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Results for “Genomic Instability”

70 trials

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Showing 20 of 70 results

Not applicableUnknownNCT04191226
What this trial is testing

Genetic Mutation in Recurrent Cervical Cancer

Who this might be right for
Recurrent Cervical CancerNucleotide VariantCopy Number Variation+6 more
Lei Li 300
Not applicableStudy completedNCT03485196
What this trial is testing

The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation

Who this might be right for
Gastric Cancer
Affiliated Hospital of Qinghai University 1,000
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06646445
What this trial is testing

Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study.

Who this might be right for
Colon Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group 60
Early research (Phase 1)Study completedNCT03053466
What this trial is testing

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Who this might be right for
Solid TumorMicrosatellite InstabilityMismatch Repair Deficiency+1 more
Apollomics (Australia) Pty. Ltd. 30
Not applicableUnknownNCT04122092
What this trial is testing

Evaluation of Ultrasensitive Chromosomal Aneuploidy Detection for Detecting Minimal Residual Disease in Multiple Myeloma

Who this might be right for
Multiple Myeloma
Shanghai Changzheng Hospital 100
Not applicableUnknownNCT03744962
What this trial is testing

MSI in Circulatory DNA of Endometrial Cancer

Who this might be right for
Microsatellite InstabilityLynch SyndromeEndometrial Cancer+1 more
Lei Li 100
Not applicableStudy completedNCT07180966
What this trial is testing

Development and Validation of the Surgical Assessment and Healthcare (SAH) Index for Gastric Cancer Treatment Evaluation

Who this might be right for
Gastric Cancer (GC)
Ruijin Hospital 780
Early research (Phase 1)Active Not RecruitingNCT05787587
What this trial is testing

PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+6 more
IDEAYA Biosciences 216
Not applicableStudy completedNCT06414304
What this trial is testing

Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy

Who this might be right for
Colorectal CancerColorectal Cancer MetastaticMSI-H Colorectal Cancer+3 more
OncoAtlas LLC 30
Not applicableStudy completedNCT03047226
What this trial is testing

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer

Who this might be right for
Lynch Syndrome
Second Affiliated Hospital, Zhejiang University, School of Medicine 311
Testing effectiveness (Phase 2)Active Not RecruitingNCT02628067
What this trial is testing

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

Who this might be right for
Advanced CancerAnal CarcinomaAnal Cancer+22 more
Merck Sharp & Dohme LLC 1,609
Not applicableStudy completedNCT05162248
What this trial is testing

Microsatellite Instability in Colorectal Cancers

Who this might be right for
Colorectal CancerColorectal CarcinomaMicrosatellite Instability High+2 more
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 231
Testing effectiveness (Phase 2)Study completedNCT06428487
What this trial is testing

Neoadjuvant Prolgolimab Monotherapy in Locally Advanced MMR-deficient Colorectal Cancer

Who this might be right for
Colorectal Cancer
Blokhin's Russian Cancer Research Center 30
Testing effectiveness (Phase 2)Study completedNCT02314481
What this trial is testing

Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity

Who this might be right for
Non-small Cell Lung Cancer
University College, London 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
Testing effectiveness (Phase 2)Active Not RecruitingNCT03428802
What this trial is testing

Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationLocally Advanced Solid Neoplasm+17 more
Rutgers, The State University of New Jersey 21
Large-scale testing (Phase 3)Looking for participantsNCT05770102
What this trial is testing

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

Who this might be right for
MalignancyMalignant NeoplasmLymphoproliferative Disorders+7 more
Cancer Research UK 30
Post-approval studies (Phase 4)UnknownNCT03109119
What this trial is testing

Does Sevoflurane Cause Genomic Damage

Who this might be right for
Anesthesia; Adverse Effect
Jubilee Mission Medical College and Research Institute 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT04006262
What this trial is testing

Pre-operative Nivolumab and Ipilimumab, Followed by Post-operative Nivolumab, for MSI/dMMR Oeso-gastric Adenocarcinoma.

Who this might be right for
Localized Oesogastric AdenocarcimonaMSI and or dMMR
GERCOR - Multidisciplinary Oncology Cooperative Group 32
Not applicableUnknownNCT05058937
What this trial is testing

Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre

Who this might be right for
Solid TumorMetastatic Cancer
The Belgian Society of Medical Oncology 936
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