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Results for “Gene Mutation-Related Cancer”

117 trials

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Showing 20 of 117 results

Testing effectiveness (Phase 2)UnknownNCT06237413
What this trial is testing

ZG2001 in Participants With KRAS Mutated Advanced Solid Tumours

Who this might be right for
Solid TumorKRAS Mutation-Related Tumors
Suzhou Zelgen Biopharmaceuticals Co.,Ltd 110
Not applicableUnknownNCT05136014
What this trial is testing

Evaluation of the Response to Tyrosine Kinase Inhibitors in Localized Non-small Cell Lung Cancer (NSCLC) Patients With EGFR Mutation in a Patient-derived Organoid Model

Who this might be right for
Lung CancerLung AdenocarcinomaEGFR Activating Mutation+2 more
Central Hospital, Nancy, France 200
Testing effectiveness (Phase 2)Ended earlyNCT02822482
What this trial is testing

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
UNICANCER 11
Not applicableUnknownNCT04825899
What this trial is testing

Gene Abnormalities and Prognosis in Diffuse Large B-cell Lymphoma

Who this might be right for
Diffuse Large B Cell Lymphoma, Gene Mutation
Fudan University 100
Testing effectiveness (Phase 2)Looking for participantsNCT07148128
What this trial is testing

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

Who this might be right for
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic AdenocarcinomaAdvanced or Metastatic KRAS-mutant Tumor in Colorectal CancerAdvanced or Metastatic KRAS-mutant Tumor in Non Small Cell Lung Cancer+2 more
Auricula Biosciences Inc.
Post-approval studies (Phase 4)Ended earlyNCT05183828
What this trial is testing

Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer

Who this might be right for
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8+2 more
University of Washington 62
Early research (Phase 1)WithdrawnNCT04602117
What this trial is testing

ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer

Who this might be right for
HER2-positive Breast CancerHER2 LowSYD-985+24 more
QuantumLeap Healthcare Collaborative
Not applicableLooking for participantsNCT01994057
What this trial is testing

A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)EGFR-TKI Resistant MutationEGFR-TKI Sensitizing Mutation+2 more
Sun Yat-sen University 1,000
Not applicableNot Yet RecruitingNCT06521684
What this trial is testing

Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

Who this might be right for
Endometrial NeoplasmsTP53 Gene MutationChromosomal Instability+1 more
Peking Union Medical College Hospital 110
Not applicableEnrolling By InvitationNCT06943313
What this trial is testing

Breast Cancer PET/CT Imaging With 68Ga-pAKTi

Who this might be right for
Breast CancersPIK3CA Mutation-Related TumorsPI3K Pathway Activated Tumors+1 more
Fudan University 20
Not applicableUnknownNCT05383014
What this trial is testing

FLT3-ITD Gene Mutation and CD135 Expression in Acute Myeloid Leukemia.

Who this might be right for
Acute Myeloid Leukemia
Assiut University 82
Testing effectiveness (Phase 2)Study completedNCT01983124
What this trial is testing

Vemurafenib + Fotemustine to Treat Advanced Melanoma Patients With V600BRAF Mutation Recurred While on Vemurafenib

Who this might be right for
Malignant Melanoma Stage IV
Paola Queirolo 31
Large-scale testing (Phase 3)Study completedNCT00186212
What this trial is testing

Alternative Support for Rural and Isolated Women in an HMO

Who this might be right for
Stress Disorders, Post-traumaticDepressionBreast Cancer
Stanford University 150
Large-scale testing (Phase 3)Study completedNCT03551626
What this trial is testing

Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes

Who this might be right for
Malignant Melanoma
Novartis Pharmaceuticals 552
Early research (Phase 1)Looking for participantsNCT06902376
What this trial is testing

XL092 and Cemiplimab in BRAF WT Thyroid Cancer

Who this might be right for
Anaplastic Thyroid CancerThyroid CancerBRAF Mutation-Related Tumors
UNC Lineberger Comprehensive Cancer Center 12
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06456138
What this trial is testing

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

Who this might be right for
KRAS Mutation-Related TumorsAdvanced Lung CancerRefractory Tumor
Shanghai Chest Hospital 60
Early research (Phase 1)Study completedNCT03792516
What this trial is testing

Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3)

Who this might be right for
Vulvar DysplasiaHPV-Related Vulvar Intraepithelial NeoplasiaPreinvasive Vulvar Disease+2 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 15
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Early research (Phase 1)Looking for participantsNCT05868226
What this trial is testing

PRE-I-SPY Phase I/Ib Oncology Platform Program

Who this might be right for
HER2-positive Breast CancerMetastatic CancerMetastatic Breast Cancer+18 more
QuantumLeap Healthcare Collaborative 124
Not applicableUnknownNCT04481152
What this trial is testing

Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx Paraganglioma

Who this might be right for
Genetic PredispositionSDH Gene MutationEnvironmental Exposure
Assistance Publique - Hôpitaux de Paris 100
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