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Results for “HER2-positive Colorectal Cancer”

62 trials

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Showing 20 of 62 results

Not applicableApproved For MarketingNCT04100694
What this trial is testing

Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor

Who this might be right for
NRG1 FusionPancreatic CancerNon Small Cell Lung Cancer+8 more
Merus B.V.
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05350917
What this trial is testing

Study of Tislelizumab Combined With DisitamabVedotin and Pyrotinib Maleate in HER2-positive or Mutated Advanced Colorectal Cancer Who Failed Standard Therapy

Who this might be right for
HER2-positive or Mutated Advanced Colorectal Cancer
The First Affiliated Hospital of Zhengzhou University 20
Early research (Phase 1)Study completedNCT01576666
What this trial is testing

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Who this might be right for
Dose EscalationSafetyPreliminary Efficacy+9 more
Novartis Pharmaceuticals 120
Early research (Phase 1)UnknownNCT04660929
What this trial is testing

CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Who this might be right for
HER2-positiveAdenocarcinomaBile Duct Cancer+28 more
Carisma Therapeutics Inc 48
Testing effectiveness (Phase 2)UnknownNCT05493683
What this trial is testing

Disitamab Vedotin Combined With Tislelizumab in Advanced HER2 Positive Colorectal Cancer

Who this might be right for
Colorectal Neoplasms
The First Affiliated Hospital with Nanjing Medical University 29
Not applicableEnded earlyNCT04106167
What this trial is testing

Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy

Who this might be right for
Advanced Solid TumorLymphomaGastric Cancer+15 more
Fate Therapeutics 20
Testing effectiveness (Phase 2)UnknownNCT04227041
What this trial is testing

Pyrotinib Combined With Capecitabine for Metastatic HER-2 Positive Colorectal Cancer

Who this might be right for
HER-2 Positive Colorectal Cancer
Qingdao Zhixin Health Technology Co., Ltd. 34
Large-scale testing (Phase 3)Not Yet RecruitingNCT07384377
What this trial is testing

JSKN003 Versus Physician Choiced Treatment in Patients With HER2-positive and Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-Fu, and Irinotecan

Who this might be right for
HER2-positive Colorectal Cancer
Shanghai JMT-Bio Inc. 123
Testing effectiveness (Phase 2)Active Not RecruitingNCT04430738
What this trial is testing

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Who this might be right for
Colorectal CarcinomaGastric AdenocarcinomaGEJ Adenocarcinoma+3 more
Seagen, a wholly owned subsidiary of Pfizer 40
Testing effectiveness (Phase 2)UnknownNCT05785325
What this trial is testing

RC48-ADC Combined With Bevacizumab in HER2-positive Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07243938
What this trial is testing

Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Locally Advanced Gastric/Gastroesophageal Junction AdenocarcinomaMetastatic Colorectal Cancer (mCRC)+1 more
Tao Zhang 70
Early research (Phase 1)Study completedNCT02900664
What this trial is testing

PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)

Who this might be right for
Colorectal Cancer, Triple Negative Breast Cancer, NSCLC - Adenocarcinoma
Novartis Pharmaceuticals 283
Testing effectiveness (Phase 2)Looking for participantsNCT07589517
What this trial is testing

Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer

Who this might be right for
Colorectal CancerMetastatic Colorectal AdenocarcinomaUnresectable Colorectal Cancer
Beijing Biotech 48
Testing effectiveness (Phase 2)Looking for participantsNCT05672524
What this trial is testing

Tucatinib and Trastuzumab in People With Rectal Cancer

Who this might be right for
Adenocarcinoma of the RectumLocally Advanced Rectal AdenocarcinomaRectal Adenocarcinoma+2 more
Memorial Sloan Kettering Cancer Center 37
Large-scale testing (Phase 3)UnknownNCT05673512
What this trial is testing

To Evaluate IAH0968 in Combination With CAPEOX in HER2-positive Metastatic Colorectal Cancer

Who this might be right for
HER2 Gene Mutation
SUNHO（China）BioPharmaceutical CO., Ltd. 279
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07631871
What this trial is testing

An Exploratory Study of Zanidatamab in HER2-positive Advanced Tumor After at Least One Line of Standard Therapy

Who this might be right for
NeoplasmsSolid TumorsHER2 Positive Solid Tumor+7 more
Haihua Yuan 10
Early research (Phase 1)Active Not RecruitingNCT04704661
What this trial is testing

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Who this might be right for
Advanced Breast CarcinomaAdvanced Colon CarcinomaAdvanced Colorectal Carcinoma+37 more
National Cancer Institute (NCI) 51
Testing effectiveness (Phase 2)Looking for participantsNCT06589830
What this trial is testing

TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticAdvanced Colorectal Cancer
Suzhou Teligene Ltd. 80
Testing effectiveness (Phase 2)Ended earlyNCT04172597
What this trial is testing

Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies

Who this might be right for
Breast CancerColorectal CancerSolid Tumor+1 more
Spectrum Pharmaceuticals, Inc 1
Testing effectiveness (Phase 2)Study completedNCT03602079
What this trial is testing

Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene

Who this might be right for
HER2-positive Breast CancerHER2 Gene MutationHER-2 Gene Amplification+41 more
Klus Pharma Inc. 49
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