research UK 30
Testing effectiveness (Phase 2)UnknownNCT05329025
What this trial is testing

QL1706 Combined With Chemotherapy in Advanced Non-small Cell Lung Cancer

Who this might be right for
Non-small-cell Lung Cancer
Qilu Pharmaceutical Co., Ltd. 100
Post-approval studies (Phase 4)Not Yet RecruitingNCT06351891
What this trial is testing

Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin

Who this might be right for
Helicobacter Pylori Infection
Qilu Hospital of Shandong University 248
Not applicableStudy completedNCT03602755
What this trial is testing

The First-line Treatment of Patients With Newly Diagnosed Transplant-ineligible Multiple Myeloma in Spain

Who this might be right for
Multiple Myeloma
Celgene 706
Post-approval studies (Phase 4)Study completedNCT02088515
What this trial is testing

Nedaplatin (Jiebaishu®) Combined With Docetaxel for Advanced Lung Squamous Cell Carcinoma

Who this might be right for
Squamous Cell Carcinoma
Jiangsu Simcere Pharmaceutical Co., Ltd. 290
Testing effectiveness (Phase 2)Study completedNCT01648517
What this trial is testing

Genotype-Driven Treatment of Advanced Non-small Cell Lung Cancer Based on mRNA Expression of ERCC1 & RRM1 as First-line Chemotherapy

Who this might be right for
Non-small Cell Lung Carcinoma
Yonsei University 60
Not applicableStudy completedNCT01437618
What this trial is testing

First-line FOLFOXIRI Plus Bevacizumab in BRAF Mutant Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Azienda Ospedaliero, Universitaria Pisana 15
Testing effectiveness (Phase 2)Study completedNCT02879318
What this trial is testing

Gemcitabine and Nab-Paclitaxel vs Gemcitabine, Nab-Paclitaxel, Durvalumab and Tremelimumab as 1st Line Therapy in Metastatic Pancreatic Adenocarcinoma

Who this might be right for
Pancreatic Adenocarcinoma
Canadian Cancer Trials Group 180
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06750952
What this trial is testing

Ivonescimab Combined with Chemotherapy As First-line Treatment of Relapsed or Metastatic Thymic Cancer: a Prospective, Single Arm, Phase II Trial

Who this might be right for
Relapsed or Metastatic Thymic CancerFirst-line Treatment
Sun Yat-sen University 24
Testing effectiveness (Phase 2)Looking for participantsNCT07169552
What this trial is testing

HC010 in First-line PD-L1 Positive Advanced NSCLC Patients

Who this might be right for
NSCLC
HC Biopharma Inc. 50
Large-scale testing (Phase 3)Looking for participantsNCT05253651
What this trial is testing

Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Who this might be right for
Colorectal Neoplasms
Seagen, a wholly owned subsidiary of Pfizer 400
Load More Results

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation