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Results for “H3 K28M”

39 trials

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Showing 20 of 39 results

Not applicableNo Longer AvailableNCT05518838
What this trial is testing

Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantDiffuse Intrinsic Pontine Glioma
Oblato, Inc.
Testing effectiveness (Phase 2)Study completedNCT02960230
What this trial is testing

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGliomaDiffuse Midline Glioma, H3 K27M-Mutant
Sabine Mueller, MD, PhD 50
Testing effectiveness (Phase 2)Ended earlyNCT02525692
What this trial is testing

Oral ONC201 in Adult Recurrent Glioblastoma

Who this might be right for
GlioblastomaDiffuse Midline GliomaH3 K27M Glioma+3 more
Jazz Pharmaceuticals 84
Testing effectiveness (Phase 2)Active Not RecruitingNCT03581292
What this trial is testing

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Who this might be right for
Anaplastic AstrocytomaGlioblastomaMalignant Glioma
National Cancer Institute (NCI) 38
Not applicableNo Longer AvailableNCT06439849
What this trial is testing

Single Patient Compassionate Use / Expanded Access L-S-Gboxin (Lyophilized Form of S-Gboxin) for the Treatment of Diffuse Midline Glioma

Who this might be right for
DIPG Brain TumorDiffuse Brainstem GliomaH3 K27M+2 more
Petrov, Andrey
Testing effectiveness (Phase 2)Looking for participantsNCT06161974
What this trial is testing

Study of Olutasidenib and Temozolomide in HGG

Who this might be right for
High Grade GliomaAstrocytomaAstrocytoma, Grade III+16 more
Rigel Pharmaceuticals 60
Large-scale testing (Phase 3)Looking for participantsNCT05580562
What this trial is testing

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

Who this might be right for
H3 K27MGlioma
Jazz Pharmaceuticals 510
Early research (Phase 1)Looking for participantsNCT05835687
What this trial is testing

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

Who this might be right for
Central Nervous System NeoplasmsAtypical Teratoid/Rhabdoid TumorDiffuse Midline Glioma, H3 K27M-Mutant+4 more
St. Jude Children's Research Hospital 48
Early research (Phase 1)Looking for participantsNCT04541082
What this trial is testing

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Who this might be right for
Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more
Jazz Pharmaceuticals 102
Not applicableNot Yet RecruitingNCT06093165
What this trial is testing

RE-irradiation of Diffuse MIdline Glioma paTients

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantDiffuse Intrinsic Pontine GliomaDiffuse Glioma+3 more
Rigshospitalet, Denmark 59
Early research (Phase 1)Looking for participantsNCT05544526
What this trial is testing

CAR T Cells to Target GD2 for DMG

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
University College, London 12
Early research (Phase 1)Looking for participantsNCT06305910
What this trial is testing

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics 24
Not applicableNo Longer AvailableNCT03134131
What this trial is testing

Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline High Grade Gliomas

Who this might be right for
Glioma
Jazz Pharmaceuticals
Early research (Phase 1)Looking for participantsNCT04943848
What this trial is testing

RHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Ann & Robert H Lurie Children's Hospital of Chicago 36
Early research (Phase 1)Ended earlyNCT03416530
What this trial is testing

ONC201 in Pediatric H3 K27M Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGlioma, Malignant
Jazz Pharmaceuticals 134
Not applicableLooking for participantsNCT05839379
What this trial is testing

Targeted Pediatric High-Grade Glioma Therapy

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+6 more
Nationwide Children's Hospital 350
Early research (Phase 1)Looking for participantsNCT07076498
What this trial is testing

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

Who this might be right for
Glioma
M.D. Anderson Cancer Center 20
Testing effectiveness (Phase 2)Looking for participantsNCT05843253
What this trial is testing

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+7 more
Nationwide Children's Hospital 120
Early research (Phase 1)Looking for participantsNCT04732065
What this trial is testing

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Who this might be right for
Diffuse Midline Glioma (DMG)GlioblastomaRecurrent Ependymoma+5 more
Sabine Mueller, MD, PhD 208
Testing effectiveness (Phase 2)Looking for participantsNCT05077735
What this trial is testing

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
Mayo Clinic 29
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