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Results for “H3 K28M”

39 trials

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Showing 20 of 39 results

Early research (Phase 1)Study completedNCT01922076
What this trial is testing

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligoastrocytomaDiffuse Intrinsic Pontine Glioma+3 more
National Cancer Institute (NCI) 46
Not applicableLooking for participantsNCT03101813
What this trial is testing

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantDiffuse Midline Glioma
Children's Hospital Medical Center, Cincinnati 1,500
Early research (Phase 1)Looking for participantsNCT04541082
What this trial is testing

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Who this might be right for
Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more
Jazz Pharmaceuticals 102
Testing effectiveness (Phase 2)Active Not RecruitingNCT05077735
What this trial is testing

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
Mayo Clinic 17
Testing effectiveness (Phase 2)Looking for participantsNCT05956821
What this trial is testing

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

Who this might be right for
Glioblastoma MultiformeAnaplastic AstrocytomaFibrillary Astrocytomas+5 more
University of Miami 20
Early research (Phase 1)Ended earlyNCT05478837
What this trial is testing

Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
University of California, San Francisco 4
Testing effectiveness (Phase 2)Study completedNCT02960230
What this trial is testing

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGliomaDiffuse Midline Glioma, H3 K27M-Mutant
Sabine Mueller, MD, PhD 50
Early research (Phase 1)Looking for participantsNCT06357377
What this trial is testing

The Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

Who this might be right for
Pediatric Tumor of CNSPediatric Tumor of BrainDiffuse Midline Glioma, H3 K27M-Mutant+5 more
Neonc Technologies, Inc. 12
Testing effectiveness (Phase 2)Looking for participantsNCT05009992
What this trial is testing

Combination Therapy for the Treatment of Diffuse Midline Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantRecurrent Diffuse Intrinsic Pontine Glioma+3 more
University of California, San Francisco 360
Testing effectiveness (Phase 2)Ended earlyNCT05500508
What this trial is testing

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Who this might be right for
CancerSolid TumorSolid Carcinoma+17 more
Aminex Therapeutics, Inc. 15
Early research (Phase 1)Ended earlyNCT04771897
What this trial is testing

BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Bexion Pharmaceuticals, Inc. 10
Testing effectiveness (Phase 2)Looking for participantsNCT07589257
What this trial is testing

VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantDiffuse Intrinsic Pontine Glioma
Guangzhou Virotech Pharmaceutical Co., Ltd. 10
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07389278
What this trial is testing

Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

Who this might be right for
GlioblastomaHigh-Grade Glioma (WHO III-IV)High-grade Glioma+2 more
Sabine Mueller, MD, PhD 97
Testing effectiveness (Phase 2)Active Not RecruitingNCT03581292
What this trial is testing

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Who this might be right for
Anaplastic AstrocytomaGlioblastomaMalignant Glioma
National Cancer Institute (NCI) 38
Early research (Phase 1)Looking for participantsNCT06624371
What this trial is testing

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Who this might be right for
High-grade GliomaMedulloblastomaDiffuse Intrinsic Pontine Glioma+1 more
Emory University 18
Not applicableNo Longer AvailableNCT03134131
What this trial is testing

Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline High Grade Gliomas

Who this might be right for
Glioma
Jazz Pharmaceuticals
Not applicableApproved For MarketingNCT04617002
What this trial is testing

Intermediate-size Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline Gliomas

Who this might be right for
GliomaH3 K27M
Jazz Pharmaceuticals
Early research (Phase 1)Ended earlyNCT03416530
What this trial is testing

ONC201 in Pediatric H3 K27M Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGlioma, Malignant
Jazz Pharmaceuticals 134
Not applicableNot Yet RecruitingNCT06093165
What this trial is testing

RE-irradiation of Diffuse MIdline Glioma paTients

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantDiffuse Intrinsic Pontine GliomaDiffuse Glioma+3 more
Rigshospitalet, Denmark 59
Early research (Phase 1)Looking for participantsNCT05544526
What this trial is testing

CAR T Cells to Target GD2 for DMG

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
University College, London 12
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