Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “HGG”

73 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 73 results

Testing effectiveness (Phase 2)Ended earlyNCT03330197
What this trial is testing

Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

Who this might be right for
Pediatric Brain TumorDiffuse Intrinsic Pontine Glioma
Alaunos Therapeutics 6
Testing effectiveness (Phase 2)Looking for participantsNCT05099003
What this trial is testing

The Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Who this might be right for
Malignant Glioma
National Cancer Institute (NCI) 132
Early research (Phase 1)Looking for participantsNCT07544992
What this trial is testing

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma, IDH-Wildtype
City of Hope Medical Center 24
Testing effectiveness (Phase 2)Active Not RecruitingNCT03581292
What this trial is testing

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

Who this might be right for
Anaplastic AstrocytomaGlioblastomaMalignant Glioma
National Cancer Institute (NCI) 38
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07439172
What this trial is testing

Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.

Who this might be right for
High Grade GliomasGlioblastomaAstrocytoma+1 more
The Cooper Health System 70
Testing effectiveness (Phase 2)Looking for participantsNCT06161974
What this trial is testing

Study of Olutasidenib and Temozolomide in HGG

Who this might be right for
High Grade GliomaAstrocytomaAstrocytoma, Grade III+16 more
Rigel Pharmaceuticals 60
Not applicableStudy completedNCT00561873
What this trial is testing

Nimotuzumab in Children With HGG

Who this might be right for
High Grade Glioma
Oncoscience AG 45
Early research (Phase 1)Looking for participantsNCT06815029
What this trial is testing

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma
City of Hope Medical Center 27
Early research (Phase 1)WithdrawnNCT02598011
What this trial is testing

The Safety of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Newly Diagnosed High Grade Glioma Receiving Standard of Care

Who this might be right for
Newly Diagnosed High Grade Glioma (HGG)
Tocagen Inc.
Testing effectiveness (Phase 2)Study completedNCT02684058
What this trial is testing

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors

Who this might be right for
Diffuse AstrocytomaAnaplastic AstrocytomaAstrocytoma+19 more
Novartis Pharmaceuticals 151
Early research (Phase 1)Looking for participantsNCT07179328
What this trial is testing

Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

Who this might be right for
GBMGlioblastoma Multiforme (GBM)Glioblastoma Multiforme of Brain+5 more
Sunnybrook Health Sciences Centre 10
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07206849
What this trial is testing

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

Who this might be right for
High Grade Glioma (HGG) of the Brain With BRAF AberrationHigh Grade Glioma (III or IV)Diffuse Intrinsic Pontine Glioma+4 more
Nationwide Children's Hospital 79
Early research (Phase 1)Looking for participantsNCT06305910
What this trial is testing

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics 24
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Testing effectiveness (Phase 2)Looking for participantsNCT05096481
What this trial is testing

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaRecurrent Medulloblastoma
Nationwide Children's Hospital 120
Early research (Phase 1)Not Yet RecruitingNCT07455045
What this trial is testing

A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)

Who this might be right for
High Grade Glioma (III or IV)Diffuse Midline Glioma (DMG)Glioblastoma (GBM)
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. 40
Very early researchLooking for participantsNCT06072586
What this trial is testing

BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions

Who this might be right for
High Grade GliomaGlioblastoma
St. Joseph's Hospital and Medical Center, Phoenix 82
Testing effectiveness (Phase 2)Study completedNCT01602588
What this trial is testing

A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)

Who this might be right for
Glioblastoma
University College, London 54
Not applicableEnded earlyNCT02039778
What this trial is testing

Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma

Who this might be right for
GlioblastomaMalignant GliomaBrain Tumors+1 more
Beth Israel Medical Center 4
Very early researchLooking for participantsNCT07210632
What this trial is testing

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

Who this might be right for
Brain CancerHGGGlioma+4 more
Eben Rosenthal 38
Load More Results