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Results for “Genetic Mutations”

1,961 trials

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Showing 20 of 1,961 results

Very early researchUnknownNCT03728322
What this trial is testing

IHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

Who this might be right for
Thalassemia
Allife Medical Science and Technology Co., Ltd. 12
Testing effectiveness (Phase 2)Study completedNCT01260181
What this trial is testing

Erlotinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations

Who this might be right for
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT06303167
What this trial is testing

Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 19
Testing effectiveness (Phase 2)Study completedNCT03037385
What this trial is testing

Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors

Who this might be right for
RET-altered Non Small Cell Lung CancerMedullary Thyroid CancerRET-altered Papillary Thyroid Cancer+37 more
Hoffmann-La Roche 590
Not applicableLooking for participantsNCT05848271
What this trial is testing

Natural History Study of Patients with HPDL Mutations

Who this might be right for
Mitochondrial EncephalomyopathiesHereditary Spastic ParaplegiaSpastic Paraplegia+4 more
University of California, San Diego 50
Not applicableStudy completedNCT05264532
What this trial is testing

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Ohio State University Comprehensive Cancer Center 58
Testing effectiveness (Phase 2)Looking for participantsNCT07079475
What this trial is testing

Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8)

Who this might be right for
Non-Small Cell Lung Cancer
Dizal (Jiangsu) Pharmaceutical Co., Ltd. 200
Testing effectiveness (Phase 2)Study completedNCT00001965
What this trial is testing

Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM)

Who this might be right for
Cardiomyopathy, HypertrophicHeart Hypertrophy
National Heart, Lung, and Blood Institute (NHLBI) 32
Not applicableLooking for participantsNCT03684109
What this trial is testing

Non-invasive Glioma Characterization Through Molecular Imaging

Who this might be right for
GliomaBrain TumorPrimary Brain Tumor+2 more
University of Miami 30
Testing effectiveness (Phase 2)Study completedNCT02589236
What this trial is testing

Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Nivalis Therapeutics, Inc. 138
Not applicableWithdrawnNCT04219111
What this trial is testing

Gene Expression Profiles in CML Non-responders

Who this might be right for
Gene Expression Profiles in CML Non-responders
Sheffield Children's NHS Foundation Trust
Not applicableStudy completedNCT02876939
What this trial is testing

Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy

Who this might be right for
Atunomic Neuropathy
NYU Langone Health 16
Early research (Phase 1)Study completedNCT01877811
What this trial is testing

Study of RXDX-105, Potent RET Inhibitor in Patients With Advanced Lung Cancer and Other Solid Tumors

Who this might be right for
Solid Tumors
Hoffmann-La Roche 143
Testing effectiveness (Phase 2)Looking for participantsNCT06563999
What this trial is testing

Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.

Who this might be right for
Lung Cancer Stage IIIMutation
Sun Yat-sen University 120
Testing effectiveness (Phase 2)Study completedNCT00234663
What this trial is testing

PTC124 for Cystic Fibrosis

Who this might be right for
Cystic Fibrosis
PTC Therapeutics 24
Not applicableStudy completedNCT00579007
What this trial is testing

Decision-making Regarding Prophylactic Mastectomy and Oophorectomy in Women Seeking Genetic Counseling and Testing for BRCA1/2 Mutations

Who this might be right for
Breast CancerOvarian Cancer
Memorial Sloan Kettering Cancer Center 224
Not applicableLooking for participantsNCT02478892
What this trial is testing

Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

Who this might be right for
Pancreatic Cancer
Abramson Cancer Center at Penn Medicine 200
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Not applicableActive Not RecruitingNCT07096206
What this trial is testing

Characteristics and Impacts of X-linked Hypohidrotic Ectodermal Dysplasia (XLHED) in Boys: An Observational International Study

Who this might be right for
X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED)
Pierre Fabre Medicament 27
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439279
What this trial is testing

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 35
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