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Results for “Germline Mutation”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)UnknownNCT03553004
What this trial is testing

Niraparib in Metastatic Pancreatic Cancer After Previous Chemotherapy (NIRA-PANC): a Phase 2 Trial

Who this might be right for
Pancreatic Cancer
University of Kansas Medical Center 18
Not applicableEnded earlyNCT04668521
What this trial is testing

Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Who this might be right for
Adnexal MassGermline BRCA1 Gene MutationGermline BRCA2 Gene Mutation+1 more
Aspira Women's Health 215
Not applicableStudy completedNCT02289326
What this trial is testing

Biomarker Monitoring in TP53 Mutation Carriers

Who this might be right for
Li-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier
Scripps Health 6
Large-scale testing (Phase 3)Ended earlyNCT04729387
What this trial is testing

Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected

Who this might be right for
Ovarian Cancer
Novartis Pharmaceuticals 358
Early research (Phase 1)Study completedNCT01981525
What this trial is testing

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Who this might be right for
Li-Fraumeni Syndrome
National Cancer Institute (NCI) 26
Not applicableStudy completedNCT00342797
What this trial is testing

Retinoblastoma Biomarker Study

Who this might be right for
RetinoblastomaMelanomaSarcoma
National Cancer Institute (NCI) 2,136
Not applicableLooking for participantsNCT04903782
What this trial is testing

Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer

Who this might be right for
Neoplastic Syndromes, HereditaryCancerGenetic Predisposition to Disease
Sydney Children's Hospitals Network 270
Not applicableStudy completedNCT04206891
What this trial is testing

CDH1 Germline Mutations in Lobular Breast Cancer

Who this might be right for
Lobular Breast CarcinomaCDH1 Gene Inactivation
European Institute of Oncology 421
Large-scale testing (Phase 3)UnknownNCT04296370
What this trial is testing

Fluzoparib±Apatinib Versus Chemotherapy Treatment of Physician's Choice in HER2-negative Metastatic Breast Cancer Patients With Germline BRCA Mutation

Who this might be right for
Treatment in HER2-negative Metastatic Breast Cancer Patients With Germline BRCA Mutation
Jiangsu HengRui Medicine Co., Ltd. 474
Not applicableLooking for participantsNCT03058588
What this trial is testing

Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes

Who this might be right for
Leukemia
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 20
Not applicableStudy completedNCT00582803
What this trial is testing

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 85
Post-approval studies (Phase 4)Study completedNCT02476968
What this trial is testing

To Assess the Efficacy and Safety of Olaparib Maintenance Monotherapy in the Treatment of Ovarian Cancer

Who this might be right for
BRCA or HRR+ Mutated Ovarian Cancer Patients
AstraZeneca 181
Testing effectiveness (Phase 2)Active Not RecruitingNCT03330847
What this trial is testing

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Who this might be right for
Metastatic Triple Negative Breast Cancer
AstraZeneca 273
Not applicableLooking for participantsNCT06022016
What this trial is testing

Study of Families With an Hemopathies Predisposition Related to the DDX41 Gene.

Who this might be right for
DDX41 Gene Mutation
Institut Claudius Regaud 910
Not applicableStudy completedNCT02154672
What this trial is testing

Prostate Cancer Screening in Men With Germline BRCA2 Mutations

Who this might be right for
Prostate Cancer
Yale University 1
Not applicableLooking for participantsNCT02705846
What this trial is testing

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations

Who this might be right for
Prostate Cancer
Institute of Cancer Research, United Kingdom 4,260
Early research (Phase 1)Looking for participantsNCT06090669
What this trial is testing

Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency

Who this might be right for
Inherited Bone Marrow Failure SyndromeFamilial Platelet Disorder With Predisposition to Myeloid Malignancies
National Cancer Institute (NCI) 75
Not applicableActive Not RecruitingNCT04585074
What this trial is testing

Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery

Who this might be right for
Breast NeoplasmsGermline BRCA1 Gene MutationGermline BRCA2 Gene Mutation+2 more
Severance Hospital 2,000
Not applicableActive Not RecruitingNCT05410951
What this trial is testing

LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients

Who this might be right for
Lobular Breast CarcinomaLobular in Situ Breast CarcinomaBRCA1 Mutation+1 more
European Institute of Oncology 800
Testing effectiveness (Phase 2)UnknownNCT04556292
What this trial is testing

A Phase II Study to Assess the Efficacy and Safety of SC10914 in the Metastatic Breast Cancer Patients

Who this might be right for
Breast Cancer MetastaticBRCA 1 Gene MutationBRCA 2 Gene Mutation
Jiangxi Qingfeng Pharmaceutical Co. Ltd. 78
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