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Results for “Germline Mutation Abnormality”

89 trials

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Showing 20 of 89 results

Testing effectiveness (Phase 2)Study completedNCT01967576
What this trial is testing

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Who this might be right for
PheochromocytomaParaganglioma
National Cancer Institute (NCI) 14
Not applicableUnknownNCT04983628
What this trial is testing

Molecular Profiling in Prostate Cancer

Who this might be right for
Prostate Cancer MetastaticProstate Cancer RecurrentGermline BRCA1 Gene Mutation+2 more
Hellenic Cooperative Oncology Group 250
Not applicableLooking for participantsNCT02302742
What this trial is testing

Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

Who this might be right for
Breast CancerHereditary Breast and Ovarian Cancer
University of Kansas Medical Center 1,500
Not applicableUnknownNCT02207686
What this trial is testing

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Who this might be right for
Von Hippel-Lindaus Disease
Marie Luise Bisgaard, MD 50
Not applicableLooking for participantsNCT07019155
What this trial is testing

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

Who this might be right for
Germline MutationMyelodysplastic SyndromesAcute Myeloid Leukemia
National Cancer Institute (NCI) 510
Testing effectiveness (Phase 2)Looking for participantsNCT05485766
What this trial is testing

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

Who this might be right for
Triple Negative Breast NeoplasmsTriple Negative Breast CancerBreast Neoplasms+5 more
Okayama University 23
Testing effectiveness (Phase 2)Ended earlyNCT02326844
What this trial is testing

BMN 673 (Talazoparib), an Oral PARP Inhibitor, in People With Deleterious BRCA1/2 Mutation-Associated Ovarian Cancer Who Have Had Prior PARP Inhibitor Treatment

Who this might be right for
Ovarian Cancer
National Cancer Institute (NCI) 3
Early research (Phase 1)Ended earlyNCT04770246
What this trial is testing

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

Who this might be right for
Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsAdvanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Taiho Oncology, Inc. 17
Not applicableUnknownNCT04368442
What this trial is testing

Cohort Study of Patients With HER2-negative MBC and BRCA 1/2 Pathogenic Mutation

Who this might be right for
Breast Cancer Metastatic
Samsung Medical Center 583
Not applicableStudy completedNCT00342797
What this trial is testing

Retinoblastoma Biomarker Study

Who this might be right for
RetinoblastomaMelanomaSarcoma
National Cancer Institute (NCI) 2,136
Large-scale testing (Phase 3)Looking for participantsNCT06533384
What this trial is testing

PARPi or Capecitabine Combined With PD-1 Inhibitors as Adjuvant Therapy in High-risk TNBC

Who this might be right for
Triple-negative Breast Cancer
Guangdong Provincial People's Hospital 310
Not applicableLooking for participantsNCT05983991
What this trial is testing

Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation

Who this might be right for
GATA2 Gene Mutation
Institut Claudius Regaud 150
Not applicableStudy completedNCT05721326
What this trial is testing

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

Who this might be right for
Genetic Predisposition to DiseaseBreast Cancer FemaleOvarian Cancer+4 more
Abramson Cancer Center at Penn Medicine 1,330
Not applicableUnknownNCT03365986
What this trial is testing

Systemic Screening for Hereditary Colorectal Cancer in China

Who this might be right for
Hereditary Colorectal Cancer
Sun Yat-sen University 500
Testing effectiveness (Phase 2)Study completedNCT01540565
What this trial is testing

Veliparib in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierOvarian Epithelial Tumor+3 more
National Cancer Institute (NCI) 52
Testing effectiveness (Phase 2)Looking for participantsNCT04090567
What this trial is testing

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Study completedNCT04089189
What this trial is testing

Study of IMP4297 in Patients With BRCA1/2 Mutation Ovarian Cancer

Who this might be right for
Ovarian Cancer
Impact Therapeutics, Inc. 93
Early research (Phase 1)Looking for participantsNCT04890613
What this trial is testing

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Who this might be right for
Advanced Solid Tumor
Senhwa Biosciences, Inc. 52
Not applicableStudy completedNCT00582803
What this trial is testing

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 85
Not applicableLooking for participantsNCT05769517
What this trial is testing

PREDICTION OF GERMLINE BRCA 1/2 GENES FROM HEALTHY OVARIES

Who this might be right for
BRCA MutationOvarian CancerUltrasound Therapy; Complications
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 1,300
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