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Results for “Glioblastoma, IDH-mutant”

29 trials

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Showing 20 of 29 results

Early research (Phase 1)Looking for participantsNCT07544992
What this trial is testing

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma, IDH-Wildtype
City of Hope Medical Center 24
Early research (Phase 1)Looking for participantsNCT06815029
What this trial is testing

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma
City of Hope Medical Center 27
Testing effectiveness (Phase 2)Looking for participantsNCT07301268
What this trial is testing

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

Who this might be right for
Glioblastoma, IDH-WildtypeProgressive Astrocytoma, IDH-Mutant, Grade 4Progressive Glioblastoma+6 more
Mayo Clinic 36
Not applicableLooking for participantsNCT06623565
What this trial is testing

Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques

Who this might be right for
GlioblastomaAstrocytoma, IDH-Mutant, Grade 4
Amsterdam UMC, location VUmc 30
Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Early research (Phase 1)Enrolling By InvitationNCT06896110
What this trial is testing

Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

Who this might be right for
Glioblastoma (GBM)Diffuse Midline Glioma (DMG)Astrocytoma, IDH-Mutant, Grade 4+2 more
Andrew P. Groves 34
Early research (Phase 1)Study completedNCT04908176
What this trial is testing

A Drug-drug Interaction Study of Avapritinib and Midazolam

Who this might be right for
Gastrointestinal Stromal TumorsGISTNon-resectable Advanced Solid Tumors+1 more
Blueprint Medicines Corporation 10
Not applicableStudy completedNCT05375318
What this trial is testing

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels

Who this might be right for
Astrocytoma, Grade IVGlioblastomaGlioblastoma Multiforme+5 more
Juan M Garcia-Gomez 50
Testing effectiveness (Phase 2)Study completedNCT02968940
What this trial is testing

Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma

Who this might be right for
Glioblastoma
NYU Langone Health 6
Large-scale testing (Phase 3)Active Not RecruitingNCT06105619
What this trial is testing

PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

Who this might be right for
Glioblastoma
Beijing Pearl Biotechnology Limited Liability Company 84
Testing effectiveness (Phase 2)Active Not RecruitingNCT05565521
What this trial is testing

UNITy-BasED MR-Linac Adaptive Simultaneous Integrated Hypofractionated Boost Trial for High Grade Glioma in the Elderly

Who this might be right for
Glioblastoma Multiforme, AdultGlioblastoma, IDH-mutant
Sunnybrook Health Sciences Centre 55
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06258018
What this trial is testing

Niraparib and Temozolomide in Patients Glioblastoma

Who this might be right for
Glioma, Malignant
Armando Santoro, MD 86
Early research (Phase 1)Looking for participantsNCT05879367
What this trial is testing

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Who this might be right for
Glioblastoma, IDH-wildtypeGlioblastomaGlioblastoma Multiforme+4 more
Orbus Therapeutics, Inc. 66
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Testing effectiveness (Phase 2)Ended earlyNCT05267106
What this trial is testing

Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

Who this might be right for
GlioblastomaAdult-type Diffuse Gliomas
Incyte Corporation 83
Post-approval studies (Phase 4)Study completedNCT06625047
What this trial is testing

Comparing Telehealth and In-person Assessments in Glioma Patients Receiving Oral Chemotherapy

Who this might be right for
Astrocytoma, IDH-MutantGlioblastomaGlioma+1 more
Mayo Clinic 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT04145115
What this trial is testing

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 4Diffuse GliomaGlioblastoma, IDH-Wildtype+1 more
National Cancer Institute (NCI) 37
Not applicableNot Yet RecruitingNCT06368934
What this trial is testing

Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma

Who this might be right for
GliomaGlioblastoma
Huashan Hospital 326
Early research (Phase 1)Looking for participantsNCT07223034
What this trial is testing

177Lu-PSMA-617 in People With Gliomas

Who this might be right for
GliomaDiffuse Astrocytoma, IDH-Wildtype (Grade 2-4)Glioblastoma, IDH-wildtype+3 more
Memorial Sloan Kettering Cancer Center 20
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