Not applicableLooking for participantsNCT07124000What this trial is testingDESTINY-PANTUMOUR04Who this might be right forAdenocarcinoma (NOS)Anal CancerBladder Cancer+24 more AstraZeneca 100
Testing effectiveness (Phase 2)Ended earlyNCT03784599What this trial is testingT-DM1 and Osimertinib Combination Treatment to Target HER2 Bypass Track Resistance in EGFR Mutation Positive NSCLCWho this might be right forCarcinoma, Non-Small-Cell Lung The Netherlands Cancer Institute 28
Testing effectiveness (Phase 2)Study completedNCT03845270What this trial is testingHer2-positive Lung Cancer Treated With Dedicated DrugWho this might be right forNon Small Cell Lung Cancer MetastaticNon Small Cell Lung Cancer Stage IIIHER2 Gene Mutation Intergroupe Francophone de Cancerologie Thoracique 46
Testing effectiveness (Phase 2)UnknownNCT05991518What this trial is testingIAH0968 in Combination With GC for the Treatment of HER2-Positive Unresectable Advanced/Metastatic Malignant TumorsWho this might be right forHER2 Gene Mutation SUNHO（China）BioPharmaceutical CO., Ltd. 136
Large-scale testing (Phase 3)Looking for participantsNCT06382948What this trial is testingElacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.Who this might be right forAdvanced Breast CancerER-positive Breast CancerHER2-negative Breast Cancer+1 more MedSIR 300
Testing effectiveness (Phase 2)Study completedNCT02979821What this trial is testingPoziotinib in Stage IV Lung Adenocarcinoma With HER2 Mutation (KASTT001)Who this might be right forHER2 Gene MutationAdenocarcinoma Lung Stage IV Korean Association for the Study of Targeted Therapy 6
Early research (Phase 1)UnknownNCT04764084What this trial is testingNiraparib Combined With Anlotinib in Homologous Recombination Repair (HRR) Gene-mutated Advanced Solid TumorsWho this might be right forHER2-negative Breast CancerGastric AdenocarcinomaCholangiocarcinoma+1 more Peking University Cancer Hospital & Institute 52
Testing effectiveness (Phase 2)Looking for participantsNCT07405801What this trial is testingA Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast CancerWho this might be right forBreast Cancer Hoffmann-La Roche 80
Early research (Phase 1)Looking for participantsNCT07383506What this trial is testingMutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid TumorsWho this might be right forPIK3CA MutationsAdvanced Solid Tumors, AdultEndometrial Cancer+2 more Cogent Biosciences, Inc. 90
Early research (Phase 1)Study completedNCT01104259What this trial is testingVeliparib, Cisplatin, and Vinorelbine Ditartrate in Treating Patients With Recurrent and/or Metastatic Breast CancerWho this might be right forEstrogen Receptor-negative Breast CancerHER2-negative Breast CancerHereditary Breast/Ovarian Cancer - BRCA1+6 more University of Washington 50
Early research (Phase 1)Study completedNCT06378658What this trial is testingLearn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy ParticipantsWho this might be right forAdvanced Non-small Cell Lung CancerEGFR MutationHER2 Mutation+1 more Bayer 21
Early research (Phase 1)Ended earlyNCT05511844What this trial is testingStudy of ORM-5029 in Subjects With HER2-Expressing Advanced Solid TumorsWho this might be right forHER2-positive Breast CancerHER-2 Protein OverexpressionHER-2 Gene Amplification+1 more Orum Therapeutics USA, Inc. 25
Not applicableAvailableNCT06761976What this trial is testingExpanded Access to Provide Sevabertinib (BAY 2927088) for the Treatment of Locally Advanced or Metastatic NSCLC With HER2 MutationWho this might be right forAdvanced Non-small Cell Lung CancerCancer Bayer
Testing effectiveness (Phase 2)Study completedNCT02834936What this trial is testingA Clinica Study of Pyrotinib in Patients of Advanced Non-Small Cell Lung Cancer With HER2 MutationWho this might be right forNon Small Cell Lung Jiangsu HengRui Medicine Co., Ltd. 60
Very early researchLooking for participantsNCT06824155What this trial is testingHEAT Trial (HER2 Antibody Therapy With Lutetium-177)Who this might be right forHER2 Gene MutationAdvanced Solid Tumors Radiopharm Theranostics, Ltd 30
Large-scale testing (Phase 3)Active Not RecruitingNCT04208178What this trial is testingStudy of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA MutationWho this might be right forAdvanced HER2+Breast Cancer Novartis Pharmaceuticals 19
Testing effectiveness (Phase 2)Ended earlyNCT00758134What this trial is testingTrastuzumab Therapy in Non-Small Cell Lung Cancer PatientsWho this might be right forNON-SMALL CELL LUNG CANCER Armando Santoro, MD 9
Early research (Phase 1)Active Not RecruitingNCT05650879What this trial is testingELVN-002 in HER2 Mutant Non-Small Cell Lung CancerWho this might be right forHER2 Mutant Non-small Cell Lung CancerHER2-positive Metastatic Breast CancerHER2 Gene Mutation+1 more Enliven Therapeutics 198
Testing effectiveness (Phase 2)UnknownNCT03810872What this trial is testingAn Explorative Study of Afatinib in the Treatment of Advanced Cancer Carrying an EGFR, a HER2 or a HER3 MutationWho this might be right forCancers Harbouring an EGFR Mutation, (Excluding Non-squamous Non- Small Cell Lung Cancer, a Registered Indication), a HER2 Mutation or a HER3 Mutation Universitair Ziekenhuis Brussel 87
Large-scale testing (Phase 3)Looking for participantsNCT07174336What this trial is testingTersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)Who this might be right forBreast NeoplasmsNeoplasm Metastasis Eli Lilly and Company 800