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Results for “HER2 Amplified”

72 trials

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Showing 20 of 72 results

Testing effectiveness (Phase 2)Looking for participantsNCT07288359
What this trial is testing

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Who this might be right for
Advanced HR+/HER2- Breast CancerAdvanced CCNE1-amplified Solid TumorsMetastatic Castration-resistant Prostate Cancer
Novartis Pharmaceuticals 205
Large-scale testing (Phase 3)Study completedNCT00005970
What this trial is testing

Doxorubicin Hydrochloride, Cyclophosphamide, and Pacltaxel With or Without Trastuzumab in Treating Women With HER2-Positive Node-Positive or High-Risk Node-Negative Breast Cancer

Who this might be right for
Breast AdenocarcinomaHER2 Positive Breast CarcinomaStage IA Breast Cancer AJCC v7+4 more
National Cancer Institute (NCI) 3,436
Not applicableStudy completedNCT00535509
What this trial is testing

Phase II Trial of Neoadjuvant[FEC100]/Cisplatin-Docetaxel ± Trastuzumab in Women With Over Expressed or Amplified Her2/Neu With Locally Advanced Breast Cancer

Who this might be right for
Breast Cancer
King Faisal Specialist Hospital & Research Center 285
Testing effectiveness (Phase 2)Active Not RecruitingNCT04482309
What this trial is testing

T-DXd in Patients With Selected HER2 Expressing Tumors

Who this might be right for
Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal CancerPart 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer
AstraZeneca 477
Testing effectiveness (Phase 2)Study completedNCT00958971
What this trial is testing

Safety and Efficacy of TKI258 in FGFR1 Amplified and Non-amplified Metastatic HER2 Negative Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Novartis Pharmaceuticals 43
Testing effectiveness (Phase 2)UnknownNCT03457896
What this trial is testing

Study of Neratinib +Trastuzumab or Neratinib + Cetuximab in Patients With KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer by HER2 Status

Who this might be right for
Metastatic Colorectal Cancer
NSABP Foundation Inc 35
Not applicableActive Not RecruitingNCT02455791
What this trial is testing

Feasibility and Identification of Breast Cancer Patients for Potential Avoidance of Surgery

Who this might be right for
Breast Cancer
M.D. Anderson Cancer Center 43
Testing effectiveness (Phase 2)Looking for participantsNCT07220135
What this trial is testing

Trial of Neoadjuvant THP vs TCHP for HER2-Amplified/Positive Breast Cancer

Who this might be right for
Breast Cancer
University of Kansas Medical Center 100
Testing effectiveness (Phase 2)Study completedNCT00721630
What this trial is testing

Novel Capecitabine Dosing Schedule in Combination With Lapatinib, Based on the Norton-Simon Mathematical Method in Patients With HER2 Overexpressed/Amplified, Trastuzumab (Herceptin) -Refractory, Metastatic Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 24
Testing effectiveness (Phase 2)Ended earlyNCT05091528
What this trial is testing

A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers

Who this might be right for
HER2-positive Breast CancerHER2-positive Gastric CancerHER2-positive Colorectal Cancer+1 more
Silverback Therapeutics 2
Testing effectiveness (Phase 2)Looking for participantsNCT06581432
What this trial is testing

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

Who this might be right for
Solid Tumours
Boehringer Ingelheim 588
Early research (Phase 1)WithdrawnNCT02205463
What this trial is testing

KD019 and Trastuzumab in Patients With Esophagus, Gastroesophageal Junction and Stomach Cancer

Who this might be right for
Esophageal CancerStomach Cancer
NYU Langone Health
Early research (Phase 1)Study completedNCT02650752
What this trial is testing

Intermittent High-Dose Lapatinib in Tandem With Capecitabine for HER2 Overexpressed/Amplified Metastatic Breast Cancer With Central Nervous System (CNS) Metastases

Who this might be right for
Metastatic Breast CancerCentral Nervous System (CNS) Metastases
Memorial Sloan Kettering Cancer Center 11
Testing effectiveness (Phase 2)WithdrawnNCT02274012
What this trial is testing

Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment

Who this might be right for
HER-2 Positive Gastric CancerGastrooesophageal CancerEsophageal Cancer
Columbia University
Testing effectiveness (Phase 2)Study completedNCT00591851
What this trial is testing

Phase II Study of Dose-Dense Doxurubicin and Cyclophosphamide (AC) Followed By Paclitaxel With Trastuzumab in HER2/ NEU-Amplified Breast Cancer: Feasibility

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 70
Testing effectiveness (Phase 2)UnknownNCT04706949
What this trial is testing

Pyrotinib Combined With Pemetrexed Plus Carboplatin in the First-line Treatment

Who this might be right for
Lung Cancer, Non-small Cell
Fudan University 26
Testing effectiveness (Phase 2)Looking for participantsNCT05800275
What this trial is testing

Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseHER2-positive Metastatic Breast Cancer
UNICANCER 30
Early research (Phase 1)Looking for participantsNCT07029399
What this trial is testing

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

Who this might be right for
HR+ Breast CancerTriple Negative Breast Cancer (TNBC)CCNE1 Amplified Advanced Solid Tumors+1 more
NiKang Therapeutics, Inc. 361
Large-scale testing (Phase 3)Study completedNCT00486954
What this trial is testing

Lapatinib in Combination With Weekly Paclitaxel in Patients With ErbB2 Amplified Advanced Gastric Cancer

Who this might be right for
Neoplasms, Gastrointestinal Tract
GlaxoSmithKline 273
Testing effectiveness (Phase 2)Ended earlyNCT05163223
What this trial is testing

Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With Breast Cancer

Who this might be right for
Breast Cancer
Aston Sci. Inc. 10
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