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Results for “Gene Mutations”

2,193 trials

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Showing 20 of 2,193 results

Early research (Phase 1)UnknownNCT04448379
What this trial is testing

Efficacy and Safety of JMT101 Combined With Afatinib (or Osimertinib) in Patients With Non-Small Cell Lung Cancer

Who this might be right for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Shanghai JMT-Bio Inc. 48
Not applicableUnknownNCT05133388
What this trial is testing

The Prevelence of HBB c.93-21 G-A in β Thalassemia Patients

Who this might be right for
Beta-Thalassemia
Assiut University 150
Not applicableLooking for participantsNCT04151342
What this trial is testing

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

Who this might be right for
CancerMalignancies MultipleMalignant Solid Tumor+7 more
University Health Network, Toronto 5,500
Not applicableUnknownNCT02309866
What this trial is testing

Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases

Who this might be right for
Retinitis Pigmentosa
Hillel Yaffe Medical Center 100
Not applicableWithdrawnNCT04007562
What this trial is testing

Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency

Who this might be right for
LIPIN1 Deficiency
Assistance Publique - Hôpitaux de Paris
Not applicableUnknownNCT04909073
What this trial is testing

Observational Study of Afatinib 30 mg Daily

Who this might be right for
Non-Small Cell Lung CancerEpidermal Growth Factor Receptor Mutation
National University Hospital, Singapore 69
Testing effectiveness (Phase 2)WithdrawnNCT02355431
What this trial is testing

Itacitinib in Combination With Erlotinib in Non Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Who this might be right for
Solid Tumors and Hematologic MalignancyNSCLC (Non-small Cell Lung Carcinoma)
Incyte Corporation
Early research (Phase 1)Looking for participantsNCT06484556
What this trial is testing

T Cell Receptor Gene-Engineered T Cell Therapy Targeting KRAS Mutations in the Treatment of Subjects With Advanced Solid Tumor

Who this might be right for
Tumor, Solid
Tao Zhang 9
Not applicableStudy completedNCT02035046
What this trial is testing

Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter

Who this might be right for
Heterozygous Carriers of Gitelman Syndrome
Assistance Publique - Hôpitaux de Paris 250
Not applicableUnknownNCT03837054
What this trial is testing

Does Chemotherapy Train the Mutation of the Pig-A Gene? (PIGA)

Who this might be right for
Breast Cancer Female
Assistance Publique Hopitaux De Marseille 30
Large-scale testing (Phase 3)Ended earlyNCT02298166
What this trial is testing

Study of Crenolanib in Combination With Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia and Activating FLT3 Mutations

Who this might be right for
Acute Myeloid Leukemia
University of Ulm 9
Not applicableLooking for participantsNCT05805202
What this trial is testing

Functional Implications of Rare Gene Mutations in aHUS Open the Door to Personalized Therapy

Who this might be right for
Atypical Hemolytic Uremic Syndrome
Mario Negri Institute for Pharmacological Research 112
Large-scale testing (Phase 3)Active Not RecruitingNCT04768972
What this trial is testing

FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

Who this might be right for
Amyotrophic Lateral Sclerosis
Ionis Pharmaceuticals, Inc. 89
Testing effectiveness (Phase 2)UnknownNCT01131429
What this trial is testing

A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Who this might be right for
Neoplasms, LungCarcinoma, Non-Small Cell LungDrug Therapy+1 more
Chinese PLA General Hospital 60
Testing effectiveness (Phase 2)Study completedNCT01854294
What this trial is testing

GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)

Who this might be right for
Amyotrophic Lateral Sclerosis
Genervon Biopharmaceuticals, LLC 12
Early research (Phase 1)Active Not RecruitingNCT07038369
What this trial is testing

ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations

Who this might be right for
Advanced Solid TumorsBreast CancerBreast Carcinoma+24 more
Atavistik Bio, Inc 134
Testing effectiveness (Phase 2)Looking for participantsNCT05536505
What this trial is testing

Adjuvant Treatment Based on MRD for EGFR Mutant NSCLC

Who this might be right for
MRD
Guangdong Association of Clinical Trials 180
Testing effectiveness (Phase 2)Study completedNCT03987295
What this trial is testing

Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)

Who this might be right for
Frontotemporal Dementia
Alector Inc. 33
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07414290
What this trial is testing

A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R08b in Parkinson's Disease Patients With GBA1 Mutations

Who this might be right for
Parkinson Disease (PD)
Shanghai Vitalgen BioPharma Co., Ltd. 17
Testing effectiveness (Phase 2)UnknownNCT00299897
What this trial is testing

SP01A: The Study of an Oral Entry Inhibitor in Treatment-Experienced HIV Patients

Who this might be right for
HIV InfectionsHuman Immunodeficiency Virus
Samaritan Pharmaceuticals, Inc 60
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