Early research (Phase 1)Study completedNCT03821233What this trial is testingA Dose Finding Study of ZW49 in Patients With HER2-Positive CancersWho this might be right forHER2-expressing Cancers Zymeworks BC Inc. 112
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05350917What this trial is testingStudy of Tislelizumab Combined With DisitamabVedotin and Pyrotinib Maleate in HER2-positive or Mutated Advanced Colorectal Cancer Who Failed Standard TherapyWho this might be right forHER2-positive or Mutated Advanced Colorectal Cancer The First Affiliated Hospital of Zhengzhou University 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05985707What this trial is testingKN026 Plus Chemotherapy ± KN-046 in HER2 Positive Colorectal Cancer and Biliary CarcinomaWho this might be right forHER2-positive Colorectal CancerHER2-positive Biliary Tract Cancer Peking University Cancer Hospital & Institute 80
Testing effectiveness (Phase 2)Ended earlyNCT05091528What this trial is testingA Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive CancersWho this might be right forHER2-positive Breast CancerHER2-positive Gastric CancerHER2-positive Colorectal Cancer+1 more Silverback Therapeutics 2
Testing effectiveness (Phase 2)UnknownNCT04227041What this trial is testingPyrotinib Combined With Capecitabine for Metastatic HER-2 Positive Colorectal CancerWho this might be right forHER-2 Positive Colorectal Cancer Qingdao Zhixin Health Technology Co., Ltd. 34
Testing effectiveness (Phase 2)Active Not RecruitingNCT04430738What this trial is testingTucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal CancersWho this might be right forColorectal CarcinomaGastric AdenocarcinomaGEJ Adenocarcinoma+3 more Seagen, a wholly owned subsidiary of Pfizer 40
Testing effectiveness (Phase 2)UnknownNCT05193292What this trial is testingCamrelizumab Combined With Trastuzumab and Chemotherapy in Patients With HER2-positive Advanced Colorectal CancerWho this might be right forColorectal NeoplasmsIntestinal Neoplasms Fudan University 77
Early research (Phase 1)Looking for participantsNCT06253871What this trial is testingA Phase 1/1b Study of IAM1363 in HER2 CancersWho this might be right forHER2 Mutation-Related TumorsHER2HER2-positive Breast Cancer+10 more Iambic Therapeutics, Inc 243
Testing effectiveness (Phase 2)WithdrawnNCT04464967What this trial is testingSafety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR CancersWho this might be right forAdvanced Solid TumorMetastatic CancerHER2-positive Breast Cancer+14 more NKGen Biotech, Inc.
Testing effectiveness (Phase 2)UnknownNCT03418558What this trial is testingStudy of Trastuzumab-emtansine in Patients With HER2-positive Metastatic Colorectal Cancer Progressing After Trastuzumab and Lapatinib.Who this might be right forMetastatic Colorectal Cancer Fondazione del Piemonte per l'Oncologia 13
Testing effectiveness (Phase 2)Study completedNCT01037790What this trial is testingPhase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With CancerWho this might be right forAdult Solid TumorAdenocarcinoma of the ColonAdenocarcinoma of the Rectum+36 more Abramson Cancer Center at Penn Medicine 304
Testing effectiveness (Phase 2)WithdrawnNCT05356897What this trial is testingTucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T StudyWho this might be right forMetastatic Colon AdenocarcinomaMetastatic Colorectal AdenocarcinomaMetastatic Rectal Adenocarcinoma+3 more Academic and Community Cancer Research United
Large-scale testing (Phase 3)Looking for participantsNCT05673512What this trial is testingTo Evaluate IAH0968 in Combination With CAPEOX in HER2-positive Metastatic Colorectal CancerWho this might be right forHER2 Gene Mutation SUNHO（China）BioPharmaceutical CO., Ltd. 279
Early research (Phase 1)Looking for participantsNCT03740256What this trial is testingBinary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid TumorsWho this might be right forBladder CancerHead and Neck Squamous Cell CarcinomaCancer of the Salivary Gland+7 more Baylor College of Medicine 45
Early research (Phase 1)Study completedNCT03841110What this trial is testingFT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid TumorsWho this might be right forAdvanced Solid TumorsLymphomaGastric Cancer+15 more Fate Therapeutics 37
Testing effectiveness (Phase 2)Study completedNCT02811497What this trial is testingStudy of Azacitidine and Durvalumab in Advanced Solid TumorsWho this might be right forMicrosatellite Stable Colorectal CarcinomaPlatinum Resistant Epithelial Ovarian Cancer Type IIEstrogen Receptor Positive and HER2 Negative Breast Cancer University Health Network, Toronto 28
Testing effectiveness (Phase 2)Looking for participantsNCT05672524What this trial is testingTucatinib and Trastuzumab in People With Rectal CancerWho this might be right forAdenocarcinoma of the RectumLocally Advanced Rectal AdenocarcinomaRectal Adenocarcinoma+2 more Memorial Sloan Kettering Cancer Center 37
Early research (Phase 1)Active Not RecruitingNCT06328738What this trial is testingELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast CancerWho this might be right forHER2-positive Breast CancerHER2-positive Gastric CancerHER2 Positive Solid Tumors+2 more Enliven Therapeutics 275
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06589830What this trial is testingTL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal CancerWho this might be right forColorectal Cancer MetastaticAdvanced Colorectal Cancer Suzhou Teligene Ltd. 80
Testing effectiveness (Phase 2)Looking for participantsNCT07407465What this trial is testingUpfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.Who this might be right forColorectal CancerColorectal AdenocarcinomaRectal Adenocarcinoma+4 more Gruppo Oncologico del Nord-Ovest 42