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Results for “H3 K27M”

38 trials

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Showing 20 of 38 results

Early research (Phase 1)Looking for participantsNCT06305910
What this trial is testing

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics 24
Early research (Phase 1)Ended earlyNCT04771897
What this trial is testing

BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Bexion Pharmaceuticals, Inc. 10
Early research (Phase 1)Ended earlyNCT03416530
What this trial is testing

ONC201 in Pediatric H3 K27M Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGlioma, Malignant
Jazz Pharmaceuticals 134
Not applicableLooking for participantsNCT03101813
What this trial is testing

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantDiffuse Midline Glioma
Children's Hospital Medical Center, Cincinnati 1,500
Early research (Phase 1)Looking for participantsNCT05835687
What this trial is testing

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

Who this might be right for
Central Nervous System NeoplasmsAtypical Teratoid/Rhabdoid TumorDiffuse Midline Glioma, H3 K27M-Mutant+4 more
St. Jude Children's Research Hospital 48
Early research (Phase 1)Study completedNCT01922076
What this trial is testing

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligoastrocytomaDiffuse Intrinsic Pontine Glioma+3 more
National Cancer Institute (NCI) 46
Early research (Phase 1)Looking for participantsNCT05762419
What this trial is testing

FUS Etoposide for DMG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Columbia University 10
Early research (Phase 1)Looking for participantsNCT04943848
What this trial is testing

RHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Ann & Robert H Lurie Children's Hospital of Chicago 36
Not applicableLooking for participantsNCT05839379
What this trial is testing

Targeted Pediatric High-Grade Glioma Therapy

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+6 more
Nationwide Children's Hospital 350
Early research (Phase 1)Looking for participantsNCT05544526
What this trial is testing

CAR T Cells to Target GD2 for DMG

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
University College, London 12
Not applicableApproved For MarketingNCT04617002
What this trial is testing

Intermediate-size Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline Gliomas

Who this might be right for
GliomaH3 K27M
Jazz Pharmaceuticals
Testing effectiveness (Phase 2)Study completedNCT02960230
What this trial is testing

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGliomaDiffuse Midline Glioma, H3 K27M-Mutant
Sabine Mueller, MD, PhD 50
Testing effectiveness (Phase 2)Looking for participantsNCT06161974
What this trial is testing

Study of Olutasidenib and Temozolomide in HGG

Who this might be right for
High Grade GliomaAstrocytomaAstrocytoma, Grade III+16 more
Rigel Pharmaceuticals 60
Testing effectiveness (Phase 2)Looking for participantsNCT05077735
What this trial is testing

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
Mayo Clinic 29
Early research (Phase 1)Not Yet RecruitingNCT06357377
What this trial is testing

The Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

Who this might be right for
Pediatric Tumor of CNSPediatric Tumor of BrainDiffuse Midline Glioma, H3 K27M-Mutant+5 more
Neonc Technologies, Inc. 12
Early research (Phase 1)Not Yet RecruitingNCT07076498
What this trial is testing

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

Who this might be right for
Glioma
M.D. Anderson Cancer Center 20
Not applicableNot Yet RecruitingNCT06093165
What this trial is testing

RE-irradiation of Diffuse MIdline Glioma paTients

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantDiffuse Intrinsic Pontine GliomaDiffuse Glioma+3 more
Rigshospitalet, Denmark 59
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07389278
What this trial is testing

Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

Who this might be right for
GlioblastomaHigh-Grade Glioma (WHO III-IV)High-grade Glioma+2 more
Sabine Mueller, MD, PhD 97
Testing effectiveness (Phase 2)Ended earlyNCT05500508
What this trial is testing

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Who this might be right for
CancerSolid TumorSolid Carcinoma+17 more
Aminex Therapeutics, Inc. 15
Early research (Phase 1)Looking for participantsNCT04541082
What this trial is testing

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Who this might be right for
Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more
Jazz Pharmaceuticals 102
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